Pittsburgh vs. Duke CFB Predictions and Odds - Nov 6, 2021

Duke and Pittsburgh meet in Week 10 of the College Football season at Brooks Field at Wallace Wade Stadium on Saturday, starting at 12:00 PM EDT.

Dimers' best betting picks for Pittsburgh vs. Duke, plus our score prediction and best odds, are featured in this article.

Who will win Pittsburgh vs. Duke?

Using high-tech computer power and data, Dimers.com has simulated Saturday's Pittsburgh-Duke matchup 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, gives Pittsburgh a 87% chance of beating Duke.

MORE: Pittsburgh vs. Duke simulated 10,000 times

Pittsburgh vs. Duke Point Spread, Moneyline and Over/Under

Duke is the +21 underdog against Pittsburgh, with -105 at DraftKings Sportsbook the best odds available.

For the favored Pittsburgh (-21) to cover the spread, Caesars Sportsbook has the best odds on offer at -110.

FanDuel Sportsbook has the best moneyline odds for Duke at +980, which means you can bet $100 to profit $980, earning a total payout of $1080, if it wins.

On the other hand, DraftKings Sportsbook has the best moneyline odds for Pittsburgh at -1500, where you can risk $1500 to win $100, for a total payout of $1600, if it comes out on top.

The Over/Under is set at 64 with Caesars Sportsbook, which has the best odds for the Over at -110, while DraftKings Sportsbook has the best odds for the Under at -105.

As always, make sure you check the sportsbooks you can bet with in your state for the best College Football odds and lines.

According to DimersBOT, Duke (+21) is a 52% chance of covering the spread, while the 64-point Over/Under is a 51% chance of going Over.

Best Bets for Pittsburgh vs. Duke

• Spread: Duke +21 at -105 with DraftKings Sportsbook (52% probability)
• Moneyline: Duke Win at +980 with FanDuel Sportsbook (3.9% edge)
• Over/Under: Over 64 at -110 with Caesars Sportsbook (51% probability)

While Pittsburgh is more likely to win the game, according to DimersBOT, betting on Duke moneyline is the best option due to the 3.9% edge found when comparing our data-led probabilities to the sportsbooks' odds.

Taking advantage of the edges published on Dimers.com is one of the keys to achieving long-term profitability as a bettor.

MORE: Live scores and win probabilities for all major sports

Pittsburgh vs. Duke Predicted Score

Dimers.com's predicted score for Pittsburgh vs. Duke at Brooks Field at Wallace Wade Stadium on Saturday has Pittsburgh winning 42-21.

Dimers has full coverage of this week's Pittsburgh-Duke matchup, including pre-game predictions, top betting picks, live win probabilities, and play-by-play updates.

Remember, DimersBOT updates regularly, so refresh this page for any changes before Pittsburgh vs. Duke on Saturday November 6, 2021.

Pittsburgh vs. Duke 2021 CFB Game Info

When does Duke play Pittsburgh?

• Date: Saturday November 6, 2021
• Time: 12:00 PM EDT / 9:00 AM PDT
• Venue: Brooks Field at Wallace Wade Stadium

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