Pittsburgh vs. Syracuse CFB Predictions and Odds - Nov 27, 2021

Syracuse faces the favored Pittsburgh in College Football Week 13 action at Carrier Dome on Saturday, starting at 7:30 PM EST.

Dimers' top betting picks for Pittsburgh vs. Syracuse, plus game predictions and best odds, are detailed below.

Who will win Pittsburgh vs. Syracuse?

Based on advanced computer power and data, Dimers.com has simulated Saturday's Pittsburgh-Syracuse NCAA Football game 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives Pittsburgh a 76% chance of beating Syracuse.

MORE: Pittsburgh vs. Syracuse Simulated 10,000 Times

Pittsburgh vs. Syracuse Point Spread, Moneyline and Over/Under

Syracuse is currently the +12 underdog against Pittsburgh, with -105 at DraftKings Sportsbook the best odds available.

For the favored Pittsburgh (-12) to cover the spread, DraftKings Sportsbook also has the best odds on the market at -115.

DraftKings Sportsbook has the best moneyline odds for Syracuse at +350. That means you can bet $100 to profit $350, earning a total payout of $450, if it wins.

On the other hand, PointsBet has the best moneyline odds for Pittsburgh at -440, where you can risk $440 to win $100, for a total payout of $540, if it comes out on top.

The Over/Under for total points scored sits at 58.5 with PointsBet, which has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, make sure you check all the legal sportbooks that are available in your state for the best College Football odds and lines.

According to DimersBOT, Syracuse (+12) is a 51% chance of covering the spread, while the Over/Under total of 58.5 points is a 53% chance of going Under.

MORE: Live Win Probabilities for All Major College Sports

Best Bets for Pittsburgh vs. Syracuse

• Spread: Syracuse +12 at -105 with DraftKings Sportsbook (51% probability)
• Moneyline: Syracuse Win at +350 with DraftKings Sportsbook (2.0% edge)
• Over/Under: Under 58.5 at -110 with PointsBet (53% probability)

While Pittsburgh is more likely to win the game, according to DimersBOT, betting on Syracuse moneyline is the best option due to the 2.0% edge identified when comparing our data-led probabilities to the sportsbooks' odds.

Taking advantage of the edges published here at Dimers is pivotal to achieving long-term profitability as a sports bettor.

Pittsburgh vs. Syracuse Score Prediction

Dimers.com's predicted final score for Pittsburgh vs. Syracuse at Carrier Dome this Saturday has Pittsburgh winning 35-23.

Use our dynamic widget below to see the latest Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup for more.

Dimers has full coverage of this week's Pittsburgh-Syracuse matchup, including pre-game predictions, best betting picks, and live win probabilities.

Remember, DimersBOT updates frequently, so keep an eye on this page for any changes to our betting insights before Pittsburgh vs. Syracuse on Saturday November 27, 2021.

Pittsburgh vs. Syracuse 2021 CFB Game Info

When does Syracuse play Pittsburgh in College Football?

• Date: Saturday November 27, 2021
• Time: 7:30 PM EST / 4:30 PM PST
• Venue: Carrier Dome

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What other CFB games are on this week?

Now you've got the 411 on Pittsburgh vs. Syracuse, check out the latest betting predictions for all upcoming NCAA Football games in our College Football Bet Hub. There you can find probabilities and odds, as well as our best bets for every single CFB matchup.

Want a pick for the Spread? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!