Pirates vs. Reds Prediction and Odds - May 6, 2022

The Cincinnati Reds and Pittsburgh Pirates clash in MLB at Great American Ball Park on Friday, starting at 6:40PM ET.

The Reds will send Connor Overton (0-0, 1.69 ERA) to the mound, while the Pirates will counter with JT Brubaker (0-2, 6.20 ERA).

Dimers' best betting picks for Pirates vs. Reds, as well as game predictions and best odds, are featured below.

This Pittsburgh vs. Cincinnati betting preview is proudly sponsored by PointsBet, which has an awesome 5x $100 Risk-Free Bets offer for new customers.

Who will win Pirates vs. Reds?

Using cutting-edge machine learning and data, Dimers.com has simulated Friday's Pirates-Reds MLB game 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, can't split the two teams, giving both the Pirates and Reds a 50% chance of winning the game.

More: Pirates vs. Reds Simulated 10,000 Times

Pirates vs. Reds Game Odds

• Run Line: Reds +1.5 (-155), Pirates -1.5 (+146)
• Moneyline: Reds +100, Pirates -115
• Total: Over/Under 8.5 (-105/+100)

Run Line, Moneyline and Over/Under

The Reds are +1.5 underdogs against the Pirates, with -155 at DraftKings Sportsbook the best odds currently available.

For the favored Pirates (-1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at +146.

DraftKings Sportsbook currently has the best moneyline odds for the Reds at +100, which means you can risk $100 to win $100, for a total payout of $200, if they get the W.

On the other hand, BetMGM currently has the best moneyline odds for the Pirates at -115, where you can risk $115 to win $100, for a total payout of $215, if they come out on top.

The Over/Under for total runs scored sits at 8.5 with FanDuel Sportsbook, which currently has the best odds for the Over at -105, while BetMGM currently has the best odds for the Under at +100.

As always, check out all the sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Reds (+1.5) are a 63% chance of covering the run line, while the 8.5-run Over/Under is a 51% chance of going Over.

More: Best Bets for Every MLB Game

Best Bets for Pirates vs. Reds

• Run Line: Reds +1.5 @ -155 via DraftKings Sportsbook (63% probability)
• Moneyline: Reds @ +100 via DraftKings Sportsbook (50% probability)
• Total: Over 8.5 @ -105 via FanDuel Sportsbook (51% probability)

Dimers' best bets are based on world-class simulations and betting intelligence to serve you the best possible plays every time.

Pirates vs. Reds Betting Guide

Use our widget below to view the latest Moneyline, Over/Under and Run Line probabilities and odds for Pittsburgh vs. Cincinnati, and click or tap on See Matchup for more.

Dimers has full coverage of Friday's Pirates-Reds matchup, including pregame predictions, best betting picks, and live win probabilities.

Don't forget, DimersBOT updates often, so refresh this article for the latest betting insights before Pirates vs. Reds on Friday May 6, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Pirates vs. Reds 2022 Game Info

When do the Reds play the Pirates?

• Date: Friday May 6, 2022
• Time: 6:40PM ET / 3:40PM PT
• Venue: Great American Ball Park

Ready to join an online sportsbook and start betting on MLB? We've listed the best available sign-up offers in each and every legal betting state.

What other MLB games are on today?

Now you've got the 411 on Pirates vs. Reds, take a look at the latest betting coverage for all upcoming MLB games in our MLB Bet Hub, where you can find probabilities and odds, and our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

While you're here, Dimers' MLB Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities paired with the best odds on the market.