Giants vs. Phillies Prediction: Philadelphia Predicted to Win Wednesday's MLB Matchup [4/16/2025]

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Written by Dave Garofolo

Our expert prediction for Wednesday's San Francisco Giants vs Philadelphia Phillies matchup.

San Francisco Giants-Philadelphia Phillies Predictions and Game Preview.
Citizens Bank Park sets the stage for the MLB matchup between the San Francisco Giants and Philadelphia Phillies this Wednesday.

The Philadelphia Phillies will square off with the San Francisco Giants in MLB action at Citizens Bank Park on Wednesday, commencing at 6:45PM ET.

The Phillies will send Aaron Nola (0-3, 5.51 ERA) to the mound, up against Robbie Ray (3-0, 2.94 ERA) for the Giants.

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Phillies as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's San Francisco-Philadelphia game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Phillies' chance of winning at 57%, with the Giants at 43%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Giants vs. Phillies predictions page.

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Giants vs. Giants Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB game between the Giants and Phillies 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Phillies a 57% chance of beating the Giants.

According to our model, the Giants (+1.5) have a 62% chance of covering the run line, while the 8-run over/under has a 51% chance of staying under.

Pre-Game Probabilities
Last Updated: 10:28PM, Apr 16
Moneyline
Over / Under
Run Line
Giants
Win %
43%
57%
Get the best bets with Dimers Pro
See Matchup
Phillies
Giants SF
Win %
43%
57%
See Matchup
Phillies PHI
Robbie Ray 3-0, 2.94 ERA
Aaron Nola 0-3, 5.51 ERA
Get the best bets with Dimers Pro

Giants vs. Phillies Odds [4/16/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type Giants Phillies
Run Line +1.5 (-162) -1.5 (+154)
Moneyline +130 -145
Total o8 (-110) u8 (-105)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Giants vs. Phillies Picks and Best Bets

Our model's biggest edge in today's Giants vs. Phillies matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Giants vs. Phillies Game-Day Updates and Essential Details

Wednesday's MLB matchup between the Phillies and Giants at Citizens Bank Park is scheduled to begin at 6:45PM ET.

Dimers.com's full preview of Wednesday's Giants vs. Phillies matchup includes our prediction, picks and the latest betting odds.

Before making any San Francisco vs. Philadelphia picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

Conclusion

We predict the Phillies, with a 57% win probability, will likely beat the Giants on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Phillies insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest predictions for the World Series, American League, National League and each division.

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Written by
Dave Garofolo
Content Producer

Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.

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