Notre Dame vs. Clemson Prediction: Clemson Predicted to Win College Basketball Matchup [2/26/2025]

Clemson and Notre Dame will lock horns in college basketball action at Littlejohn Coliseum on Wednesday, starting at 7:00PM ET.

Based on the latest simulation results, Dimers' proven college basketball model (see Dimers Pro for full access) projects Clemson as the most likely winner of today's game.

Check the latest March Madness bracket projections and 2025 NCAA Championship probabilities.

"Our team has simulated the outcome of Wednesday's Notre Dame-Clemson game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate Clemson's chance of winning at 91%, with Notre Dame at 9%."

For a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Notre Dame vs. Clemson predictions page.

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Notre Dame vs. Clemson Prediction: Who Will Win, Cover the Spread?

Using trusted machine learning and data, we have simulated the outcome of Wednesday's NCAA basketball game between Notre Dame and Clemson 10,000 times as part of our college basketball predictions coverage.

Our leading predictive model gives Clemson a 91% chance of defeating Notre Dame. Our predicted final score has Clemson winning 77-62.

According to our model, the bookmakers have got it right, and Notre Dame and Clemson each have a 50% chance of covering the spread, while the over/under total of 136.5 points has a 55% chance of going over.

Pre-Game Probabilities

Last Updated: 11:32PM, Feb 26

Spread

Over / Under

Moneyline

Notre Dame

Notre Dame +14.5

50%

50%

-110

-102

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Clemson

Notre Dame ND

-110

Notre Dame +14.5

50%

50%

See Matchup

Clemson CLEM

-102

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Notre Dame vs. Clemson Odds

We have researched the best College Basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Notre Dame vs. Clemson Picks and Best Bets

Our model's strongest edge in today's Notre Dame vs. Clemson matchup is on the spread.

Our expert predictions, matched against the best odds, reveal the best college basketball picks for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Notre Dame vs. Clemson Game-Day Updates and Essential Details

Wednesday's college basketball game between Clemson and Notre Dame at Littlejohn Coliseum is scheduled to commence at 7:00PM ET.

• Who: Notre Dame vs. Clemson
• Date: Wednesday, February 26, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: Littlejohn Coliseum

Dimers.com's comprehensive preview of Wednesday's Notre Dame vs. Clemson matchup includes our prediction, picks and the latest betting odds.

Before making any Notre Dame vs. Clemson picks, be sure to check out the latest college basketball predictions and betting advice from Dimers Pro.

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Conclusion

We predict Clemson, with a 91% win probability, will likely beat Notre Dame on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Notre Dame vs. Clemson insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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