Padres vs. Phillies Computer Picks, MLB Odds and Betting Lines for October 21, 2022

The NLCS rolls into Philadelphia with the series delicately poised at 1-1. Who takes the advantage from here?

It's Friday, October 21, 2022, and, as always, we've simulated all of the day's MLB games 10,000 times each to determine where the value lies for sports bettors across the United States.

With our MLB best bets, probabilities, and odds featured each and every day, check out our best betting picks for Friday's MLB games below.

Today's best MLB prop bets and odds are proudly brought to you by DraftKings Sportsbook.

If you’re looking to bet on baseball, then you should consider signing up with DraftKings ➡️ here ⬅️ where you can turn a $5 moneyline bet on any game into a free $200 instantly if it hits. You know you’ll be on the couch watching the games anyway, so why not take this free money from one of the best sportsbooks on the planet?

Best MLB Bet Today

Padres vs. Phillies, 7:37PM ET

It really is anyone's series here as we begin the weekend in Philly. Starting on the mound for Game 3 will be Joe Musgrove for the Padres, while the Phillies will give the ball to left-hander Ranger Suarez. On form, Musgrove has looked pretty damn good, giving up just a 0.95 ERA over his last three starts - which have all been wins, against the likes of the Dodgers, Mets and Giants.

Suarez's form has not been that great in contrast. He's operating on a 6.57 ERA over the same span, going 0-2 and giving up an obscene 12.41 hits per 9. That's going to be a key for this San Diego team who will be focused on getting the ball into play against Suarez. The Friars strikeout significantly less against lefties this season (averaging just 3 strikeouts per game against lefties compared with 6 against right-handers). If the San Diego hitting lineup can get on base, they'll breakdown this Philly defense while Musgrove can go to work on their hitters. We've got the Padres taking the series lead.

BET: Padres moneyline (-116). Want to tail this pick? Do it with DraftKings Sportsbook and get a nice bonus while doing so by clicking ➡️ here ⬅️.

Best MLB Prop Today

With Ranger Suarez giving up an average of more than 12 hits per 9 innings, and an average of 5 hits per start over the course of the year, the plus money on offer for the Padres to register more hits than the Phillies is obscene value. We're taking advantage of what could be a high scoring run total from San Diego.

BET: Padres Most Hits (+110). Want to tail this pick? Do it with DraftKings Sportsbook and get a nice bonus while doing so by clicking ➡️ here ⬅️.

⚾️ Padres vs. Phillies Predictions
✍🏼 Betting Preview: Padres vs. Phillies

Visit our MLB Bet Hub, where we deliver you MLB predictions and suggested bets, or check out the MLB Betting News section.

Best MLB Same Game Parlay Today

There are numerous different ways you can wager on MLB games in 2022, such as the moneyline, run line, total, player and team props (strikeouts, RBIs, and home runs), and, of course, parlays. Given the high-risk, high reward nature of parlays, we're going to use the DraftKings Bet $5, win $200 no matter what promo to guarantee a big cash.

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🔥 Padres ML
🔥 Manny Machado 1+ Hit
🔥 Juan Soto 1+ Hit
🔥 Ha-Seong Kim 1+ Hit

*All odds and lines correct at time of publishing