Reds vs. Guardians Prediction and Odds - May 17, 2022

The Cleveland Guardians take on the Cincinnati Reds at Progressive Field on Tuesday, starting at 6:10PM ET.

Zach Plesac (1-3, 4.68 ERA) will get the ball for the Guardians, up against Connor Overton (1-0, 1.59 ERA) for the Reds.

Dimers' best betting picks for Reds vs. Guardians, as well as game predictions and best odds, are detailed in this article.

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Who will win Reds vs. Guardians?

Based on state-of-the-art machine learning and data, Dimers.com has simulated Tuesday's Reds-Guardians MLB matchup 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, currently gives the Guardians a 58% chance of getting the W against the Reds .

More: Reds vs. Guardians Simulated 10,000 Times

Reds vs. Guardians Odds

• Run Line: Guardians -1.5 (+135), Reds +1.5 (-145)
• Moneyline: Guardians -155, Reds +145
• Total: Over/Under 8 (-115/+100)

Run Line, Moneyline and Over/Under

The Guardians are -1.5 favorites versus the Reds, with +135 at DraftKings Sportsbook the best odds currently available.

For the underdog Reds (+1.5) to cover the run line, Caesars Sportsbook has the best odds currently on offer at -145.

DraftKings Sportsbook currently has the best moneyline odds for the Guardians at -155, which means you can risk $155 to win $100, for a total payout of $255, if they get the W.

Elsewhere, Caesars Sportsbook currently has the best moneyline odds for the Reds at +145, where you can bet $100 to profit $145, earning a total payout of $245, if they win.

The Over/Under for total runs scored sits at 8 with DraftKings Sportsbook, which currently has the best odds for the Over at -115, while Caesars Sportsbook currently has the best odds for the Under at +100.

As always, make sure you check all the online sportsbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Reds (+1.5) are a 61% chance of covering the run line, while the 8-run Over/Under is a 55% chance of going Over.

More: Best Prop Bets to Make Today

Best Bets for Reds vs. Guardians

• Run Line: Reds +1.5 @ -145 via Caesars Sportsbook (61% probability)
• Moneyline: Reds @ +145 via Caesars Sportsbook (0.8% edge)
• Total: Over 8 @ -115 via DraftKings Sportsbook (55% probability)

Dimers' best bets are based on complex simulations and wagering intelligence to serve you the best possible plays 24/7/365.

While the Guardians are more likely to win the game, according to DimersBOT, betting on the Reds moneyline is the best option due to the edge identified when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges seen on Dimers.com is pivotal to achieving long-term profitability as a sports bettor.

Reds vs. Guardians Betting Guide

Use our interactive widget below to view the latest Moneyline, Over/Under and Run Line probabilities and odds for Cincinnati vs. Cleveland, and click or tap on See Matchup for more.

Dimers has full coverage of Tuesday's Reds-Guardians matchup, including pregame predictions, computer picks, and live win probabilities.

Remember, DimersBOT updates regularly, so keep checking this article for any changes to our betting insights before Reds vs. Guardians on Tuesday May 17, 2022.

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Reds vs. Guardians 2022 Game Info

Tuesday's matchup between the Guardians and Reds at Progressive Field is scheduled to commence at 6:10PM ET.

• Date: Tuesday May 17, 2022
• Time: 6:10PM ET / 3:10PM PT
• Venue: Progressive Field

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What MLB games are on today?

Now you've got the 411 on Reds vs. Guardians, take a look at the latest betting predictions for all upcoming MLB games in our MLB Bet Hub, where you can find probabilities and odds, and our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Lastly, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds available.