Rams vs. 49ers Week 4 Prediction and Odds - Oct 3, 2022

The San Francisco 49ers face the Los Angeles Rams in NFL Week 4 action at Levi's Stadium on Monday, beginning at 8:15PM ET.

Dimers' top betting picks for Rams vs. 49ers, plus game predictions, betting odds and projected player stats, are detailed in this article.

Today's LA Rams vs. San Francisco betting analysis is sponsored by FanDuel Sportsbook, which is currently offering a tasty No Sweat First Bet bonus for new users.

Who will win Rams vs. 49ers?

Using state-of-the-art machine learning and data, Dimers.com has simulated Monday's Rams-49ers NFL game 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, currently gives the 49ers a 57% chance of beating the Rams in Week 4 of the NFL season.

More: Rams vs. 49ers Simulated 10K Times

Rams vs. 49ers Game Odds

• Spread: 49ers -1.5 (-107), Rams +1.5 (-107)
• Moneyline: 49ers -118, Rams +110
• Total: Over/Under 42 (-110/-105)

Point Spread, Moneyline and Over/Under

The 49ers are currently -1.5 favorites versus the Rams, with -107 at PointsBet the best odds currently available.

For the underdog Rams (+1.5) to cover the spread, PointsBet also has the best odds currently on the market at -107.

FanDuel Sportsbook currently has the best moneyline odds for the 49ers at -118, which means you can risk $118 to win $100, for a total payout of $218, if they get the W.

Elsewhere, Caesars Sportsbook currently has the best moneyline odds for the Rams at +110, where you can bet $100 to profit $110, earning a total payout of $210, if they win.

The Over/Under for total points scored sits at 42 with Caesars Sportsbook, which currently has the best odds for the Over at -110, while PointsBet currently has the best odds for the Under at -105.

As always, make sure you check the sportsbooks you have access to in your state for the best NFL odds and lines.

According to DimersBOT, the 49ers (-1.5) are a 52% chance of covering the spread, while the 42-point Over/Under is considered an equal 50-50 chance of hitting.

More: Track Your Bets via Bet Center

Best Bets for Rams vs. 49ers

• Spread: 49ers -1.5 @ -107 via PointsBet (52% probability)
• Moneyline: 49ers @ -118 via FanDuel Sportsbook (57% probability)
• Total: Under 42 @ -105 via PointsBet (50% probability)

Our best bets are based on detailed modeling and gambling expertise to serve you the best possible plays every time.

Rams vs. 49ers Prediction

Dimers.com's predicted final score for LA Rams vs. San Francisco at Levi's Stadium in Week 4 has the 49ers prevailing 21-20.

Click or tap on See Matchup for more.

Dimers has full coverage of this week's Rams-49ers matchup in Week 4, including pregame predictions, best betting picks, and live win probabilities.

Rams vs. 49ers Player Props

Who will score an anytime touchdown in Rams vs. 49ers? The latest data is in.

Featured below are the most likely first touchdown and most likely anytime touchdown scorers for both the Rams and 49ers, as well as player stat projections.

And you know what, we provide this information to you for FREE to help you discover the best prop bets for Monday's game.

According to DimersBOT, Los Angeles' Cooper Kupp is most likely to score the first touchdown in Rams vs. 49ers.

DimersBOT gives Kupp a 13.2% chance of scoring the first TD at Levi's Stadium, while the Rams WR is a 50.2% chance of registering an anytime touchdown.

Scroll down for the full list of first and anytime TD scorer probabilities.

First Touchdown Scorer Probabilities

Los Angeles Rams

• Cooper Kupp: 13.2% probability
• Cam Akers: 7.9% probability
• Tyler Higbee: 7.5% probability
• Allen Robinson: 6.0% probability
• Darrell Henderson: 5.2% probability

San Francisco 49ers

• Deebo Samuel: 11.5% probability
• Jeff Wilson: 8.3% probability
• Brandon Aiyuk: 7.9% probability
• George Kittle: 6.3% probability
• Jimmy Garoppolo: 5.1% probability

Anytime Touchdown Scorer Probabilities

Los Angeles Rams

• Cooper Kupp: 50.2% probability
• Cam Akers: 33.4% probability
• Tyler Higbee: 31.0% probability
• Allen Robinson: 25.5% probability
• Darrell Henderson: 23.2% probability

San Francisco 49ers

• Deebo Samuel: 44.0% probability
• Jeff Wilson: 35.0% probability
• Brandon Aiyuk: 33.2% probability
• George Kittle: 26.9% probability
• Jimmy Garoppolo: 22.5% probability

Rams-49ers Projected Player Stats

Of the starting quarterbacks, the Rams' Matthew Stafford is projected for 254 passing yards. The 49ers' Jimmy Garoppolo is expected to throw for 236 yards.

Rams Starting QB

• Matthew Stafford: 254 projected yards

49ers Starting QB

• Jimmy Garoppolo: 236 projected yards

Rams Rushing

• Cam Akers: 45 projected yards
• Darrell Henderson: 28 projected yards
• Matthew Stafford: 7 projected yards

49ers Rushing

• Jeff Wilson: 62 projected yards
• Deebo Samuel: 24 projected yards
• Jordan Mason: 20 projected yards

Rams Receiving

• Cooper Kupp: 104 projected yards
• Tyler Higbee: 42 projected yards
• Allen Robinson: 40 projected yards
• Ben Skowronek: 23 projected yards
• Darrell Henderson: 13 projected yards

49ers Receiving

• Brandon Aiyuk: 60 projected yards
• Deebo Samuel: 51 projected yards
• George Kittle: 49 projected yards
• Jauan Jennings: 22 projected yards
• Kyle Juszczyk: 16 projected yards

Remember, DimersBOT updates regularly, so refresh this article for the latest betting insights ahead of Rams vs. 49ers on Monday October 3, 2022.

Rams vs. 49ers 2022

The NFL Week 4 game between the 49ers and Rams at Levi's Stadium is scheduled to begin at 8:15PM ET.

• Who: Los Angeles Rams vs. San Francisco 49ers
• Date: Monday October 3, 2022
• Time: 8:15PM ET / 5:15PM PT
• Venue: Levi's Stadium

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What other NFL games are on today?

The Rams and 49ers aren't the only two NFL teams you can bet on. DimersBOT never stops and we've got picks and best bets for each and every NFL matchup in our NFL Bet Hub page.

Not only do we provide with you top-notch predictions, but we also have recommended bets for the Spread, Over/Under and Moneyline. Sound good? Check it out now!