San Francisco 49ers vs. Arizona Cardinals Early Predictions for NFL Week 18: Odds, Picks and Preview [2025]

The Arizona Cardinals and San Francisco 49ers will lock horns in Week 18 of the NFL season at State Farm Stadium on Sunday, January 5, 2025, with kickoff set for 4:25PM ET.

Early simulations from Dimers' trusted NFL model favor the Cardinals as the most likely winner of this game.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive 49ers vs. Cardinals predictions page.

49ers vs. Cardinals Week 18 Details

The NFL Week 18 action between the Cardinals and 49ers at State Farm Stadium is scheduled for January 5, 2025.

• Who: San Francisco 49ers vs. Arizona Cardinals
• Date: Sunday, January 5, 2025
• Time: 4:25PM ET/1:25PM PT
• Venue: State Farm Stadium

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49ers vs. Cardinals Latest Odds

We've researched the best betting odds in America for this Week 18 game, detailed below:

• Spread: 49ers +4.5 (-110), Cardinals -4.5 (-110)
• Moneyline: 49ers +180, Cardinals -198
• Total: Over/Under 42.5 (-110/-110)

San Francisco vs. Arizona Early Predictions

Leveraging trusted machine learning and analysis, we have simulated the 49ers vs. Cardinals game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight Up Win Probabilities: 49ers 34%, Cardinals 66%
• Predicted Final Score: 49ers 19-23 Cardinals
• Spread: 49ers (+4.5) 52%, Cardinals (-4.5) 48%
• Total Points (42.5): Over 50%, Under 50%

As of January 2, 2025, these 49ers-Cardinals predictions reflect the latest data and insights available.

Anytime Touchdown Scorer Predictions

Here are our initial touchdown probabilities for the 49ers-Cardinals game:

San Francisco 49ers

• Isaac Guerendo: 36.5% probability
• George Kittle: 34.1% probability
• Deebo Samuel: 32.1% probability

Arizona Cardinals

• Michael Carter: 46.1% probability
• Kyler Murray: 39.6% probability
• Trey McBride: 39.6% probability

49ers vs Cardinals Player Props

Isaac Guerendo is projected to lead rushing for the 49ers, while Michael Carter is expected to pace the Cardinals on the ground.

In the receiving game, our projections favor San Francisco's George Kittle and Arizona's Trey McBride as the likely leaders for each team.

Conclusion

We predict the Cardinals, with a 66% win probability, will likely beat the 49ers in Week 18 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the 49ers vs. Cardinals matchup, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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