Padres vs. Cubs Prediction: Cubs Predicted to Win Saturday's MLB Matchup [4/5/2025]

The Chicago Cubs will face the San Diego Padres, in what is expected to be a tight MLB game, at Wrigley Field on Saturday, commencing at 2:20PM ET.

Matthew Boyd (0-0, 0.00 ERA) will be on the bump for the Cubs, pitting him against Nick Pivetta (1-0, 0.00 ERA) for the Padres.

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Cubs as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's San Diego-CHI Cubs game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Cubs are more likely to win, while the Padres have a lower chance of victory."

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Padres vs. Cubs predictions page.

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Padres vs. Padres Prediction: Who Will Win?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Saturday's MLB game between the Padres and Cubs 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cubs a 51% chance of defeating the Padres.

According to our model, the over/under total of 6.5 runs has a 55% chance of going over.

Pre-Game Probabilities

Last Updated: 6:28PM, Apr 5

Moneyline

Over / Under

Run Line

Padres

Win %

49%

51%

+100

-115

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Cubs

Padres SD

+100

Win %

49%

51%

See Matchup

Cubs CHC

-115

Nick Pivetta 1-0, 0.00 ERA

Matthew Boyd 0-0, 0.00 ERA

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Padres vs. Cubs Odds [4/5/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Padres vs. Cubs Picks and Best Bets

Our model's biggest edge in today's Padres vs. Cubs matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Padres vs. Cubs Game-Day Updates and Essential Details

Saturday's MLB action between the Cubs and Padres at Wrigley Field is scheduled to start at 2:20PM ET.

• Who: San Diego Padres vs. Chicago Cubs
• Date: Saturday, April 5, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's comprehensive preview of Saturday's Padres vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any San Diego vs. CHI Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Cubs, with a 51% win probability, will likely beat the Padres on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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