Giants vs. Reds Prediction: Cincinnati Predicted to Win MLB Opening Day Matchup [3/27/2025]

The Cincinnati Reds will take on the San Francisco Giants on Opening Day of the 2022 MLB season at Great American Ball Park on Thursday, starting at 4:10PM ET.

Hunter Greene (0-0, 0.00 ERA) will be the starting pitcher for the Reds, while the Giants will counter with Logan Webb (0-0, 0.00 ERA).

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Reds as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's San Francisco-Cincinnati game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Reds with a win probability of 52% and the Giants with 48%."

For a closer look at Thursday's matchup, including best bets and picks, visit our interactive Giants vs. Reds predictions page.

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Giants vs. Giants Prediction: Who Will Win on MLB Opening Day?

Using powerful machine learning and data, we have simulated the result of Thursday's MLB game between the Giants and Reds 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Reds a 52% chance of beating the Giants.

According to our model, the over/under total of 7.5 runs has a 53% chance of going over.

Pre-Game Probabilities

Last Updated: 8:28PM, Mar 27

Moneyline

Over / Under

Run Line

Giants

Win %

48%

52%

-105

-105

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Reds

Giants SF

-105

Win %

48%

52%

See Matchup

Reds CIN

-105

Logan Webb 0-0, 0.00 ERA

Hunter Greene 0-0, 0.00 ERA

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Giants vs. Reds Odds [3/27/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Giants vs. Reds Picks and Best Bets

Our model's strongest edge in today's Giants vs. Reds matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Giants vs. Reds Game-Day Updates and Essential Details

Thursday's MLB game between the Reds and Giants at Great American Ball Park is scheduled to begin at 4:10PM ET.

• Who: San Francisco Giants vs. Cincinnati Reds
• Date: Thursday, March 27, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: Great American Ball Park

Dimers.com's in-depth preview of Thursday's Giants vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any San Francisco vs. Cincinnati picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Reds, with a 52% win probability, will likely beat the Giants on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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