Orioles vs. Guardians Prediction for MLB Thursday [9/21/2023]

MLB action continues on Thursday at 7:15PM ET as the Baltimore Orioles take on the Cleveland Guardians at Progressive Field.

Hunter Gaddis (2-1, 4.85 ERA) will be on the bump for the Guardians, up against Grayson Rodriguez (6-4, 4.53 ERA) for the Orioles.

Dimers' top betting picks for Orioles vs. Guardians, plus game predictions and best odds, are detailed in this article.

Who Will Win: Orioles vs. Guardians

Based on trusted computer power and data, Dimers.com has simulated Thursday's Orioles-Guardians MLB game 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, currently gives the Orioles a 60% chance of getting the W against the Guardians.

More: Betting Analysis for Orioles vs. Guardians

Orioles vs. Guardians Odds [9/21]

• Run Line: Guardians +1.5 (-120), Orioles -1.5 (+102)
• Moneyline: Guardians +136, Orioles -155
• Total: Over/Under 8 (-108/+100)

The Guardians are currently +1.5 underdogs against the Orioles, with -120 at PointsBet the best odds currently available.

For the favored Orioles (-1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on offer at +102.

FanDuel Sportsbook currently has the best moneyline odds for the Guardians at +136, which means you can bet $100 to profit $136, earning a total payout of $236, if they win.

Meanwhile, DraftKings Sportsbook currently has the best moneyline odds for the Orioles at -155, where you can risk $155 to win $100, for a total payout of $255, if they come out on top.

The Over/Under for total runs scored is set at 8 with DraftKings Sportsbook, which currently has the best odds for the Over at -108, while BetMGM currently has the best odds for the Under at +100.

As always, check out the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) have a 52% chance of covering the run line, while the Over/Under total of 8 runs has a 61% chance of going Over.

More: Free Prop Picks

Best Bets: Orioles vs. Guardians

• Run Line: Orioles -1.5 @ +102 via DraftKings Sportsbook
• Moneyline: Orioles @ -155 via DraftKings Sportsbook (60% probability)
• Total: Over 8 @ -108 via DraftKings Sportsbook (61% probability) 🔥

Every time you see a 🔥, that means you've found one of our best free picks today across any sport.

Dimers' best bets are based on detailed simulations and gambling intelligence to serve you the best possible plays 24/7/365.

Although the Guardians are more likely to cover the run line, our best bet of Orioles -1.5 is based on the likelihood of that happening, according to DimersBOT, and the best odds available.

Orioles vs. Guardians Prediction

Dimers.com predicts that the Orioles are more likely to defeat the Guardians at Progressive Field on Thursday.

This prediction is based on extensive data-driven analysis, with the Orioles given a 60% chance of winning after conducting 10,000 game simulations.

Click or tap on See Matchup for more information.

Dimers has full betting coverage of Thursday's Orioles-Guardians game, including pregame predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates frequently, so keep an eye on this page for any changes to our betting insights before Orioles vs. Guardians on Thursday September 21, 2023.

Orioles vs. Guardians 2023

Thursday's MLB action between the Guardians and Orioles at Progressive Field is scheduled to begin at 7:15PM ET.

• Who: Baltimore Orioles vs. Cleveland Guardians
• Date: Thursday September 21, 2023
• Time: 7:15PM ET / 4:15PM PT
• Venue: Progressive Field

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Our picks are based on 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods.

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What Other MLB Games Are on Today?

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