Orioles vs. Guardians Prediction for MLB Friday [9/22/2023]

The Cleveland Guardians will square off with the Baltimore Orioles in MLB action at Progressive Field on Friday, commencing at 7:10PM ET.

The Guardians will have Shane Bieber (5-6, 3.77 ERA) as their starting pitcher, pitting him against Dean Kremer (12-5, 4.17 ERA) for the Orioles.

Dimers' top betting picks for Orioles vs. Guardians, plus game predictions and best odds, are detailed below.

Who Will Win: Orioles vs. Guardians

Using high-tech machine learning and data, Dimers.com has simulated Friday's Orioles-Guardians MLB game 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, gives the Guardians a 53% chance of winning against the Orioles.

More: Orioles vs. Guardians Simulated 10,000 Times

Orioles vs. Guardians Odds [9/22]

• Run Line: Guardians +1.5 (-196), Orioles -1.5 (+164)
• Moneyline: Guardians -120, Orioles +102
• Total: Over/Under 8 (-110/-108)

The Guardians are +1.5 underdogs against the Orioles, with -196 at FanDuel Sportsbook the best odds currently available.

For the favored Orioles (-1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on offer at +164.

PointsBet currently has the best moneyline odds for the Guardians at -120, which means you can risk $120 to win $100, for a total payout of $220, if they get the W.

Elsewhere, FanDuel Sportsbook currently has the best moneyline odds for the Orioles at +102, where you can bet $100 to profit $102, earning a total payout of $202, if they win.

The Over/Under is set at 8 with PointsBet, which currently has the best odds for the Over at -110, while DraftKings Sportsbook currently has the best odds for the Under at -108.

As always, make sure you check the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) have a 64% chance of covering the run line, while the Over/Under total of 8 runs has a 59% chance of going Over.

More: Live Win Probabilities for All Major Sports

Best Bets: Orioles vs. Guardians

• Run Line: Orioles -1.5 @ +164 via DraftKings Sportsbook
• Moneyline: Guardians @ -120 via PointsBet (53% probability)
• Total: Over 8 @ -110 via PointsBet (59% probability) 🔥

If you see a 🔥, you know it's one of Dimers' best bets today across all sports.

Our best bets are based on detailed simulations and betting intelligence to serve you the best possible plays every time.

Although the Guardians are more likely to cover the run line, our best bet of Orioles -1.5 is based on the expectation of that happening, according to DimersBOT, and the best odds available.

Orioles vs. Guardians Prediction

Dimers.com predicts that the Guardians are more likely to beat the Orioles in the MLB game on Friday.

This prediction is backed by detailed data-driven analysis, with the Guardians boasting a 53% chance of winning after conducting 10,000 simulations of the game.

Click or tap on See Matchup for more information.

Dimers has full betting coverage of Friday's Orioles-Guardians game, including pregame predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so refresh this page for any changes to our betting analysis ahead of Orioles vs. Guardians on Friday September 22, 2023.

Orioles vs. Guardians 2023

Friday's MLB matchup between the Guardians and Orioles at Progressive Field is scheduled to commence at 7:10PM ET.

• Who: Baltimore Orioles vs. Cleveland Guardians
• Date: Friday September 22, 2023
• Time: 7:10PM ET / 4:10PM PT
• Venue: Progressive Field

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Dimers' picks are based on 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods.

While these Orioles vs. Guardians predictions can help you make informed decisions, it's vital that you gamble responsibly and manage your bankroll effectively.

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