NFL Picks Straight Up: Week 12, 2023

Dimers.com provides weekly NFL picks straight up as part of our NFL Picks coverage.

Week 12 of the NFL season is upon us, and we've used our sophisticated predictive analytics model to give you straight up NFL picks for all 16 games this week.

Gain the edge in NFL pick 'em competitions via our data-driven NFL picks for Week 12 of the 2023 NFL season. These picks are based on over 10,000 simulations of every NFL game.

There are 16 games on the slate for Week 12 of the 2023 NFL season, beginning with three big games on Thanksgiving and ending with the Chicago Bears taking on the Minnesota Vikings on Monday night.

These straight up picks for Week 12 are proudly sponsored by Bet365, which has a Bet $5, Get $150 in Bonus Bets offer for new users.

Simply bet $5 on any of the NFL picks below to receive $150 in bonus bets to use on the rest of the Week 12 NFL slate!

See below for a full breakdown of how likely each team is to win in Week 12 of the NFL.

Straight Up NFL Picks - Week 12

Here are our Week 12 NFL predictions, which show the chances of each NFL team winning its game this week.

Green Bay Packers vs. Detroit Lions

The Packers play the Lions at Ford Field on Thursday to start Week 12. According to our model, the Lions have a 75% chance of winning, while the Packers have a 25% chance.

When looking at player props for the opening game of Week 2, our model projects AJ Dillon (RB) as the most likely player from the Packers to score the first TD in the game with a probability of 7.4%, while David Montgomery (RB) is the most likely from the Lions at 11.0%.

Green Bay Packers vs. Detroit Lions is at Ford Field on Thursday, November 23 at 12:30pm EST.

All times mentioned in this article are in Eastern Standard Time (EST).

Washington Commanders vs. Dallas Cowboys

In this week's game between the Commanders and the Cowboys, Dallas is more likely to win. Our prediction model gives the Cowboys an 84% chance of winning. On the other hand, there is a 16% chance that the Commanders will pull off an upset win.

Washington Commanders vs. Dallas Cowboys is at AT&T Stadium on Thursday, November 23 at 4:30pm.

MORE: Super Bowl Odds

San Francisco 49ers vs. Seattle Seahawks

We are picking the 49ers to win their game against the Seahawks this week, with our powerful NFL model projecting a 73% win probability for the road team. The Seahawks have a 27% chance of winning at Lumen Field.

If you're looking to bet on this clash, Bet365 has the Seahawks listed as +6.5 underdogs, whilst the 49ers' moneyline odds are at -290.

San Francisco 49ers vs. Seattle Seahawks is at Lumen Field on Thursday, November 23 at 8:20pm.

Miami Dolphins vs. New York Jets

According to our predictive analytics model, the Dolphins are the team to beat in this game, with their win probability at 86%. The Jets, on the other hand, have a 14% chance of winning.

Miami Dolphins vs. New York Jets is at MetLife Stadium on Friday, November 24 at 3:00pm.

MORE: NFL Best Bets

Jacksonville Jaguars vs. Houston Texans

The Jaguars have a 60% chance of winning on Sunday afternoon, compared to the Texans' 40% chance of victory. This makes the Jacksonville Jaguars our pick to win at NRG Stadium.

Jacksonville Jaguars vs. Houston Texans is at NRG Stadium on Sunday, November 26 at 1:00pm.

Pittsburgh Steelers vs. Cincinnati Bengals

The Steelers are favorites to win here, with our predictive analytics model giving them a 51% chance, while the Bengals enter the weekend with a 49% chance of securing a win at Paycor Stadium.

When it comes to betting on this game, Bet365 has the Steelers' moneyline odds set at -108, with the home team Bengals listed as +1 underdogs.

Pittsburgh Steelers vs. Cincinnati Bengals is at Paycor Stadium on Sunday, November 26 at 1:00pm.

Carolina Panthers vs. Tennessee Titans

After 10,000 simulations of Panthers vs. Titans this Sunday, our model projects the Titans as the more likely winners with a probability of 63%. Their opponents the Panthers have a 37% chance of getting the win on the road.

Carolina Panthers vs. Tennessee Titans is at Nissan Stadium on Carolina, November 26 at 1:00pm.

MORE: NFL Player Props

New Orleans Saints vs. Atlanta Falcons

We are picking the Saints in this matchup, with the Saints given a 57% chance of winning, while the Falcons have a 43% win probability.

New Orleans Saints vs. Atlanta Falcons is at Mercedes-Benz Stadium on Sunday, November 26 at 1:00pm.

Tampa Bay Buccaneers vs. Indianapolis Colts

The next game of Week 12 sees the Buccaneers take on the Colts at Lucas Oil Stadium.

We are predicting the Colts to win with projected win chance of 56%, while the Buccaneers are projected to have a win chance of 44%.

As for the Vegas betting odds here, Bet365 has the Colts listed as -2.5 favorites, with the Buccaneers' moneyline odds posted at +115.

Tampa Bay Buccaneers vs. Indianapolis Colts is at Lucas Oil Stadium on Sunday, November 26 at 1:00pm.

New England Patriots vs. New York Giants

The likely winner of this matchup is the Patriots who have a projected win chance of 70% according to DimersBOT. On the other side of this matchup, the Giants have a projected win probability of 30%.

New England Patriots vs. New York Giants is at MetLife Stadium on Sunday, November 26 at 1:00pm.

MORE: Best NFL Bets Today

Cleveland Browns vs. Denver Broncos

We have run our powerful NFL model over this week’s Browns-Broncos clash 10,000 times, with the Broncos coming out as the team to pick. Of those 10,000 simulations, the Broncos won 6,049 times, with the Browns winning on 3,951 occasions.

Cleveland Browns vs. Denver Broncos is at Empower Field at Mile High on Sunday, November 26 at 4:05pm.

Los Angeles Rams vs. Arizona Cardinals

Next up is the game between the Rams and Cardinals, with our model projecting the road team as the more likely victor, with Rams rated as a 55% chance of getting the W. The Cardinals on the other hand are projected to have a 45% chance of winning.

For those interested in betting on this matchup, Bet365 has the Rams' moneyline odds set at -115 for this road game, whilst the hosting Cardinals are listed as +1 underdogs.

Los Angeles Rams vs. Arizona Cardinals is at State Farm Stadium on Sunday, November 26 at 4:05pm.

Buffalo Bills vs. Philadelphia Eagles

Our next straight up pick this week is for the Eagles to get the win against the Bills. After running 10,000 simulations of this matchup, the Philadelphia have a win probability of 64%, with the Bills at 36%.

Buffalo Bills vs. Philadelphia Eagles is at Lincoln Financial Field on Sunday, November 26 at 4:25pm.

Kansas City Chiefs vs. Las Vegas Raiders

With a win probability of 83% on Sunday afternoon, our straight up pick for this game is the Chiefs, while their opponent, the Raiders, have a projected win chance of 17%.

Kansas City Chiefs vs. Las Vegas Raiders is at Allegiant Stadium on Sunday, November 26 at 4:25pm.

MORE: NFL Player Prop Picks for Week 12

Baltimore Ravens vs. Los Angeles Chargers

The team to pick here is the Ravens who have a 60% chance of winning their matchup against the Chargers this Sunday night.

Looking at the betting odds for this Sunday Night Football clash, Bet365 has the Chargers listed as +4.5 underdogs at home, with the Ravens' moneyline odds available at -200.

Baltimore Ravens vs. Los Angeles Chargers is at SoFi Stadium on Sunday, November 26 at 8:20pm.

Chicago Bears vs. Minnesota Vikings

Our pick to win the final game of Week 12 is Vikings, who have a win probability of 64%. Their opponents are projected to have a 36% chance of getting the W.

Chicago Bears vs. Minnesota Vikings is at U.S. Bank Stadium on Monday, November 27 at 8:15pm.

NFL Picks This Week Straight Up [Week 12, 2023]

• Lions (75% win probability)
• Cowboys (84%)
• 49ers (73%)
• Dolphins (86%)
• Jaguars (60%)
• Steelers (51%)
• Titans (63%)
• Saints (57%)
• Colts (56%)
• Patriots (70%)
• Broncos (60%)
• Rams (55%)
• Eagles (64%)
• Chiefs (83%)
• Ravens (60%)
• Vikings (64%)

NFL Week 12 Slate and Game Times

• Packers vs. Lions (Thursday, 12:30PM ET)
• Commanders vs. Cowboys (Thursday, 4:30PM ET)
• 49ers vs. Seahawks (Thursday, 8:20PM ET)
• Dolphins vs. Jets (Friday, 3:00PM ET)
• Jaguars vs. Texans (Sunday, 1:00PM ET)
• Steelers vs. Bengals (Sunday, 1:00PM ET)
• Panthers vs. Titans (Sunday, 1:00PM ET)
• Saints vs. Falcons (Sunday, 1:00PM ET)
• Buccaneers vs. Colts (Sunday, 1:00PM ET)
• Patriots vs. Giants (Sunday, 1:00PM ET)
• Browns vs. Broncos (Sunday, 4:05PM ET)
• Rams vs. Cardinals (Sunday, 4:05PM ET)
• Bills vs. Eagles (Sunday, 4:25PM ET)
• Chiefs vs. Raiders (Sunday, 4:25PM ET)
• Ravens vs. Chargers (Sunday, 8:20PM ET)
• Bears vs. Vikings (Monday, 8:15PM ET)

All times mentioned in this article are in Eastern Standard Time (EST).

NFL Week 12 Bye Schedule: Who Has a Bye This Week?

All 32 teams are set to play in Week 12 of the 2023 NFL season, which means no team has a bye this week.

NFL Straight Up Picks and Predictions - Week 12

The NFL Week 12 picks straight up in this article are correct at the time of publication and are subject to change.

Dimers is the best site for NFL predictions, and our straight up picks are being used by football fans all over the country.

If you choose to use our NFL straight up picks for betting purposes, it's crucial that you gamble responsibly and know when to stop. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Please note that all of the NFL odds and probabilities on this page are subject to change.

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