49ers vs. Cardinals Prediction: Arizona Predicted to Win in NFL Week 18 [2025]

The Arizona Cardinals will square off with the San Francisco 49ers in NFL Week 18 action at State Farm Stadium on Sunday, commencing at 4:25PM ET.

Based on updated simulation results, Dimers' advanced NFL model (see Dimers Pro for full access) projects the Cardinals as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's San Francisco-Arizona game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Cardinals with a win probability of 67%, while the 49ers have 33%."

This updated 49ers vs. Cardinals betting preview builds on my early 49ers vs. Cardinals prediction that I published at the start of the week.

For expanded analysis of today’s game, including the predicted score, best bets and player prop picks, visit our interactive 49ers vs. Cardinals predictions page.

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49ers vs. Cardinals Game-Day Updates and Essential Details

The NFL Week 18 game between the Cardinals and 49ers at State Farm Stadium is scheduled to begin at 4:25PM ET.

• Who: San Francisco 49ers vs. Arizona Cardinals
• Date: Sunday, January 5, 2025
• Time: 4:25PM ET/1:25PM PT
• Venue: State Farm Stadium
• Tickets: Get tickets for the game on Ticketmaster
• Merchandise: Buy Cardinals and 49ers gear at Fanatics

Dimers.com's comprehensive preview of Sunday's 49ers vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any San Francisco vs. Arizona picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

49ers vs. Cardinals Predictions

Using innovative machine learning and data, we have simulated the outcome of Sunday's NFL game between the 49ers and Cardinals 10,000 times as part of our NFL predictions coverage.

Our independent predictive model gives the Cardinals a 67% chance of beating the 49ers in Week 18 of the NFL season. Our predicted final score has the Cardinals winning 23-19.

According to our model, the bookies have got it right, and the 49ers and Cardinals each have a 50% chance of covering the spread, while the 42.5-point over/under also has an equal 50-50 chance of hitting.

49ers vs. Cardinals Odds

We have sourced the best betting odds in America for this game, which are listed here:

Bet Type	49ers	Cardinals
Spread	+4.5 (-106)	-4.5 (-110)
Moneyline	+190	-192
Total	o42.5 (-105)	u42.5 (-110)

All odds are correct at the time of publication and are subject to change.

49ers vs. Cardinals Picks

Our model's strongest edge in today's 49ers vs. Cardinals matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best NFL picks for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

49ers vs. Cardinals TD Scorers

Who will score the first touchdown in 49ers vs. Cardinals?

According to our model, Arizona's Michael Carter is most likely to score the first TD in 49ers vs. Cardinals.

Our projections give Carter a 12.0% chance of scoring the first TD at State Farm Stadium, while the Cardinals RB is a 45.8% chance of scoring an anytime touchdown.

First Touchdown Scorer Predictions

San Francisco 49ers

Player	First TD Probability
Isaac Guerendo	11.6%
Jauan Jennings	9.2%
George Kittle	8.7%

Arizona Cardinals

Player	First TD Probability
Michael Carter	12.0%
Trey McBride	10.5%
Kyler Murray	9.8%

Anytime Touchdown Scorer Predictions

San Francisco 49ers

Player	Anytime TD Probability
Isaac Guerendo	45.9%
George Kittle	37.5%
Jauan Jennings	37.1%

Arizona Cardinals

Player	Anytime TD Probability
Michael Carter	45.8%
Trey McBride	42.1%
Kyler Murray	39.7%

49ers vs Cardinals Player Props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the 49ers and Cardinals. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our 49ers-Cardinals page now to access every player prop projection.

49ers vs. Cardinals Quarterbacks

Of the starting quarterbacks, the 49ers' Joshua Dobbs is projected to throw for fewer yards than the Cardinals' Kyler Murray.

49ers Rushing

Isaac Guerendo, Joshua Dobbs and Patrick Taylor are projected to be the leading rushers for the 49ers.

Player	Position
Isaac Guerendo	RB
Joshua Dobbs	QB
Patrick Taylor	RB

Cardinals Rushing

Michael Carter, Kyler Murray and DeeJay Dallas are expected to lead the Cardinals in rushing yards.

Player	Position
Michael Carter	RB
Kyler Murray	QB
DeeJay Dallas	RB

49ers Receiving

Jauan Jennings, George Kittle, Ricky Pearsall, Isaac Guerendo and Kyle Juszczyk are projected to top the receiving yards for the 49ers.

Player	Position
Jauan Jennings	WR
George Kittle	TE
Ricky Pearsall	WR
Isaac Guerendo	RB
Kyle Juszczyk	WR

Cardinals Receiving

Trey McBride, Marvin Harrison, Michael Wilson, Michael Carter and Elijah Higgins are projected to lead the Cardinals in receiving yards.

Player	Position
Trey McBride	TE
Marvin Harrison	WR
Michael Wilson	WR
Michael Carter	RB
Elijah Higgins	TE

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Conclusion

We predict the Cardinals, with a 67% win probability, will likely beat the 49ers in Week 18 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate 49ers vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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