Phillies vs. Cardinals Prediction: Philadelphia Predicted to Win Saturday's MLB Matchup [4/12/2025]

The St. Louis Cardinals will square off with the Philadelphia Phillies in MLB action at Busch Stadium on Saturday, starting at 2:15PM ET.

The Cardinals will have Miles Mikolas (0-1, 11.25 ERA) as their starting pitcher, while the Phillies will counter with Cristopher Sánchez (0-0, 4.09 ERA).

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Phillies as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Philadelphia-St. Louis game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Phillies are more likely to win, while the Cardinals have a lower chance of victory."

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Phillies vs. Cardinals predictions page.

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Phillies vs. Phillies Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the outcome of Saturday's MLB game between the Phillies and Cardinals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Phillies a 58% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 55% chance of covering the run line, while the over/under total of 7.5 runs has a 54% chance of going over.

Pre-Game Probabilities

Last Updated: 6:28PM, Apr 12

Moneyline

Over / Under

Run Line

Phillies

Win %

59%

41%

-175

+160

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Cardinals

Phillies PHI

-175

Win %

59%

41%

See Matchup

Cardinals STL

+160

Cristopher Sánchez 0-0, 4.09 ERA

Miles Mikolas 0-1, 11.25 ERA

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Phillies vs. Cardinals Odds [4/12/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Phillies vs. Cardinals Picks and Best Bets

Our model's strongest edge in today's Phillies vs. Cardinals matchup is on the total.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Phillies vs. Cardinals Game-Day Updates and Essential Details

Saturday's MLB matchup between the Cardinals and Phillies at Busch Stadium is scheduled to start at 2:15PM ET.

• Who: Philadelphia Phillies vs. St. Louis Cardinals
• Date: Saturday, April 12, 2025
• Time: 2:15PM ET/11:15AM PT
• Venue: Busch Stadium

Dimers.com's in-depth preview of Saturday's Phillies vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Philadelphia vs. St. Louis picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Phillies, with a 58% win probability, will likely beat the Cardinals on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Phillies vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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