Giants vs. Padres Prediction: San Francisco Predicted to Win Tuesday's MLB Matchup [4/29/2025]

The San Diego Padres and San Francisco Giants will lock horns in MLB action at PETCO Park on Tuesday, starting at 9:40PM ET.

The Padres will start Nick Pivetta (4-1, 1.20 ERA), while the Giants have opted for Logan Webb (3-1, 1.98 ERA).

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Giants as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's San Francisco-San Diego game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Giants with a win probability of 52%, compared to 48% for the Padres."

For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive Giants vs. Padres predictions page.

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Padres vs. Giants Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Tuesday's MLB matchup between the Giants and Padres 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Giants a 52% chance of defeating the Padres.

According to our model, the Padres (+1.5) have a 64% chance of covering the run line, while the over/under total of 6.5 runs has a 53% chance of going over.

Pre-Game Probabilities

Last Updated: 1:28AM, Apr 30

Moneyline

Over / Under

Run Line

Giants

Win %

50%

50%

-118

+105

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Padres

Giants SF

-118

Win %

50%

50%

See Matchup

Padres SD

+105

Logan Webb 3-1, 1.98 ERA

Nick Pivetta 4-1, 1.20 ERA

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Giants vs. Padres Odds [4/29/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Giants vs. Padres Picks and Best Bets

Our model's biggest edge in today's Giants vs. Padres matchup is on the over/under.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free ⚾️ Picks

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Giants vs. Padres Game-Day Updates and Essential Details

Tuesday's MLB game between the Padres and Giants at PETCO Park is scheduled to begin at 9:40PM ET.

• Who: San Francisco Giants vs. San Diego Padres
• Date: Tuesday, April 29, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's comprehensive preview of Tuesday's Giants vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any San Francisco vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Giants, with a 52% win probability, will likely beat the Padres on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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