76ers vs. Spurs Prediction: San Antonio Predicted to Win Friday's NBA Game [3/21/2025]

The San Antonio Spurs and Philadelphia sixers will lock horns in NBA action at Frost Bank Center on Friday, with tipoff at 8:00PM ET.

Based on updated simulation results and today’s injury news, Dimers' proven NBA model (see Dimers Pro for full access) predicts the Spurs as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Philadelphia-San Antonio game 10,000 times," said Damien Souness from Dimers.

"After computing the latest updates and thousands of other inputs, we predict the Spurs' chance of winning is 70%, while the 76ers' is 30%."

This prediction follows the latest NBA Injury Report, which suggests the Spurs lineup will feature players like Stephon Castle, Devin Vassell and Keldon Johnson, while the 76ers will be led by Quentin Grimes, Jared Butler and Justin Edwards.

For a closer look at Friday's matchup, including an expanded look at the predicted score, best bets and player prop picks, visit our interactive 76ers vs. Spurs predictions page.

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Sixers vs. Sixers Prediction: Who Will Win, Cover the Spread?

Using innovative machine learning and data, we have simulated the result of Friday's NBA matchup between the 76ers and Spurs 10,000 times as part of our NBA predictions coverage.

Our famous predictive model currently gives the Spurs a 70% chance of defeating the 76ers. Our predicted final score has the Spurs winning 119-113.

According to our model, the bookmakers have got it right, and the 76ers and Spurs each have a 50% chance of covering the spread, while the over/under total of 234.5 points has a 54% chance of staying under.

76ers vs. Spurs Odds

We have researched the best NBA odds in America for this game, which are listed here:

Bet Type	76ers	Spurs
Spread	+5.5 (-105)	-5.5 (-115)
Moneyline	+190	-215
Total	o234.5 (-110)	u234.5 (-110)

All odds are correct at the time of publication and are subject to change.

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76ers vs. Spurs Picks and Best Bets

Our model's strongest edge in today's 76ers vs. Spurs matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best NBA picks and NBA best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

76ers vs. Spurs Player Props

NBA prop bets are an exciting way to wager on Friday's Philadelphia vs. San Antonio game without necessarily betting on the outcome. We have crunched the numbers to project how each team's leading players will perform at Frost Bank Center.

Quentin Grimes is expected to lead the 76ers with 18 points, 6 rebounds and 4 assists, while Stephon Castle is projected to have 21 points, 4 rebounds and 5 assists for the Spurs.

Dimers Pro users can access a full range of player props and projected box scores, including points, assists, rebounds and more, for every NBA game this season.

Sixers vs. Spurs Game-Day Updates and Essential Details

Friday's game between the Spurs and 76ers at Frost Bank Center is scheduled to start at 8:00PM ET.

• Who: Philadelphia 76ers vs. San Antonio Spurs
• Date: Friday, March 21, 2025
• Time: 8:00PM ET/5:00PM PT
• Venue: Frost Bank Center

Dimers.com's comprehensive preview of Friday's 76ers vs. Spurs matchup includes our prediction, picks and the latest betting odds.

Before making any Philadelphia vs. San Antonio picks, be sure to check out the latest NBA predictions and betting advice from Dimers Pro.

Conclusion

We predict the Spurs, with a 70% win probability, will likely beat the 76ers on Friday.

AI and automation have enhanced this article to quickly deliver accurate 76ers vs. Spurs insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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