San Francisco 49ers vs. Arizona Cardinals Prediction, Odds, Picks for NFL Week 15 [2023]

The Arizona Cardinals will face the favored San Francisco 49ers in NFL Week 15 action at State Farm Stadium on Sunday, beginning at 4:05PM ET.

Dimers' comprehensive betting preview for this week's 49ers vs. Cardinals game includes the latest betting odds, as well as our predictions and picks for the game.

49ers vs. Cardinals Prediction: Who Will Win, Cover the Spread

Based on high-tech machine learning and data, Dimers.com has simulated the outcome of Sunday's 49ers-Cardinals NFL game 10,000 times as part of our NFL predictions for this week.

Dimers' renowned predictive analytics model currently gives the 49ers an 86% chance of beating the Cardinals in Week 15 of the NFL season, with our predicted final score seeing the 49ers winning 29-17.

According to our model, the Cardinals (+13.5) have a 52% chance of covering the spread, while the Over/Under total of 48 points has a 55% chance of going Under.

Today's San Francisco vs. Arizona betting preview is presented by Bet365, which has a tasty Bet $5, Get $150 in Bonus Bets offer for new users.

49ers vs. Cardinals Odds

We have sourced the best betting odds in America for this game, which are listed here:

Bet Type	49ers	Cardinals
Spread	-13.5 (-110)	+13.5 (-105)
Moneyline	-1000	+660
Total	o48 (-110)	u48 (-110)

• The Cardinals are listed as +13.5 underdogs versus the 49ers, with -105 at FanDuel Sportsbook the best odds currently available.
• For the favored 49ers (-13.5) to cover the spread, BetMGM Sportsbook has the best odds currently on offer at -110.
• FanDuel currently has the best moneyline odds for the Cardinals at +660. That means you can bet $100 to profit $660, earning a total payout of $760, if they win.
• On the other hand, BetMGM currently has the best moneyline odds for the 49ers at -1000, where you can risk $1,000 to win $100, for a total payout of $1,100, if they come out on top.
• The Over/Under for total points scored sits at 48 with DraftKings Sportsbook, which currently has the best odds for the Over at -110, as well as the best odds for the Under at -110.

Odds are correct at the time of publication and subject to change.

As always, make sure you check the sportsbooks you have access to in your state for the best NFL odds and lines.

49ers vs. Cardinals Picks

By comparing our predictions to the odds listed above, we have determined the best betting picks for this game:

Bet Type	Our Pick	Best Odds
Spread	Cardinals +13.5	-105
Moneyline	Cardinals	+660
Total	Under 48	-110

While the 49ers are more likely to win the game, according to DimersBOT, taking the Cardinals moneyline is the best option due to the edge identified when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges published here at Dimers is pivotal to achieving long-term profitability.

Dimers' NFL best bets are based on world-class simulations and wagering expertise to serve you the best possible plays every time.

49ers vs. Cardinals TD Scorers

Who will score an anytime touchdown in 49ers vs. Cardinals? The data is in.

Listed below are the most likely first touchdown and most likely anytime touchdown scorers for both the 49ers and Cardinals this Sunday.

And you know what, we provide this information to you for FREE to help you choose the best prop bets for Sunday's game.

According to DimersBOT, San Francisco's Christian McCaffrey is most likely to score the first TD in 49ers vs. Cardinals.

DimersBOT gives McCaffrey a 22.8% chance of scoring the first TD at State Farm Stadium, while the 49ers RB is a 76.5% chance of reaching the end zone at any point during the game.

Scroll down for our full list of first and anytime TD scorer probabilities.

First Touchdown Scorer Predictions

San Francisco 49ers

Player	First Touchdown Probability
Christian McCaffrey	22.8%
Brandon Aiyuk	10.7%
Deebo Samuel	9.9%
George Kittle	9.1%
Jordan Mason	4.7%

Arizona Cardinals

Player	First Touchdown Probability
James Conner	7.6%
Trey McBride	5.9%
Kyler Murray	5.5%
Marquise Brown	4.2%
Michael Wilson	3.4%

Anytime Touchdown Scorer Predictions

San Francisco 49ers

Player	Anytime Touchdown Probability
Christian McCaffrey	76.5%
Brandon Aiyuk	45.5%
Deebo Samuel	42.6%
George Kittle	39.5%
Jordan Mason	22.8%

Arizona Cardinals

Player	Anytime Touchdown Probability
James Conner	36.2%
Trey McBride	28.7%
Kyler Murray	28.0%
Marquise Brown	21.8%
Michael Wilson	17.3%

49ers vs Cardinals Player Props

Here, you will find detailed projections for all of the key offensive players from the 49ers and Cardinals, including passing, rushing and receiving yards.

49ers vs. Cardinals Quarterbacks

Of the starting quarterbacks, the 49ers' Brock Purdy is projected to have a big game with 276 passing yards. The Cardinals' Kyler Murray is expected to throw for just 188 yards.

Player	Proj. Pass Yards
Brock Purdy (SF)	276 yds
Kyler Murray (ARI)	188 yds

49ers Rushing

Player	Proj. Rush Yards
Christian McCaffrey	91 yds
Jordan Mason	25 yds
Deebo Samuel	13 yds

Cardinals Rushing

Player	Proj. Rush Yards
James Conner	74 yds
Kyler Murray	39 yds
Michael Carter	13 yds

49ers Receiving

Player	Proj. Rec. Yards
Brandon Aiyuk	72 yds
Deebo Samuel	55 yds
George Kittle	51 yds
Christian McCaffrey	34 yds
Jauan Jennings	19 yds

Cardinals Receiving

Player	Proj. Rec. Yards
Trey McBride	54 yds
Marquise Brown	46 yds
Michael Wilson	40 yds
Rondale Moore	24 yds
Greg Dortch	21 yds

Remember, our model updates regularly, so refresh this article for any changes to our betting insights before 49ers vs. Cardinals on Sunday December 17, 2023.

49ers vs. Cardinals Game Information

The NFL Week 15 game between the Cardinals and 49ers at State Farm Stadium is scheduled to start at 4:05PM ET.

• Who: San Francisco 49ers vs. Arizona Cardinals
• Date: Sunday December 17, 2023
• Time: 4:05PM ET / 1:05PM PT
• Venue: State Farm Stadium

Click or tap on See Matchup for full betting coverage of 49ers vs. Cardinals, including pregame predictions, betting picks, and live scores.

How to Bet on 49ers vs. Cardinals

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Conclusion

This preview article has been partially generated using automated processes and AI technology. Our goal is to provide timely and accurate updates on the 49ers vs. Cardinals Week 14 game, and automation assists in data collection, analysis, and formatting. Human editing and quality control is performed to ensure the content meets our editorial guidelines.

Dimers' picks and predictions are made after 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods. While our 49ers vs. Cardinals picks can help you make informed decisions, it's crucial that you only bet what you can afford to lose and manage your finances effectively.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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