Phillies vs. Cubs Prediction: Cubs Predicted to Win Friday's MLB Matchup [4/25/2025]

The Chicago Cubs will take on the Philadelphia Phillies in MLB action at Wrigley Field on Friday, commencing at 2:20PM ET.

The Cubs will start Colin Rea (0-0, 1.32 ERA), while the Phillies have opted for Taijuan Walker (1-1, 2.29 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Philadelphia-CHI Cubs game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Cubs' chance of winning is 55%, while the Phillies' is 45%."

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Phillies vs. Cubs predictions page.

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Cubs vs. Phillies Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data analysis, we have simulated the result of Friday's MLB matchup between the Phillies and Cubs 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cubs a 55% chance of beating the Phillies.

According to our model, the Phillies (+1.5) have a 64% chance of covering the run line, while the 7.5-run over/under has a 58% chance of going over.

Pre-Game Probabilities

Last Updated: 5:28PM, Apr 25

Moneyline

Over / Under

Run Line

Phillies

Win %

45%

55%

+136

-158

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Cubs

Phillies PHI

+136

Win %

45%

55%

See Matchup

Cubs CHC

-158

Taijuan Walker 1-1, 2.29 ERA

Colin Rea 0-0, 1.32 ERA

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Phillies vs. Cubs Odds [4/25/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Phillies vs. Cubs Picks and Best Bets

Our model's strongest edge in today's Phillies vs. Cubs matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Phillies vs. Cubs Game-Day Updates and Essential Details

Friday's MLB game between the Cubs and Phillies at Wrigley Field is scheduled to start at 2:20PM ET.

• Who: Philadelphia Phillies vs. Chicago Cubs
• Date: Friday, April 25, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's comprehensive preview of Friday's Phillies vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Philadelphia vs. CHI Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 55% win probability, will likely beat the Phillies on Friday.

AI and automation have enhanced this article to quickly deliver accurate Phillies vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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