Penrith Panthers vs. North QLD Cowboys Prediction: Panthers Predicted to Win Friday's NRL Round 5 Matchup [4/4/2025]

The Penrith Panthers will face the North QLD Cowboys in National Rugby League (NRL) action at Panthers Stadium on Friday, beginning at 3:00AM ET.

Based on the latest simulations, Dimers' proven NRL model (see Dimers Pro for full access) projects the Panthers as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Cowboys-Panthers game 10,000 times," said Pat Sharyon from Dimers.

"After computing the latest updates and thousands of other inputs, we predict the Panthers' chance of winning is 83%, while the Cowboys' is 17%."

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Cowboys vs. Panthers predictions page.

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Panthers vs. Cowboys Prediction: Who Will Win Round 5 Game?

Using powerful machine learning and data, we have simulated the result of Friday's NRL matchup between the Cowboys and Panthers 10,000 times as part of our NRL predictions coverage.

Our independent predictive model gives the Panthers an 83% chance of beating the Cowboys.

According to our model, the Panthers (-13.5) have a 53% chance of covering the spread, while the 49.5- over/under has a 57% chance of staying under.

Pre-Game Probabilities

Last Updated: 8:44AM, Apr 4

Moneyline

Spread

Over / Under

Cowboys

Win %

61%

39%

+325

-455

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See Matchup

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Panthers

Cowboys NQL

+325

Win %

61%

39%

See Matchup

Panthers PEN

-455

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Cowboys vs. Panthers Odds

We have sourced the best NRL odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Panthers vs. Cowboys Game-Day Updates and Essential Details

Friday's Australian rugby league game between the Panthers and Cowboys at Panthers Stadium is scheduled to begin at 3:00AM ET.

• Who: North QLD Cowboys vs. Penrith Panthers
• Date: Friday, April 4, 2025
• Time: 3:00AM ET/12:00AM PT
• Venue: Panthers Stadium

The NRL is available to bet on in the US through all major sportsbooks, with there even being games played in Vegas each season as of 2024.

Dimers.com's comprehensive preview of Friday's Cowboys vs. Panthers matchup includes our prediction, picks and the latest betting odds.

Before making any Cowboys vs. Panthers picks, be sure to check out the latest NRL predictions and betting advice from Dimers Pro.

Conclusion

We predict the Panthers, with an 83% win probability, will likely beat the Cowboys on Friday.

AI and automation have enhanced this article to quickly deliver accurate Cowboys vs. Panthers insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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