San Francisco 49ers vs. Buffalo Bills Early Predictions for NFL Week 13: Odds, Picks and Preview [2024]

The Buffalo Bills and San Francisco 49ers are scheduled to meet in Week 13 of the NFL season at Highmark Stadium on Sunday, December 1, 2024, starting at 8:20PM ET.

Early simulations from Dimers' trusted NFL model favor the 49ers as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive 49ers vs. Bills predictions page.

49ers vs. Bills Week 13 Details

The NFL Week 13 game between the Bills and 49ers at Highmark Stadium is scheduled for December 1, 2024.

• Who: San Francisco 49ers vs. Buffalo Bills
• Date: Sunday, December 1, 2024
• Time: 8:20PM ET/5:20PM PT
• Venue: Highmark Stadium

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49ers vs. Bills Opening Odds

We've researched the best betting odds across America for this Week 13 game, which are listed here:

• Spread: 49ers -2 (-110), Bills +2 (-110)
• Moneyline: 49ers -125, Bills +105
• Total: Over/Under 47 (-110/-110)

San Francisco vs. Buffalo Early Predictions

Leveraging trusted machine learning and analysis, we have simulated the 49ers vs. Bills game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight Up Win Probabilities: 49ers 57%, Bills 43%
• Predicted Final Score: 49ers 23-22 Bills
• Spread: 49ers (-2) 50%, Bills (+2) 50%
• Total Points (47): Over 46%, Under 54%

As of November 24, 2024, these 49ers-Bills predictions reflect the latest data and insights available.

Conclusion

We predict the 49ers, with a 57% win probability, will likely beat the Bills in Week 13 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the 49ers vs. Bills game, with human oversight maintaining high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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