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49ers vs. Bills Prediction: Buffalo Predicted to Win SNF Week 13 [2024]
Our expert prediction for Sunday's San Francisco 49ers vs Buffalo Bills matchup.
The Buffalo Bills and San Francisco 49ers will lock horns in Week 13 of the NFL season at Highmark Stadium on Sunday, starting at 8:20PM ET.
Based on the latest simulation results, Dimers' proven NFL model (see Dimers Pro for full access) predicts the Bills as the most likely winner of today's game.
"Using the most recent data, our experts ran 10,000 simulations of Sunday's San Francisco-Buffalo game," said Dimers' Chief Content Officer, Nick Slade.
"After accounting for recent updates and other variables, our prediction shows the Bills with a win probability of 74%, while the 49ers have 26%."
This updated 49ers vs. Bills betting preview builds on my early 49ers vs. Bills prediction that I released at the start of the week.
For a closer look at today’s game, including the predicted score, best bets and player prop picks, visit our interactive 49ers vs. Bills predictions page.
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49ers vs. Bills Game-Day Updates and Essential Details
The NFL Week 13 matchup between the Bills and 49ers at Highmark Stadium is scheduled to begin at 8:20PM ET.
- Who: San Francisco 49ers vs. Buffalo Bills
- Date: Sunday, December 1, 2024
- Time: 8:20PM ET/5:20PM PT
- Venue: Highmark Stadium
- Tickets: Get tickets for the game on Ticketmaster
- Merchandise: Buy Bills and 49ers gear at Fanatics
Dimers.com's in-depth preview of Sunday's 49ers vs. Bills matchup includes our prediction, picks and the latest betting odds.
Before making any San Francisco vs. Buffalo picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.
49ers vs. Bills Predictions
Using innovative machine learning and data analysis, we have simulated the result of Sunday's NFL matchup between the 49ers and Bills 10,000 times as part of our NFL predictions coverage.
Our independent predictive model currently gives the Bills a 74% chance of beating the 49ers in Week 13 of the NFL season. Our predicted final score has the Bills winning 26-19.
According to our model, the bookmakers have got it right, and the 49ers and Bills each have a 50% chance of covering the spread, while the 45.5-point over/under has a 51% chance of staying under.
Along with our 49ers vs. Bills predictions, we've also here's what else we've got for today’s action:
49ers vs. Bills Odds
We have researched the best betting odds in America for this game, which are listed here:
| Bet Type | 49ers | Bills |
|---|---|---|
| Spread | +6.5 (+100) | -6.5 (-105) |
| Moneyline | +275 | -295 |
| Total | o45.5 (-110) | u45.5 (-110) |
All odds are correct at the time of publication and are subject to change.
49ers vs. Bills Picks
Our model's biggest edge in today's 49ers vs. Bills matchup is on the total.
Our expert predictions, aligned with the latest odds, reveal the best NFL picks for every game throughout the season.
Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.
49ers vs. Bills TD Scorers
Who will score the first touchdown in 49ers vs. Bills?
According to our model, San Francisco's Christian McCaffrey is most likely to score the first touchdown in 49ers vs. Bills.
Our projections give McCaffrey a 12.5% chance of getting in for six first at Highmark Stadium, while the 49ers RB is a 50.4% chance of reaching the end zone at any point in the game.
First Touchdown Scorer Predictions
San Francisco 49ers
| Player | First TD Probability |
|---|---|
| Christian McCaffrey | 12.5% |
| Deebo Samuel | 7.1% |
| George Kittle | 6.5% |
Buffalo Bills
| Player | First TD Probability |
|---|---|
| Josh Allen | 11.0% |
| James Cook | 10.6% |
| Amari Cooper | 7.2% |
Anytime Touchdown Scorer Predictions
San Francisco 49ers
| Player | Anytime TD Probability |
|---|---|
| Christian McCaffrey | 50.4% |
| Deebo Samuel | 32.0% |
| George Kittle | 29.2% |
Buffalo Bills
| Player | Anytime TD Probability |
|---|---|
| Josh Allen | 45.6% |
| James Cook | 43.8% |
| Amari Cooper | 31.0% |
For a complete analysis of the most likely first and anytime TD scorers this week, see our NFL Week 13 touchdown scorer predictions
49ers vs Bills Player Props
Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the 49ers and Bills. For detailed projections, join Dimers Pro.
Already a Dimers Pro member? Head to our 49ers-Bills page now to access every player prop projection.
49ers vs. Bills Quarterbacks
Of the starting quarterbacks, the 49ers' Brock Purdy is projected to throw for more yards than the Bills' Josh Allen.
49ers Rushing
Christian McCaffrey, Brock Purdy and Deebo Samuel are projected to be the leading rushers for the 49ers.
| Player | Position |
|---|---|
| Christian McCaffrey | RB |
| Brock Purdy | QB |
| Deebo Samuel | WR |
Bills Rushing
James Cook, Josh Allen and Ray Davis are expected to lead the Bills in rushing yards.
| Player | Position |
|---|---|
| James Cook | RB |
| Josh Allen | QB |
| Ray Davis | RB |
49ers Receiving
George Kittle, Jauan Jennings, Deebo Samuel, Christian McCaffrey and Ricky Pearsall are projected to top the receiving yards for the 49ers.
| Player | Position |
|---|---|
| George Kittle | TE |
| Jauan Jennings | WR |
| Deebo Samuel | WR |
| Christian McCaffrey | RB |
| Ricky Pearsall | WR |
Bills Receiving
Khalil Shakir, Amari Cooper, Dawson Knox, Mack Hollins and Curtis Samuel are projected to lead the Bills in receiving yards.
| Player | Position |
|---|---|
| Khalil Shakir | WR |
| Amari Cooper | WR |
| Dawson Knox | TE |
| Mack Hollins | WR |
| Curtis Samuel | WR |
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Conclusion
We predict the Bills, with a 74% win probability, will likely beat the 49ers in Week 13 of the NFL season.
AI and automation have enhanced this article to quickly deliver accurate 49ers vs. Bills insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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