Purdue vs. Houston Prediction: Houston Predicted to Win NCAA Tournament Sweet Sixteen Matchup [3/28/2025]

Houston will square off with Purdue in March Madness Sweet Sixteen action at Lucas Oil Stadium on Friday, starting at 10:09PM ET.

Based on updated simulation results, Dimers' proven college basketball model (see Dimers Pro for full access) projects Houston as the most likely winner of today's game.

Check the latest March Madness player prop projections and 2025 NCAA Championship probabilities from our expert team.

"Employing the latest data, our experts simulated Friday's Purdue-Houston game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict Houston's chance of winning is 80%, while Purdue's is 20%."

For expanded analysis of Friday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Purdue vs. Houston predictions page.

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Purdue vs. Houston Prediction: Who Will Win and Advance to the Elite Eight?

Using innovative machine learning and data, we have simulated the result of Friday's NCAA Tournament matchup between Purdue and Houston 10,000 times as part of our March Madness predictions coverage.

Our independent predictive model currently gives Houston an 80% chance of beating Purdue. Our predicted final score has Houston winning 71-63.

According to our model, Purdue (+8.5) has a 51% chance of covering the spread, while the over/under total of 134.5 points has a 53% chance of going over.

Pre-Game Probabilities

Last Updated: 2:34AM, Mar 29

Spread

Over / Under

Moneyline

Purdue

Purdue +8.5

51%

49%

-110

-110

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Houston

Purdue PUR

-110

Purdue +8.5

51%

49%

See Matchup

Houston HOU

-110

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Purdue vs. Houston March Madness Odds

We have researched the best March Madness odds in America for this Sweet 16 game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Boost your betting this month with the top March Madness betting sites and March Madness betting promos, sourced from top sportsbooks and DFS operators.

Purdue vs. Houston Picks and Best Bets

Our model's strongest edge in today's Purdue vs. Houston matchup is on the spread.

Our expert predictions, aligned with the latest odds, reveal the best March Madness picks and March Madness best bets for every game throughout the tournament.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Purdue vs. Houston Game-Day Updates and Essential Details

Friday's college basketball game between Houston and Purdue at Lucas Oil Stadium is scheduled to begin at 10:09PM ET.

• Who: Purdue vs. Houston
• Date: Friday, March 28, 2025
• Time: 10:09PM ET/7:09PM PT
• Venue: Lucas Oil Stadium
• March Madness Stage: Sweet 16

Dimers.com's full preview of Friday's Purdue vs. Houston matchup includes our prediction, picks and the latest betting odds.

Before making any Purdue vs. Houston picks, be sure to check out the latest March Madness predictions and betting advice from Dimers Pro.

Key March Madness Guides and Insights

• Learn about NCAA Championship history and the lowest-seeded team to ever win March Madness
• Get answers to legal questions, including which states you can legally bet on college sports and the minimum age required to place a bet on March Madness
• A breakdown of March Madness futures bets and popular prop bets for the NCAA tournament
• Explore strategy with guides on identifying value bets during the tournament and betting on individual player awards like Tournament MVP
• Understand the tournament format, including how many games are played in March Madness and how venue locations impact teams when playing at neutral sites

Conclusion

We predict Houston, with an 80% win probability, will likely beat Purdue on Friday.

AI and automation have enhanced this article to quickly deliver accurate Purdue vs. Houston insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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