Padres vs. Astros Prediction: Houston Predicted to Win Friday's MLB Matchup [4/18/2025]

MLB action continues on Friday at 8:10PM ET as the San Diego Padres take on the Houston Astros at Daikin Park.

The Astros will start Ryan Gusto (1-1, 3.00 ERA), pitting him against Kyle Hart (2-0, 5.40 ERA) for the Padres.

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's San Diego-Houston game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Astros' chance of winning is 58%, while the Padres' is 42%."

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Padres vs. Astros predictions page.

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Padres vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data analysis, we have simulated the result of Friday's MLB matchup between the Padres and Astros 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Astros a 58% chance of beating the Padres.

According to our model, the Padres (+1.5) have a 61% chance of covering the run line, while the 9-run over/under has an equal 50-50 chance of hitting.

Pre-Game Probabilities

Last Updated: 12:28AM, Apr 19

Moneyline

Over / Under

Run Line

Padres

Win %

43%

57%

+150

-155

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Astros

Padres SD

+150

Win %

43%

57%

See Matchup

Astros HOU

-155

Kyle Hart 2-0, 5.40 ERA

Ryan Gusto 1-1, 3.00 ERA

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Padres vs. Astros Odds [4/18/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Padres vs. Astros Picks and Best Bets

Our model's biggest edge in today's Padres vs. Astros matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Padres vs. Astros Game-Day Updates and Essential Details

Friday's MLB game between the Astros and Padres at Daikin Park is scheduled to commence at 8:10PM ET.

• Who: San Diego Padres vs. Houston Astros
• Date: Friday, April 18, 2025
• Time: 8:10PM ET/5:10PM PT
• Venue: Daikin Park

Dimers.com's in-depth preview of Friday's Padres vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any San Diego vs. Houston picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Astros, with a 58% win probability, will likely beat the Padres on Friday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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