NFL Picks Straight Up: Week 10, 2023

Dimers.com provides weekly NFL picks straight up as part of our NFL Picks coverage.

Week 10 of the NFL season is here, and we've used our state-of-the-art predictive analytics model to provide you with straight up NFL picks for all 14 games.

Gain the edge in NFL pick 'em competitions via our data-driven NFL picks for Week 10 of the 2023 NFL season. These picks are based on over 10,000 simulations of each NFL game.

There are 14 games scheduled for Week 10 of the 2023 NFL season, starting with the Carolina Panthers playing the Chicago Bears on Thursday night and concluding with the Denver Broncos facing the Buffalo Bills on Monday.

These straight up picks for Week 10 are sponsored by Bet365, which has a Bet $5, Get $150 in Bonus Bets promo for new users.

Simply bet $5 on any of the NFL picks below to get $150 in bonus bets to use on the rest of the Week 10 NFL slate!

See below for a full breakdown of each team's chances of winning in NFL Week 10.

Straight Up NFL Picks - Week 10

Here are our Week 10 NFL predictions, which show how likely it is that each NFL team will win its game this week.

Carolina Panthers vs. Chicago Bears

The Panthers face the Bears at Soldier Field on Thursday to start Week 10. According to our NFL model, the Bears have a 64% chance of winning, while the Panthers have a 36% chance.

Carolina Panthers vs. Chicago Bears is at Soldier Field on Thursday, November 9 at 8:15pm EST.

All times stated in this article are in Eastern Standard Time (EST).

Indianapolis Colts vs. New England Patriots

In this week's game between the Colts and the Patriots, Indianapolis is more likely to win. Our prediction model gives the Colts a 58% chance of winning. On the other hand, there is a 42% chance that the Patriots will win.

Indianapolis Colts vs. New England Patriots is at Deutsche Bank Park on Sunday, November 12 at 9:30am.

MORE: Super Bowl Odds

Green Bay Packers vs. Pittsburgh Steelers

We are picking the Steelers to win their game against the Packers this week, with our trusted NFL model projecting a 63% win probability for the home team. The Packers have a 37% chance of winning at Acrisure Stadium.

If you're looking to bet on this clash, Bet365 has the Steelers listed as -3 favorites, whilst the Packers' moneyline odds are at +140.

Green Bay Packers vs. Pittsburgh Steelers is at Acrisure Stadium on Sunday, November 12 at 1:00pm.

New Orleans Saints vs. Minnesota Vikings

According to our predictive analytics model, the Saints are the team to beat in this game, with their win probability at 62%. The Vikings, on the other hand, have a 38% chance of winning.

New Orleans Saints vs. Minnesota Vikings is at U.S. Bank Stadium on Sunday, November 12 at 1:00pm.

MORE: NFL Best Bets

Houston Texans vs. Cincinnati Bengals

The Bengals have a 76% chance of winning on Sunday afternoon, compared to the Texans' 24% chance of victory. This makes the Cincinnati Bengals our pick to win at Paycor Stadium.

Houston Texans vs. Cincinnati Bengals is at Paycor Stadium on Sunday, November 12 at 1:00pm.

Cleveland Browns vs. Baltimore Ravens

The Ravens are favored to win this game, with our model giving them a 75% chance, while the Browns enter the weekend with a 25% chance of causing an upset at M&T Bank Stadium.

When it comes to betting on this game, Bet365 has the Browns' moneyline odds set at +210, with the home team Ravens listed as -6 favorites.

Cleveland Browns vs. Baltimore Ravens is at M&T Bank Stadium on Sunday, November 12 at 1:00pm.

Tennessee Titans vs. Tampa Bay Buccaneers

After 10,000 simulations of Titans vs. Buccaneers this Sunday, our model projects the Buccaneers as the more likely winners with a probability of 51%. Their opponents the Titans have a 49% chance of getting the win on the road.

Tennessee Titans vs. Tampa Bay Buccaneers is at Raymond James Stadium on Tennessee, November 12 at 1:00pm.

MORE: NFL Player Props

San Francisco 49ers vs. Jacksonville Jaguars

DimersBOT is picking the 49ers in this game, with the 49ers given a 57% chance of winning, while the Jaguars have a 43% win probability.

San Francisco 49ers vs. Jacksonville Jaguars is at EverBank Stadium on Sunday, November 12 at 1:00pm.

Detroit Lions vs. Los Angeles Chargers

The next game of Week 10 sees the Lions take on the Chargers at SoFi Stadium.

We are predicting the Lions to win with projected win chance of 59%, while the Chargers are projected to have a win chance of 41%.

As for the Vegas betting odds here, Bet365 has the Chargers listed as +1.5 underdogs, with the Lions' moneyline odds posted at -120.

Detroit Lions vs. Los Angeles Chargers is at SoFi Stadium on Sunday, November 12 at 4:05pm.

Atlanta Falcons vs. Arizona Cardinals

The likely winner of this matchup is the Falcons who have a projected win chance of 52% according to DimersBOT. On the other side of this matchup, the Cardinals have a projected win probability of 48%.

Atlanta Falcons vs. Arizona Cardinals is at State Farm Stadium on Sunday, November 12 at 4:05pm.

MORE: Best NFL Bets Today

Washington Commanders vs. Seattle Seahawks

We have run our powerful NFL model over this week’s Commanders-Seahawks clash 10,000 times, with the Seahawks coming out as the team to pick. Of those 10,000 simulations, the Seahawks won 7,238 times, with the Commanders winning on 2,762 occasions.

Washington Commanders vs. Seattle Seahawks is at Lumen Field on Sunday, November 12 at 4:25pm.

New York Giants vs. Dallas Cowboys

Next up is the game between the Giants and Cowboys, with our model projecting the home team as the more likely victor, with Cowboys rated as a 95% chance of getting the W. The Giants on the other hand are projected to have a 5% chance of winning.

For those interested in betting on this matchup, Bet365 has the Giants' moneyline odds set at +900 for this road game, whilst the hosting Cowboys are listed as -16.5 favorites.

New York Giants vs. Dallas Cowboys is at AT&T Stadium on Sunday, November 12 at 4:25pm.

New York Jets vs. Las Vegas Raiders

Our next straight up pick this week is for the Jets to get the win against the Raiders. After running 10,000 simulations of this matchup, the NY Jets have a win probability of 63%, with the Raiders at 37%.

New York Jets vs. Las Vegas Raiders is at Allegiant Stadium on Sunday, November 12 at 8:20pm.

Denver Broncos vs. Buffalo Bills

With a win probability of 76% on Monday night, our straight up pick for this match is the Bills, while their opponent, the Broncos, have a projected win chance of 24%.

Denver Broncos vs. Buffalo Bills is at Highmark Stadium on Monday, November 13 at 8:15pm.

MORE: NFL Player Prop Picks for Week 10

NFL Picks This Week Straight Up [Week 10, 2023]

• Bears (64% win probability)
• Colts (58%)
• Steelers (63%)
• Saints (62%)
• Bengals (76%)
• Ravens (75%)
• Buccaneers (51%)
• 49ers (57%)
• Lions (59%)
• Falcons (52%)
• Seahawks (72%)
• Cowboys (95%)
• Jets (63%)
• Bills (76%)

NFL Week 10 Slate and Game Times

• Panthers vs. Bears (Thursday, 8:15PM ET)
• Colts vs. Patriots (Sunday, 9:30AM ET)
• Packers vs. Steelers (Sunday, 1:00PM ET)
• Saints vs. Vikings (Sunday, 1:00PM ET)
• Texans vs. Bengals (Sunday, 1:00PM ET)
• Browns vs. Ravens (Sunday, 1:00PM ET)
• Titans vs. Buccaneers (Sunday, 1:00PM ET)
• 49ers vs. Jaguars (Sunday, 1:00PM ET)
• Lions vs. Chargers (Sunday, 4:05PM ET)
• Falcons vs. Cardinals (Sunday, 4:05PM ET)
• Commanders vs. Seahawks (Sunday, 4:25PM ET)
• Giants vs. Cowboys (Sunday, 4:25PM ET)
• Jets vs. Raiders (Sunday, 8:20PM ET)
• Broncos vs. Bills (Monday, 8:15PM ET)

All times mentioned in this article are in Eastern Standard Time (EST).

NFL Week 10 Bye Teams: Who Has a Bye This Week?

The Kansas City Chiefs, Los Angeles Rams, Miami Dolphins and Philadelphia Eagles are on byes in Week 10.

NFL Straight Up Picks and Predictions - Week 10

The NFL Week 10 picks straight up in this article are correct at the time of publication and are subject to change.

Dimers is the best site for NFL predictions, and our straight up picks are being used by football fans all over the country.

If you decide to use our NFL straight up picks for betting purposes, it's important that you gamble responsibly and know when to stop. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Please note that all of the odds and probabilities on this page are subject to change.

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