- More Betting
49ers vs. Rams Prediction: San Francisco Predicted to Win Following Latest Data Analysis for NFL Week 3 [2024]
The Los Angeles Rams and San Francisco 49ers will lock horns in Week 3 of the NFL season at SoFi Stadium on Sunday, starting at 4:25PM ET.
Based on updated simulations, Dimers' advanced NFL model (see Dimers Pro for full access) projects the 49ers as the most likely winner of today's game.
"Using the most recent data, our experts ran 10,000 simulations of Sunday's 49ers-Rams game," said Dimers' Chief Content Officer, Nick Slade.
"After accounting for recent updates and other variables, our prediction shows the 49ers with a win probability of 69%, while the Rams have 31%."
49ers vs. Rams Game-Day Updates and Essential Details
The NFL Week 3 action between the Rams and 49ers at SoFi Stadium is scheduled to begin at 4:25PM ET.
- Who: San Francisco 49ers vs. Los Angeles Rams
- Date: Sunday, September 22, 2024
- Time: 4:25PM ET/1:25PM PT
- Venue: SoFi Stadium
- Tickets: Get tickets for the game on Ticketmaster
- Merchandise: Buy Rams and 49ers gear at Fanatics
- Live Stream: Watch this game on FOX via Hulu or FuboTV
Dimers.com's in-depth preview of this week's 49ers vs. Rams matchup includes our prediction, picks and the latest betting odds.
Before making any Rams vs. 49ers picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.
READER EXCLUSIVE: Sign up with code 20FOOTBALL at checkout right now to receive 20% off your first month of Dimers Pro! This offer won't last forever.
49ers vs. Rams Predictions
Using trusted machine learning and data, we have simulated the outcome of Sunday's NFL game between the 49ers and Rams 10,000 times as part of our NFL predictions coverage.
Our famous predictive model gives the 49ers a 69% chance of beating the Rams in Week 3 of the NFL season. Our predicted final score has the 49ers winning 25-19.
According to our model, the Rams (+6.5) have a 55% chance of covering the spread, while the 44.5-point over/under has an equal 50-50 chance of hitting.
As well as the above 49ers vs. Rams predictions, we also have the following locked and loaded for today's action:
49ers vs. Rams Odds
We have researched the best betting odds in America for this game, which are listed here:
| Bet Type | 49ers | Rams |
|---|---|---|
| Spread | -6.5 (-102) | +6.5 (-120) |
| Moneyline | -258 | +230 |
| Total | o44.5 (-110) | u44.5 (-106) |
All odds are correct at the time of publication and are subject to change.
49ers vs. Rams Picks
Our model's biggest edge in today's 49ers vs. Rams matchup is on the total.
Our expert predictions, aligned with the current odds, reveal the best NFL picks for every game throughout the season.
Full access to our picks, including this one, is available via Dimers Pro.
49ers vs. Rams TD Scorers
Who will score the first touchdown in 49ers vs. Rams?
According to our model, San Francisco's Jordan Mason is most likely to score the first TD in 49ers vs. Rams.
Our projections give Mason a 17.6% chance of scoring the first TD at SoFi Stadium, while the 49ers RB is a 62.2% chance of registering an anytime touchdown.
First Touchdown Scorer Predictions
San Francisco 49ers
| Player | First TD Probability |
|---|---|
| Jordan Mason | 17.6% |
| Brandon Aiyuk | 11.7% |
| Jauan Jennings | 6.8% |
Los Angeles Rams
| Player | First TD Probability |
|---|---|
| Kyren Williams | 12.2% |
| Demarcus Robinson | 7.7% |
| Jordan Whittington | 5.5% |
Anytime Touchdown Scorer Predictions
San Francisco 49ers
| Player | Anytime TD Probability |
|---|---|
| Jordan Mason | 62.2% |
| Brandon Aiyuk | 45.6% |
| Jauan Jennings | 31.2% |
Los Angeles Rams
| Player | Anytime TD Probability |
|---|---|
| Kyren Williams | 48.9% |
| Demarcus Robinson | 32.7% |
| Jordan Whittington | 24.2% |
For a complete analysis of the most likely first and anytime TD scorers this week, see our NFL Week 3 touchdown scorer predictions
49ers vs Rams Player Props
Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the 49ers and Rams. For detailed projections, join Dimers Pro.
Already a Dimers Pro member? Head to our 49ers-Rams page now to access every player prop projection.
49ers vs. Rams Quarterbacks
Of the starting quarterbacks, the 49ers' Brock Purdy is projected to throw for more yards than the Rams' Matthew Stafford.
49ers Rushing
Jordan Mason, Brock Purdy and Isaac Guerendo are projected to be the leading rushers for the 49ers.
| Player | Position |
|---|---|
| Jordan Mason | RB |
| Brock Purdy | QB |
| Isaac Guerendo | RB |
Rams Rushing
Kyren Williams, Blake Corum and Ronnie Rivers are expected to lead the Rams in rushing yards.
| Player | Position |
|---|---|
| Kyren Williams | RB |
| Blake Corum | RB |
| Ronnie Rivers | RB |
49ers Receiving
Brandon Aiyuk, Jauan Jennings, Eric Saubert, Chris Conley and Jacob Cowing are projected to top the receiving yards for the 49ers.
| Player | Position |
|---|---|
| Brandon Aiyuk | WR |
| Jauan Jennings | WR |
| Eric Saubert | TE |
| Chris Conley | WR |
| Jacob Cowing | WR |
Rams Receiving
Demarcus Robinson, Tyler Johnson, Colby Parkinson, Jordan Whittington and Tutu Atwell are projected to lead the Rams in receiving yards.
| Player | Position |
|---|---|
| Demarcus Robinson | WR |
| Tyler Johnson | WR |
| Colby Parkinson | TE |
| Jordan Whittington | WR |
| Tutu Atwell | WR |
NFL Fantasy and Betting Promos
Make the most of Dimers' 49ers vs. Rams predictions by exploring the two exciting offers below.
DraftKings Pick6
Sign up for DraftKings Pick6 today! Play $5 and get $50 in Pick6 Credits, plus one month of NFL RedZone access.
FanDuel Sportsbook
Get ready for NFL Week 3 by joining FanDuel Sportsbook! Bet $5 and get $200 in bonus bets, plus 3 weeks of NFL Sunday Ticket.
Conclusion
We predict the 49ers, with a 69% win probability, will likely beat the Rams in Week 3 of the NFL season.
AI and automation have enhanced this article to quickly deliver accurate 49ers vs. Rams insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.
More on NFL
Keep up with the latest NFL betting news and our data-led NFL best bets and NFL parlay picks throughout the season. Plus, our Super Bowl odds provide the latest projections for the Super Bowl, AFC, NFC and each division.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS and NFL, delivers game previews, best bets and props. He has contributed insightful articles at Dimers since 2020 as Head of Social and Community.
22,000+ 
70,000+ 
10,000,000+ 
