Penn State vs. Ohio State CFB Prediction and Odds - October 21, 2023

Ohio State takes on Penn State in College Football action at Ohio Stadium on Saturday, commencing at 12:00PM ET.

Dimers' prediction for Saturday's Penn State vs. Ohio State matchup, as well as the latest odds and our in-depth game preview, are featured below.

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Who Will Win: Penn State vs. Ohio State

Using cutting-edge machine learning and data, Dimers.com has simulated the outcome of Penn State vs. Ohio State 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, currently gives Ohio State a 64% chance of winning against Penn State.

More: Betting Guide for Penn State vs. Ohio State

Penn State vs. Ohio State Odds

We have researched the best betting odds in America for this game, which are listed here:

• Spread: Ohio State -4.5 (-105), Penn State +4.5 (-115)
• Moneyline: Ohio State -192, Penn State +160
• Total: Over/Under 46 (-110/-110)

Odds are correct at the time of publication and subject to change.

Ohio State is listed as the -4.5 favorite versus Penn State, with -105 at FanDuel Sportsbook the best odds currently available.

For the underdog Penn State (+4.5) to cover the spread, FanDuel Sportsbook also has the best odds currently on offer at -115.

DraftKings Sportsbook currently has the best moneyline odds for Ohio State at -192. That means you can risk $192 to win $100, for a total payout of $292, if it gets the W.

On the other hand, DraftKings Sportsbook also has the best moneyline odds for Penn State at +160, where you can bet $100 to profit $160, earning a total payout of $260, if it wins.

The Over/Under for total points scored is set at 46 with PointsBet, which currently has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, make sure you check the sportsbooks you can bet with in your state for the best College Football odds and lines.

According to DimersBOT, the bookmakers have got it right and both Penn State and Ohio State have a 50% chance of covering the spread, while the 46-point Over/Under also has a 56% chance of going Over.

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More: Free Prop Picks

Best Bets: Penn State vs. Ohio State

• Spread: Ohio State -4.5 @ -105 via FanDuel Sportsbook (50% probability)
• Moneyline: Penn State @ +160 via DraftKings Sportsbook
• Total: Over 46 @ -110 via PointsBet (56% probability)

Dimers' best bets are based on detailed simulations and betting intelligence to serve you the best possible plays every time.

While Ohio State is more likely to win the game, according to DimersBOT, taking Penn State moneyline is the best option due to the edge found when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges seen on Dimers.com is one of the keys to being a profitable bettor in the long run.

Penn State vs. Ohio State Prediction

Dimers.com's predicted final score for Penn State vs. Ohio State at Ohio Stadium on Saturday has Ohio State winning 26-21.

Click or tap on See Matchup to find out more.

Dimers has full coverage of this week's Penn State vs. Ohio State game, including pregame predictions, free picks, and live win probabilities.

Remember, DimersBOT updates frequently, so refresh this page for the latest betting insights before Penn State vs. Ohio State on Saturday October 21, 2023.

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Penn State vs. Ohio State Preview

Saturday's action between Ohio State and Penn State in College Football at Ohio Stadium is scheduled to start at 12:00PM ET.

• Who: Penn State vs. Ohio State
• Date: Saturday October 21, 2023
• Time: 12:00PM ET / 9:00AM PT
• Venue: Ohio Stadium

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Conclusion

This extensive game preview includes our Penn State vs. Ohio State prediction and College Football odds.

Dimers' picks are based on 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods.

While these Penn State vs. Ohio State picks can help you make informed decisions, it's crucial that you gamble responsibly and manage your bankroll effectively.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

What College Football Games Are on This Week?

Penn State and Ohio State aren't the only two NCAA Football teams you can bet on today. DimersBOT never stops and we've got picks and top bets for every single CFB game via our College Football predictions. Not only do we provide with you top-notch predictions, but we also have recommended bets for the Spread, Over/Under and Moneyline. Sound good? Check it out now!

In addition to our leading CFB predictions, we also feature the best CFB prop bets today, projecting passing yards, touchdowns, and more against the top odds available every single day of the CFB season.