Giants vs. Astros Prediction: Houston Predicted to Win Wednesday's MLB Matchup [4/2/2025]

The Houston Astros and San Francisco Giants will lock horns in MLB action at Daikin Park on Wednesday, starting at 4:10PM ET.

Framber Valdez (1-0, 0.00 ERA) will start on the mound for the Astros, pitting him against Landen Roupp (0-0, 0.00 ERA) for the Giants.

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's San Francisco-Houston game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Astros' chance of winning at 60%, with the Giants at 40%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Giants vs. Astros predictions page.

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Giants vs. Giants Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Wednesday's MLB matchup between the Giants and Astros 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Astros a 60% chance of beating the Giants.

According to our model, the Giants (+1.5) have a 59% chance of covering the run line, while the 7.5-run over/under has a 52% chance of going over.

Pre-Game Probabilities

Last Updated: 8:27PM, Apr 2

Moneyline

Over / Under

Run Line

Giants

Win %

41%

59%

+145

-166

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Astros

Giants SF

+145

Win %

41%

59%

See Matchup

Astros HOU

-166

Landen Roupp 0-0, 0.00 ERA

Framber Valdez 1-0, 0.00 ERA

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Giants vs. Astros Odds [4/2/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Giants vs. Astros Picks and Best Bets

Our model's strongest edge in today's Giants vs. Astros matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Giants vs. Astros Game-Day Updates and Essential Details

Wednesday's MLB action between the Astros and Giants at Daikin Park is scheduled to commence at 4:10PM ET.

• Who: San Francisco Giants vs. Houston Astros
• Date: Wednesday, April 2, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: Daikin Park

Dimers.com's full preview of Wednesday's Giants vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any San Francisco vs. Houston picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Astros, with a 60% win probability, will likely beat the Giants on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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