Purdue vs. Northwestern CFB Predictions and Odds - Nov 20, 2021

Northwestern takes on the favored Purdue in College Football Week 12 action at Wrigley Field on Saturday, commencing at 12:00 PM EST.

Dimers' top betting picks for Purdue vs. Northwestern, as well as game predictions and best odds, are featured below.

Who will win Purdue vs. Northwestern?

Based on advanced machine learning and data, Dimers.com has simulated Saturday's Purdue-Northwestern NCAA Football game 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, gives Purdue a 78% chance of beating Northwestern.

MORE: Purdue vs. Northwestern simulated 10,000 times

Purdue vs. Northwestern Point Spread, Moneyline and Over/Under

Northwestern is listed as the +11.5 underdog against Purdue, with -110 at FanDuel Sportsbook the best odds available.

For the favored Purdue (-11.5) to cover the spread, FanDuel Sportsbook also has the best odds on offer at -110.

DraftKings Sportsbook has the best moneyline odds for Northwestern at +340, which means you can throw down $100 to profit $340, earning a total payout of $440, if it wins.

On the other hand, Caesars Sportsbook has the best moneyline odds for Purdue at -435, where you can risk $435 to win $100, for a total payout of $535, if it comes out on top.

The Over/Under sits at 48.5 with FanDuel Sportsbook, which has the best odds for the Over at -105, as well as the best odds for the Under at -115.

As always, check out all the online sportsbooks that are available in your state for the best College Football odds and lines.

According to DimersBOT, Northwestern (+11.5) is a 51% chance of covering the spread, while the 48.5-point Over/Under is a 55% chance of going Under.

MORE: Predictions for every College Football Week 12 matchup

Best Bets for Purdue vs. Northwestern

• Spread: Northwestern +11.5 at -110 with FanDuel Sportsbook (51% probability)
• Moneyline: Northwestern Win at +340 with DraftKings Sportsbook
• Over/Under: Under 48.5 at -115 with FanDuel Sportsbook (55% probability)

While Purdue is more likely to win the game, according to DimersBOT, betting on Northwestern moneyline is the best option due to the edge found when comparing our data-led probabilities to the sportsbooks' odds.

Taking advantage of the edges seen on Dimers is pivotal to achieving long-term profitability as a bettor.

Purdue vs. Northwestern Score Prediction

Dimers.com's predicted final score for Purdue vs. Northwestern at Wrigley Field on Saturday has Purdue winning 29-18.

Dimers has full betting coverage of this week's Purdue-Northwestern matchup, including pre-game predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates often, so keep checking this article for any changes ahead of Purdue vs. Northwestern on Saturday November 20, 2021.

Purdue vs. Northwestern 2021 CFB Game Info

When does Northwestern play Purdue in College Football?

• Date: Saturday November 20, 2021
• Time: 12:00 PM EST / 9:00 AM PST
• Venue: Wrigley Field

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