NFL Picks and Predictions Straight Up: Week 6, 2024

At Dimers.com, we provide NFL picks straight up for Week 6 and beyond, as part of our in-depth NFL picks and NFL predictions coverage.

With Week 6 of the NFL season here, we've used our cutting-edge predictive analytics model to deliver NFL straight up picks for all 14 games this week.

Gain the edge in your NFL pick 'em contests with our data-driven NFL Week 6 picks straight up, powered by thousands of game simulations.

Week 6 of the NFL season features 14 games, starting with the San Francisco 49ers facing the Seattle Seahawks on Thursday night and concluding with the Buffalo Bills taking on the New York Jets on Monday.

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For more NFL betting coverage, check out the best NFL week 6 odds and our NFL picks against the spread for Week 6.

NFL Picks This Week Straight Up: Week 6, 2024

Here are our Week 6 NFL picks, highlighting how likely each team is to win their game this week.

San Francisco 49ers vs. Seattle Seahawks

The 49ers kick off Week 6 against the Seahawks at Lumen Field on Thursday night. According to our model, the 49ers have a 60% chance of winning, while the Seahawks have a 40% chance.

For Week 6's opening game, our model highlights NFL player props with Jordan Mason (RB) as the most likely player from the 49ers to score the first TD at 15.2%, while Kenneth Walker (RB) is the top candidate from the Seahawks at 10.8%.

The San Francisco 49ers vs. Seattle Seahawks game at Lumen Field is scheduled for Thursday, October 10 at 8:15pm. All times mentioned in this article are in Eastern Standard Time (EST).

Jacksonville Jaguars vs. Chicago Bears

For this week's game between the Jaguars and the Bears, Chicago is more likely to win. Our prediction model gives the Bears a 57% chance of winning. On the other hand, there is a 43% chance that the Jaguars will win.

The Jacksonville Jaguars vs. Chicago Bears matchup at Tottenham Hotspur Stadium will take place on Sunday, October 13 at 9:30am.

As the regular season approaches its conclusion, track the top teams with our updated NFL futures, highlighting top Super Bowl contenders.

Tampa Bay Buccaneers vs. New Orleans Saints

We are picking the Buccaneers to win their game against the Saints this week, with our trusted NFL model projecting a 62% win probability for the road team. The Saints have a 38% chance of winning at Caesars Superdome.

For betting purposes, the Saints are listed as +3.5 underdogs, with the Buccaneers' moneyline at -170.

The Tampa Bay Buccaneers vs. New Orleans Saints game at Caesars Superdome is slated for Sunday, October 13 at 1:00pm.

Arizona Cardinals vs. Green Bay Packers

According to our predictive analytics model, the Packers are the team to beat in this game, with their win probability at 68%. The Cardinals, on the other hand, have a 32% chance of winning.

The Arizona Cardinals vs. Green Bay Packers game at Lambeau Field is set for Sunday, October 13 at 1:00pm.

Indianapolis Colts vs. Tennessee Titans

The Titans have a 58% chance of winning on Sunday afternoon, compared to the Colts' 42% chance of victory. This makes the Tennessee Titans our pick to win at Nissan Stadium.

The Indianapolis Colts vs. Tennessee Titans matchup at Nissan Stadium is scheduled for Sunday, October 13 at 1:00pm.

Cleveland Browns vs. Philadelphia Eagles

The Eagles are favorites to win here, with our predictive analytics model giving them an 80% chance, while the Browns enter the weekend with a 20% chance of causing an upset at Lincoln Financial Field.

When it comes to betting on this game, the Browns' moneyline odds are set at +410, with the home team Eagles listed as -9.5 favorites.

The Cleveland Browns vs. Philadelphia Eagles game at Lincoln Financial Field will take place on Sunday, October 13 at 1:00pm.

Houston Texans vs. New England Patriots

After 10,000 simulations of Texans vs. Patriots this Sunday, our model projects the Texans as the more likely winners with a probability of 79%. Their opponents, the Patriots, have a 21% chance of getting the win at home.

The Houston Texans vs. New England Patriots matchup at Gillette Stadium is slated for Sunday, October 13 at 1:00pm.

Washington Commanders vs. Baltimore Ravens

DimersBOT is picking the Ravens, who have a 70% chance of winning the matchup, while the Commanders have a 30% chance of an upset win.

The Washington Commanders vs. Baltimore Ravens game at M&T Bank Stadium will take place on Sunday, October 13 at 1:00pm.

Los Angeles Chargers vs. Denver Broncos

The next game of Week 6 sees the Chargers take on the Broncos at Empower Field at Mile High.

We predict the Chargers to win with a probability of 64%, while the Broncos are projected to have a win chance of 36%.

As for the Vegas betting odds here, the Broncos are listed as +3 underdogs, with the Chargers' moneyline odds posted at -148.

The Los Angeles Chargers vs. Denver Broncos game at Empower Field at Mile High is scheduled for Sunday, October 13 at 4:05pm.

Pittsburgh Steelers vs. Las Vegas Raiders

The likely winner of this matchup is the Steelers, who have a projected win chance of 64%, according to DimersBOT. On the other side of this matchup, the Raiders have a projected win probability of 36%.

The Pittsburgh Steelers vs. Las Vegas Raiders matchup at Allegiant Stadium is set for Sunday, October 13 at 4:05pm.

Atlanta Falcons vs. Carolina Panthers

We have run our powerful NFL model over this week’s Falcons-Panthers clash 10,000 times, with the Falcons coming out as the team to pick. Of those 10,000 simulations, the Falcons won 7,009 times, with the Panthers winning on 2,991 occasions.

The Atlanta Falcons vs. Carolina Panthers game at Bank of America Stadium is scheduled for Sunday, October 13 at 4:25pm.

Detroit Lions vs. Dallas Cowboys

Next up is the game between the Lions and Cowboys, with our model projecting the road team as the more likely victor, with the Lions rated as having a 60% chance of getting the W. The Cowboys, on the other hand, are projected to have a 40% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Lions' moneyline odds set at -155 for this road game, while the hosting Cowboys are listed as +3 underdogs.

The Detroit Lions vs. Dallas Cowboys game at AT&T Stadium will take place on Sunday, October 13 at 4:25pm.

Cincinnati Bengals vs. New York Giants

Our next straight up pick this week is for the Bengals to get the win against the Giants. After running 10,000 simulations of this matchup, the Cincinnati have a win probability of 63%, with the Giants at 37%.

The Cincinnati Bengals vs. New York Giants game at MetLife Stadium is slated for Sunday, October 13 at 8:20pm.

Buffalo Bills vs. New York Jets

With a win probability of 59% on Monday night, our straight up pick for this game is the Bills, while their opponent, the Jets, have a projected win chance of 41%.

The Buffalo Bills vs. New York Jets game at MetLife Stadium will take place on Monday, October 14 at 8:15pm.

For a different angle on this week's NFL action, explore Dimers' NFL trends to spot the latest player prop trends.

NFL Week 6 Picks Straight Up:

• 49ers (60% win probability)
• Bears (57%)
• Buccaneers (62%)
• Packers (68%)
• Titans (58%)
• Eagles (80%)
• Texans (79%)
• Ravens (70%)
• Chargers (64%)
• Steelers (64%)
• Falcons (70%)
• Lions (60%)
• Bengals (63%)
• Bills (59%)

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NFL Straight Up Picks and Predictions for Week 6

The NFL Week 6 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.

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