Notre Dame vs. Southern California CFB Prediction and Odds - Nov 26, 2022

Southern California and Notre Dame meet in College Football action at Los Angeles Memorial Coliseum on Saturday, with kickoff at 7:30PM ET.

Dimers' free betting picks for Notre Dame vs. Southern California, as well as game predictions and betting odds, are featured below.

Who will win Notre Dame vs. Southern California?

Using advanced machine learning and data, Dimers.com has simulated Notre Dame vs. Southern California 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, gives Southern California a 62% chance of winning against Notre Dame.

More: Notre Dame vs. Southern California Simulated 10,000 Times

Notre Dame vs. Southern California Game Odds

• Spread: Southern California -4 (-110), Notre Dame +4 (-110)
• Moneyline: Southern California -180, Notre Dame +170
• Total: Over/Under 63 (-115/-105)

Point Spread, Moneyline and Over/Under

Southern California is listed as the -4 favorite against Notre Dame, with -110 at DraftKings Sportsbook the best odds currently available.

For the underdog Notre Dame (+4) to cover the spread, DraftKings Sportsbook also has the best odds currently on the market at -110.

DraftKings Sportsbook currently has the best moneyline odds for Southern California at -180. That means you can risk $180 to win $100, for a total payout of $280, if it gets the W.

On the other hand, PointsBet currently has the best moneyline odds for Notre Dame at +170, where you can bet $100 to profit $170, earning a total payout of $270, if it wins.

The Over/Under sits at 63 with DraftKings Sportsbook, which currently has the best odds for the Over at -115, as well as the best odds for the Under at -105.

As always, check out all of the legal sportbooks that are available in your state for the best College Football odds and lines.

According to DimersBOT, Southern California (-4) is a 53% chance of covering the spread, while the Over/Under total of 63 points is a 53% chance of going Under.

More: Free Online Bet Tracking Tool

Best Bets for Notre Dame vs. Southern California

• Spread: Southern California -4 @ -110 via DraftKings Sportsbook (53% probability)
• Moneyline: Notre Dame @ +170 via PointsBet (0.8% edge)
• Total: Under 63 @ -105 via DraftKings Sportsbook (53% probability)

Our best bets are based on world-class modeling and betting intelligence to bring you the best possible plays 24/7/365.

While Southern California is more likely to win the game, according to DimersBOT, taking Notre Dame moneyline is the best option due to the edge identified when comparing our data-led probabilities to the betting odds currently on offer.

Taking advantage of the edges published on Dimers.com is one of the keys to achieving long-term profitability.

Notre Dame vs. Southern California Prediction

Dimers.com's predicted final score for Notre Dame vs. Southern California at Los Angeles Memorial Coliseum on Saturday has Southern California prevailing 33-27.

Click or tap on See Matchup for more.

Dimers has full betting coverage of this week's Notre Dame-Southern California matchup, including pregame predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates frequently, so refresh this page for any changes to our betting insights before Notre Dame vs. Southern California on Saturday November 26, 2022.

Notre Dame vs. Southern California 2022 CFB Game Info

Saturday's matchup between Southern California and Notre Dame in College Football at Los Angeles Memorial Coliseum is scheduled to start at 7:30PM ET.

• Who: Notre Dame vs. Southern California
• Date: Saturday November 26, 2022
• Time: 7:30PM ET / 4:30PM PT
• Venue: Los Angeles Memorial Coliseum

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