Padres vs. Cubs Prediction: Cubs Predicted to Win Friday's MLB Matchup [4/4/2025]

The Chicago Cubs and San Diego Padres will lock horns in MLB action at Wrigley Field on Friday, starting at 2:20PM ET.

Shota Imanaga (1-0, 0.82 ERA) will get the ball for the Cubs, while the Padres have opted for Randy Vásquez (0-0, 0.00 ERA).

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's San Diego-CHI Cubs game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Cubs' chance of winning is 59%, while the Padres' is 41%."

For further insights into Friday's matchup, including best bets and picks, visit our interactive Padres vs. Cubs predictions page.

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Padres vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Friday's MLB matchup between the Padres and Cubs 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Cubs a 59% chance of defeating the Padres.

According to our model, the Padres (+1.5) have a 62% chance of covering the run line, while the 7-run over/under has a 54% chance of going over.

Padres vs. Cubs Odds [4/4/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Cubs
Run Line	+1.5 (-162)	-1.5 (+140)
Moneyline	+142	-165
Total	o7 (-105)	u7 (-112)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Cubs Picks and Best Bets

Our model's strongest edge in today's Padres vs. Cubs matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Padres vs. Cubs Game-Day Updates and Essential Details

Friday's MLB action between the Cubs and Padres at Wrigley Field is scheduled to start at 2:20PM ET.

• Who: San Diego Padres vs. Chicago Cubs
• Date: Friday, April 4, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's in-depth preview of Friday's Padres vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any San Diego vs. CHI Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 59% win probability, will likely beat the Padres on Friday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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