Padres vs. Tigers Prediction: Detroit Predicted to Win Wednesday's MLB Matchup [4/23/2025]

The Detroit Tigers will square off with the San Diego Padres in MLB action at Comerica Park on Wednesday, commencing at 1:10PM ET.

The Tigers will have Reese Olson (2-1, 4.50 ERA) as their starting pitcher, up against Kyle Hart (2-1, 6.48 ERA) for the Padres.

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Tigers as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's San Diego-Detroit game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Tigers' chance of winning at 57%, with the Padres at 43%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Padres vs. Tigers predictions page.

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Tigers vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the outcome of Wednesday's MLB matchup between the Padres and Tigers 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Tigers a 57% chance of defeating the Padres.

According to our model, the Padres (+1.5) have a 60% chance of covering the run line, while the over/under total of 8 runs has a 54% chance of going over.

Pre-Game Probabilities

Last Updated: 5:28PM, Apr 23

Moneyline

Over / Under

Run Line

Padres

Win %

43%

57%

+145

-162

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Tigers

Padres SD

+145

Win %

43%

57%

See Matchup

Tigers DET

-162

Kyle Hart 2-1, 6.48 ERA

Reese Olson 2-1, 4.50 ERA

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Padres vs. Tigers Odds [4/23/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Padres vs. Tigers Picks and Best Bets

Our model's biggest edge in today's Padres vs. Tigers matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Video

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Padres vs. Tigers Game-Day Updates and Essential Details

Wednesday's MLB matchup between the Tigers and Padres at Comerica Park is scheduled to start at 1:10PM ET.

• Who: San Diego Padres vs. Detroit Tigers
• Date: Wednesday, April 23, 2025
• Time: 1:10PM ET/10:10AM PT
• Venue: Comerica Park

Dimers.com's in-depth preview of Wednesday's Padres vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any San Diego vs. Detroit picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Tigers, with a 57% win probability, will likely beat the Padres on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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