San Luis vs. Guadalajara Prediction, Odds, Liga MX Picks [2/26/2025]

Atletico San Luis will square off with Guadalajara in the Liga MX playoffs on Wednesday, starting at 10:05PM ET.

Based on updated simulation results, Dimers' advanced Liga MX model (see Dimers Pro for full access) predicts Guadalajara as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's San Luis-Guadalajara game 10,000 times," said Dave Garofolo from Dimers.

"Taking into account the most current updates and numerous additional factors, our prediction gives Atletico San Luis a 29.0% chance of winning, Guadalajara a 45.4% chance, and a 25.5% chance of a draw."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Atletico San Luis vs. Guadalajara predictions page.

READER EXCLUSIVE: Use code 20SOCCER at checkout now to get 20% off your first month of Dimers Pro! Hurry, this offer won't last long.

Get 20% off Dimers Pro With Code 20SOCCER

Get Dimers Pro

Atletico San Luis vs. Guadalajara Prediction: Who Will Win?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Wednesday's Liga MX game between Atletico San Luis and Guadalajara 10,000 times as part of our Liga MX predictions coverage.

Our famous predictive model currently suggests a 29.0% chance of Atletico San Luis winning, a 45.4% chance for Guadalajara, and a 25.5% chance of a draw.

Additionally, the over/under total of 2.5 goals also has an equal 50-50 chance of hitting, according to our model.

Pre-Game Probabilities

Last Updated: 2:05AM, Feb 27

Moneyline

Correct Score

Over / Under

Win %

Guadalajara GCH

45.4%

+100

Draw

25.5%

+290

San Luis ASL

29.0%

+280

FanDuel

BetMGM

Caesars

DraftKings

bet365

BetRivers

Get the best bets with Dimers Pro

See Matchup

Get Dimers Pro

Get the best bets with Dimers Pro

Get Dimers Pro

Atletico San Luis vs. Guadalajara Odds

We have researched the best Liga MX odds in America for this game, which are listed here:

Moneyline

Total Goals

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Atletico San Luis vs. Guadalajara Picks and Best Bets

Our model's strongest edge in today's Atletico San Luis vs. Guadalajara matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best Liga MX picks for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Unlock Every Atletico San Luis-Guadalajara Pick

Get Dimers Pro

Atletico San Luis vs. Guadalajara: Correct Score Predictions

Here are the top three most likely final scores according to our model, with a 1-1 draw being the most probable:

These predictions are based on each team's average score after 10,000 simulations, which means the most likely correct score may differ from our predicted winner.

San Luis vs. Guadalajara Game-Day Updates and Essential Details

Wednesday's game between Atletico San Luis and Guadalajara is scheduled to start at 10:05PM ET.

• Who: Atletico San Luis vs. Guadalajara
• Date: Wednesday, February 26, 2025
• Time: 10:05PM ET/7:05PM PT

Dimers.com's comprehensive preview of Wednesday's Atletico San Luis vs. Guadalajara matchup includes our prediction, picks and the latest betting odds.

Before making any Guadalajara vs. San Luis picks, be sure to check out the latest Liga MX predictions and betting advice from Dimers Pro.

Sports Betting Deals Available for Wednesday

To make the most of Wednesday's massive day of sports, headlined by basketball action across the NBA and college hoops, check out details on the latest Bet365 bonus code "DIMERS" that grants you the choice of two amazing signup promos.

Plus, find out all the details on the BetMGM bonus code "DIMERS150" which is now available in AZ, CO, DC, MA, MD, MI, NC, NJ, PA, VA, and WV. Don't miss out!

Conclusion

According to our computer model, Atletico San Luis has a 29.0% win probability on Wednesday, Guadalajara has a 45.4% win probability, and there is a 25.5% chance that the game will end in a draw.

AI and automation have enhanced this article to quickly deliver accurate Atletico San Luis vs. Guadalajara insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on Liga MX

Stay up-to-date with the latest Liga MX news, Liga MX best bets and parlay picks throughout the season.