Padres vs. Tigers Prediction: Close Contest Projected After New Data Released for Tuesday's MLB Matchup [4/22/2025]

MLB action continues on Tuesday at 6:40PM ET as the San Diego Padres take on the Detroit Tigers at Comerica Park.

The Tigers will have Jack Flaherty (1-1, 2.53 ERA) as their starting pitcher, while the Padres will counter with Nick Pivetta (3-1, 1.56 ERA).

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts an equal chance for both the Tigers and Padres to win today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's San Diego-Detroit game," said Dimers' Chief Content Officer, Nick Slade.

"Based on the latest updates and extensive data, we predict a 50-50 chance for both the Tigers and Padres, making it a highly competitive matchup."

For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive Padres vs. Tigers predictions page.

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Tigers vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the result of Tuesday's MLB matchup between the Padres and Tigers 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently can't split the two teams, giving both the Padres and Tigers a 50% chance of winning the game.

According to our model, the Padres (+1.5) have a 69% chance of covering the run line, while the over/under total of 7 runs has a 54% chance of going over.

Pre-Game Probabilities

Last Updated: 10:32PM, Apr 22

Moneyline

Over / Under

Run Line

Padres

Win %

50%

50%

+120

-130

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See Matchup

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Tigers

Padres SD

+120

Win %

50%

50%

See Matchup

Tigers DET

-130

Nick Pivetta 3-1, 1.57 ERA

Jack Flaherty 1-1, 2.53 ERA

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Padres vs. Tigers Odds [4/22/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Padres vs. Tigers Picks and Best Bets

Our model's strongest edge in today's Padres vs. Tigers matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Padres vs. Tigers Game-Day Updates and Essential Details

Tuesday's MLB action between the Tigers and Padres at Comerica Park is scheduled to commence at 6:40PM ET.

• Who: San Diego Padres vs. Detroit Tigers
• Date: Tuesday, April 22, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Comerica Park

Dimers.com's in-depth preview of Tuesday's Padres vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any San Diego vs. Detroit picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict a close game between the Padres and Tigers on Tuesday, with each team having a 50% chance of winning.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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