North Carolina vs. South Carolina CFB Predictions and Odds - Dec 30, 2021

South Carolina and North Carolina meet in the 2021 Duke's Mayo Bowl at Bank of America Stadium on Thursday, commencing at 11:30AM EST.

Dimers' top betting picks for North Carolina vs. South Carolina, plus game predictions and best odds, are featured in this article.

Who will win the 2021 Duke's Mayo Bowl?

Using cutting-edge machine learning and data, Dimers.com has simulated the 2021 Duke's Mayo Bowl 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives North Carolina a 77% chance of winning against South Carolina.

MORE: North Carolina vs. South Carolina Simulated 10K Times

Point Spread, Moneyline and Over/Under

South Carolina is the +9 underdog against North Carolina, with -110 at BetMGM the best odds available.

For the favored North Carolina (-9) to cover the spread, BetMGM also has the best odds on offer at -110.

Caesars Sportsbook has the best moneyline odds for South Carolina at +270. That means you can throw down $100 to profit $270, earning a total payout of $370, if it wins.

On the other hand, BetMGM has the best moneyline odds for North Carolina at -333, where you can risk $333 to win $100, for a total payout of $433, if it comes out on top.

The Over/Under sits at 57.5 with BetMGM, which has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, make sure you check all the legal sportbooks available in your state for the best College Football odds and lines.

According to DimersBOT, South Carolina (+9) is a 52% chance of covering the spread, while the 57.5-point Over/Under is a 53% chance of going Under.

MORE: Predictions for Every CFB Game

Best Bets for North Carolina vs. South Carolina

• Spread: South Carolina +9 at -110 with BetMGM (52% probability)
• Moneyline: South Carolina Win at +270 with Caesars Sportsbook (6.6% edge) 🔥
• Over/Under: Under 57.5 at -110 with BetMGM (53% probability)

If you see a 🔥, you know it's one of Dimers' best free picks today across all major pro and college sports.

While North Carolina is more likely to win the game, according to DimersBOT, betting on South Carolina moneyline is the best option because of the 6.6% edge found when comparing our data-led probabilities to the sportsbooks' odds.

Taking advantage of the edges seen on Dimers is one of the keys to achieving long-term profitability as a sports bettor.

Duke's Mayo Bowl Score Prediction

Dimers.com's predicted final score for North Carolina vs. South Carolina at Bank of America Stadium this Thursday has North Carolina winning 34-22.

Use our interactive widget below to view the current Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup to reveal more.

Dimers has full coverage of this week's North Carolina-South Carolina matchup, including pre-game predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates often, so check this page for any changes to our betting insights before North Carolina vs. South Carolina on Thursday December 30, 2021.

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North Carolina vs. South Carolina 2021 CFB Game Info

When does South Carolina play North Carolina in College Football?

• Date: Thursday December 30, 2021
• Time: 11:30AM EST / 8:30AM PST
• Venue: Bank of America Stadium

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