NFL Picks and Predictions Straight Up: Week 4, 2024

At Dimers.com, we provide NFL picks straight up for Week 4 and every week, as part of our extensive NFL picks and NFL predictionscoverage.

With Week 4 of the NFL season upon us, we've harnessed our dynamic predictive analytics model to deliver NFL straight up picks for all 16 games this week.

Gain the edge in your NFL pick 'em contests with our data-driven NFL Week 4 picks straight up, powered by thousands of game simulations.

Week 4 of the NFL season features 16 games, starting with the Dallas Cowboys facing the New York Giants on Thursday night and wrapping up with the Seattle Seahawks taking on the Detroit Lions on Monday night.

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For more NFL betting coverage, check out the best NFL week 4 odds for a breakdown on the moneyline, spread and total for every game this week.

NFL Picks This Week Straight Up: Week 4, 2024

Here are our Week 4 NFL picks, highlighting each team's chances of winning their game this week.

Dallas Cowboys vs. New York Giants

The Cowboys kick off Week 4 against the Giants at MetLife Stadium on Thursday. According to our model, the Cowboys have a 69% chance of winning, while the Giants have a 31% chance.

For Week 4's opening game, our model highlights NFL player props with CeeDee Lamb (WR) as the most likely player from the Cowboys to score the first TD at 12.8%, while Malik Nabers(WR) is the top candidate from the Giants at 9.2%.

The Dallas Cowboys vs. New York Giants game at MetLife Stadium is scheduled for Thursday, September 26 at 8:15pm. All times mentioned in this article are in Eastern Standard Time (EST).

Pittsburgh Steelers vs. Indianapolis Colts

For this week's game between the Steelers and the Colts, Pittsburgh is more likely to win. Our prediction model gives the Steelers a 59% chance of winning. On the other hand, there is a 41% chance that the Colts will win.

The Pittsburgh Steelers vs. Indianapolis Colts matchup at Lucas Oil Stadium will take place on Sunday, September 29 at 1:00pm.

As the season heats up, track the top teams with our updated NFL futures, highlighting top Super Bowl contenders.

Minnesota Vikings vs. Green Bay Packers

We are picking the Packers to win their game against the Vikings this week, with our trusted NFL model projecting a 58% win probability for the home team. The Vikings have a 42% chance of winning.

For betting purposes, the Packers are listed as -2.5 favorites, with the Vikings' moneyline at +122.

The Minnesota Vikings vs. Green Bay Packers game at Lambeau Field is slated for Sunday, September 29 at 1:00pm.

Jacksonville Jaguars vs. Houston Texans

According to our predictive analytics model, the Texans are the team to beat in this game, with their win probability at 73%. The Jaguars, on the other hand, have a 27% chance of winning.

The Jacksonville Jaguars vs. Houston Texans game at NRG Stadium is set for Sunday, September 29 at 1:00pm.

New Orleans Saints vs. Atlanta Falcons

The Falcons have a 56% chance of winning on Sunday afternoon, compared to the Saints' 44% chance of victory. This makes the Atlanta Falcons our pick to win at Mercedes-Benz Stadium.

The New Orleans Saints vs. Atlanta Falcons matchup at Mercedes-Benz Stadium is scheduled for Sunday, September 29 at 1:00pm.

Los Angeles Rams vs. Chicago Bears

The Bears are favored to win here, with our model giving them a 60% chance, while the Rams enter the weekend with a 40% chance of winning at Soldier Field.

When it comes to betting on this game, the Rams' moneyline odds are set at +132, with the home team Bears listed as -2 favorites.

The Los Angeles Rams vs. Chicago Bears game at Soldier Field will take place on Sunday, September 29 at 1:00pm.

Philadelphia Eagles vs. Tampa Bay Buccaneers

After 10,000 simulations of Eagles vs. Buccaneers this Sunday, our model projects the Eagles as the more likely winners with a probability of 57%. Their opponents, the Buccaneers, have a 43% chance of getting the win at home.

The Philadelphia Eagles vs. Tampa Bay Buccaneers matchup at Raymond James Stadium is slated for Sunday, September 29 at 1:00pm.

Cincinnati Bengals vs. Carolina Panthers

Our model is picking the Bengals, who have a 65% chance of winning the matchup, while the Panthers have a 35% chance of an upset win.

The Cincinnati Bengals vs. Carolina Panthers game at Bank of America Stadium will take place on Sunday, September 29 at 1:00pm.

Denver Broncos vs. New York Jets

The next game of Week 4 sees the Broncos take on the Jets at MetLife Stadium.

We predict the Jets to win with a probability of 78%, while the Broncos are projected to have a win chance of 22%.

As for the Vegas betting odds here, the Jets are listed as -7.5 favorites, with the Broncos' moneyline odds posted at +295.

The Denver Broncos vs. New York Jets game at MetLife Stadium is scheduled for Sunday, September 29 at 1:00pm.

Washington Commanders vs. Arizona Cardinals

The likely winner of this matchup is the Cardinals, who have a projected win chance of 61%, according to DimersBOT. On the other side of this matchup, the Commanders have a projected win probability of 39%.

The Washington Commanders vs. Arizona Cardinals matchup at State Farm Stadium is set for Sunday, September 29 at 4:05pm.

New England Patriots vs. San Francisco 49ers

We have run our powerful NFL model over this week’s Patriots-49ers clash 10,000 times, with the 49ers coming out as the team to pick. Of those 10,000 simulations, the 49ers won 8,337 times, with the Patriots winning on 1,663 occasions.

The New England Patriots vs. San Francisco 49ers game at Levi's Stadium is scheduled for Sunday, September 29 at 4:05pm.

Cleveland Browns vs. Las Vegas Raiders

Next up is the game between the Browns and Raiders, with our model projecting the home team as the more likely victor, with the Raiders rated as having a 55% chance of getting the W. The Browns, on the other hand, are projected to have a 45% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Browns' moneyline odds set at -105 for this road game, while the hosting Raiders are listed as +1.5 underdogs.

The Cleveland Browns vs. Las Vegas Raiders game at Allegiant Stadium will take place on Sunday, September 29 at 4:25pm.

Kansas City Chiefs vs. Los Angeles Chargers

Our next straight up pick this week is for the Chiefs to get the win against the Chargers. After running 10,000 simulations of this matchup, the Kansas City have a win probability of 79%, with the Chargers at 21%.

The Kansas City Chiefs vs. Los Angeles Chargers game at SoFi Stadium is slated for Sunday, September 29 at 4:25pm.

Buffalo Bills vs. Baltimore Ravens

With a win probability of 59% on Sunday night, our straight up pick for this matchup is the Ravens, while their opponent, the Bills, have a projected win chance of 41%.

The Buffalo Bills vs. Baltimore Ravens game at M&T Bank Stadium will take place on Sunday, September 29 at 8:20pm.

For a different angle on this week's NFL action, explore Dimers' NFL trends to spot the latest player prop trends.

Tennessee Titans vs. Miami Dolphins

The team to pick here is the Dolphins, who have a 52% chance of winning their matchup against the Titans this Sunday night.

Looking at the betting odds for this Monday Night Football clash, the Dolphins are listed as -1 favorites at home, with the Titans' moneyline odds available at -108.

The Tennessee Titans vs. Miami Dolphins game at Hard Rock Stadium is scheduled for Monday, September 30 at 7:30pm.

Seattle Seahawks vs. Detroit Lions

Our pick to win the final game of Week 4 is the Lions, who have a win probability of 62%. Their opponents are projected to have a 38% chance of getting the W.

The Seattle Seahawks vs. Detroit Lions game at Ford Field is set for Monday, September 30 at 8:15pm.

NFL Week 4 Picks Straight Up:

• Cowboys (69% win probability)
• Steelers (59%)
• Packers (58%)
• Texans (73%)
• Falcons (56%)
• Bears (60%)
• Eagles (57%)
• Bengals (65%)
• Jets (78%)
• Cardinals (61%)
• 49ers (83%)
• Raiders (55%)
• Chiefs (79%)
• Ravens (59%)
• Dolphins (52%)
• Lions (62%)

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NFL Straight Up Picks and Predictions for Week 4

The NFL Week 4 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.

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