Ohio State vs. Michigan CFB Predictions and Odds - Nov 27, 2021

Michigan squares off with the favored Ohio State in College Football Week 13 action at Michigan Stadium on Saturday, starting at 12:00 PM EST.

Dimers' best betting picks for Ohio State vs. Michigan, plus game predictions and best odds, are detailed in this article.

Who will win Ohio State vs. Michigan?

Using cutting-edge computer power and data, Dimers.com has simulated Saturday's Ohio State-Michigan NCAA Football matchup 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, gives Ohio State a 65% chance of beating Michigan.

MORE: Free Betting Guide for Ohio State vs. Michigan

Ohio State vs. Michigan Point Spread, Moneyline and Over/Under

Michigan is the +7.5 underdog against Ohio State, with -110 at FanDuel Sportsbook the best odds available.

For the favored Ohio State (-7.5) to cover the spread, FanDuel Sportsbook also has the best odds on offer at -110.

Caesars Sportsbook has the best moneyline odds for Michigan at +220. That means you can bet $100 to profit $220, earning a total payout of $320, if it wins.

Meanwhile, PointsBet has the best moneyline odds for Ohio State at -260, where you can risk $260 to win $100, for a total payout of $360, if it comes out on top.

The Over/Under is set at 63.5 with FanDuel Sportsbook, which has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, make sure you check all the online sportsbooks available in your state for the best College Football odds and lines.

According to DimersBOT, Michigan (+7.5) is a 55% chance of covering the spread, while the Over/Under total of 63.5 points is a 52% chance of going Over.

MORE: Live Win Probabilities for All Major College Sports

Best Bets for Ohio State vs. Michigan

• Spread: Michigan +7.5 at -110 with FanDuel Sportsbook (55% probability)
• Moneyline: Michigan Win at +220 with Caesars Sportsbook (4.2% edge) 🔥
• Over/Under: Over 63.5 at -110 with FanDuel Sportsbook (52% probability)

If you see a 🔥, that means you've found one of Dimers' best free picks of the day across all major pro and college sports.

While Ohio State is more likely to win the game, according to DimersBOT, betting on Michigan moneyline is the best option due to the 4.2% edge found when comparing our data-led probabilities to the sportsbooks' odds.

Taking advantage of the edges seen here at Dimers is crucial to being profitable in the long run.

Ohio State vs. Michigan Score Prediction

Dimers.com's predicted final score for Ohio State vs. Michigan at Michigan Stadium this Saturday has Ohio State winning 35-28.

Use our dynamic widget below to explore the latest Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup for more.

Dimers has full coverage of this week's Ohio State-Michigan matchup, including pre-game predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates often, so check this page for any changes to our betting insights before Ohio State vs. Michigan on Saturday November 27, 2021.

Ohio State vs. Michigan 2021 CFB Game Info

When does Michigan play Ohio State in College Football?

• Date: Saturday November 27, 2021
• Time: 12:00 PM EST / 9:00 AM PST
• Venue: Michigan Stadium

Looking to join an online sportsbook and start betting on College Football now? Check out the top sportsbook promos in your state.

What other CFB games are on this week?

Now you've got the 411 on Ohio State vs. Michigan, check out the latest betting predictions for all upcoming NCAA Football games in our College Football Bet Hub. There you can find probabilities and odds, plus our best bets for every single CFB matchup.

Want a pick for the Spread? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!