Rays vs. Guardians Prediction and Odds - Sep 27, 2022

The Cleveland Guardians face the Tampa Bay Rays in MLB action at Progressive Field on Tuesday, beginning at 6:10PM ET.

The Guardians will send Shane Bieber (12-8, 2.81 ERA) to the mound, while the Rays will counter with Corey Kluber (10-9, 4.30 ERA).

Dimers' top betting picks for Rays vs. Guardians, as well as game predictions and best odds, are featured below.

Who will win Rays vs. Guardians?

Based on trusted computer power and data, Dimers.com has simulated Tuesday's Rays-Guardians MLB game 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, currently gives the Guardians a 59% chance of winning against the Rays.

More: Rays vs. Guardians Simulated 10K Times

Rays vs. Guardians Odds

• Run Line: Guardians -1.5 (+158), Rays +1.5 (-165)
• Moneyline: Guardians -150, Rays +135
• Total: Over/Under 6.5 (-110/-105)

Run Line, Moneyline and Over/Under

The Guardians are currently -1.5 favorites against the Rays, with +158 at Caesars Sportsbook the best odds currently available.

For the underdog Rays (+1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on offer at -165.

BetMGM currently has the best moneyline odds for the Guardians at -150. That means you can risk $150 to win $100, for a total payout of $250, if they get the W.

Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for the Rays at +135, where you can bet $100 to profit $135, earning a total payout of $235, if they win.

The Over/Under sits at 6.5 with FanDuel Sportsbook, which currently has the best odds for the Over at -110, while BetMGM currently has the best odds for the Under at -105.

As always, make sure you check the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Rays (+1.5) are a 60% chance of covering the run line, while the 6.5-run Over/Under is a 59% chance of going Over.

More: Track Your Bets via Bet Center

Best Bets for Rays vs. Guardians

• Run Line: Guardians -1.5 @ +158 via Caesars Sportsbook (0.9% edge)
• Moneyline: Guardians @ -150 via BetMGM (59% probability)
• Total: Over 6.5 @ -110 via FanDuel Sportsbook (59% probability) 🔥

Every time you see a 🔥, you know you've found one of our best free picks today across any sport.

Dimers' best bets are based on world-class modeling and gambling expertise to serve you the best possible plays every day of the year.

Even though the Rays are more likely to cover the run line, our best bet of Guardians -1.5 is based on the chance of that happening, according to DimersBOT, and the top odds available.

Rays vs. Guardians Betting Guide

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Dimers has full betting coverage of Tuesday's Rays-Guardians matchup, including pregame predictions, top betting picks, and live win probabilities.

Remember, DimersBOT updates often, so keep checking this page for any changes to our betting insights ahead of Rays vs. Guardians on Tuesday September 27, 2022.

Rays vs. Guardians 2022 Game Info

Tuesday's matchup between the Guardians and Rays at Progressive Field is scheduled to commence at 6:10PM ET.

• Who: Tampa Bay Rays vs. Cleveland Guardians
• Date: Tuesday September 27, 2022
• Time: 6:10PM ET / 3:10PM PT
• Venue: Progressive Field

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