Padres vs. Astros Prediction: Houston Predicted to Win Sunday's MLB Matchup [4/20/2025]

The Houston Astros and San Diego Padres will meet in MLB action at Daikin Park on Sunday, starting at 7:10PM ET.

The Astros will have Framber Valdez (1-2, 4.91 ERA) as their starting pitcher, up against Dylan Cease (1-1, 6.64 ERA) for the Padres.

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's San Diego-Houston game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Astros with a win probability of 55%, while the Padres have 45%."

For further insights into Sunday's matchup, including best bets and picks, visit our interactive Padres vs. Astros predictions page.

Get 20% off Dimers Pro With Code 20BASEBALL

Get Dimers Pro

Padres vs. Padres Prediction: Who Will Win?

Using trusted machine learning and data, we have simulated the result of Sunday's MLB matchup between the Padres and Astros 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Astros a 55% chance of defeating the Padres.

According to our model, the 7.5-run over/under also has an equal 50-50 chance of hitting.

Pre-Game Probabilities

Last Updated: 11:27PM, Apr 20

Moneyline

Over / Under

Run Line

Padres

Win %

44%

56%

+105

-118

Get the best bets with Dimers Pro

See Matchup

Get Dimers Pro

Astros

Padres SD

+105

Win %

44%

56%

See Matchup

Astros HOU

-118

Dylan Cease 1-1, 6.64 ERA

Framber Valdez 1-2, 4.91 ERA

Get the best bets with Dimers Pro

Get Dimers Pro

Padres vs. Astros Odds [4/20/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Padres vs. Astros Picks and Best Bets

Our model's strongest edge in today's Padres vs. Astros matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Unlock Every Padres-Astros Pick

Get Dimers Pro

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Padres vs. Astros Game-Day Updates and Essential Details

Sunday's MLB game between the Astros and Padres at Daikin Park is scheduled to start at 7:10PM ET.

• Who: San Diego Padres vs. Houston Astros
• Date: Sunday, April 20, 2025
• Time: 7:10PM ET/4:10PM PT
• Venue: Daikin Park

Dimers.com's in-depth preview of Sunday's Padres vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any San Diego vs. Houston picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Astros, with a 55% win probability, will likely beat the Padres on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most accurate projections for the World Series, American League, National League and each division.