NFL Picks and Predictions Straight Up: Week 2, 2024

At Dimers.com, we offer NFL picks straight up for Week 2 and every week, as part of our in-depth NFL picks and NFL predictions coverage.

With Week 2 of the NFL season here, we've used our cutting-edge predictive analytics model to deliver NFL straight up picks for all 16 games this week.

Gain the edge in your NFL pick 'em contests via our data-driven NFL Week 2 picks straight up, powered by thousands of game simulations.

Week 2 of the NFL season features 16 games, starting with the Buffalo Bills facing the Miami Dolphins on Thursday night and ending with the Atlanta Falcons taking on the Philadelphia Eagles on Monday night.

Before placing any NFL wagers this week, be sure to explore our full list of NFL best bets with Dimers Pro.

Our data-driven approach ensures you have the tools you need for every NFL game, every week. Subscribe now and start betting smarter.

For more NFL betting coverage, check out the best NFL week 2 odds and our NFL picks against the spread for Week 2.

NFL Picks This Week Straight Up: Week 2, 2024

Here are our Week 2 NFL picks, highlighting each team's chances of winning their game this week.

Buffalo Bills vs. Miami Dolphins

The Bills kick off Week 2 against the Dolphins at Hard Rock Stadium on Thursday night. According to our model, the Dolphins have a 59% chance of winning, while the Bills have a 41% chance.

For Week 2's opening game, our model highlights NFL player props with Josh Allen (QB) as the most likely player from the Bills to score the first TD at 10.1%, while Tyreek Hill (WR) is the top candidate from the Dolphins at 12.3%.

The Buffalo Bills vs. Miami Dolphins game at Hard Rock Stadium is scheduled for Thursday, September 12 at 8:15pm. All times mentioned in this article are in Eastern Standard Time (EST).

New Orleans Saints vs. Dallas Cowboys

For this week's game between the Saints and the Cowboys, Dallas is more likely to win. Our prediction model gives the Cowboys a 70% chance of winning. On the other hand, there is a 30% chance that the Saints will pull off an upset win.

The New Orleans Saints vs. Dallas Cowboys matchup at AT&T Stadium will take place on Sunday, September 15 at 1:00pm.

As the season heats up, track the top teams with our updated NFL futures, highlighting top Super Bowl contenders.

Las Vegas Raiders vs. Baltimore Ravens

We are picking the Ravens to win their game against the Raiders this week, with our trusted NFL model projecting a 79% win probability for the home team. The Raiders have a 21% chance of winning.

For betting purposes, the Ravens are listed as -8.5 favorites, with the Raiders' moneyline at +370.

The Las Vegas Raiders vs. Baltimore Ravens game at M&T Bank Stadium is slated for Sunday, September 15 at 1:00pm.

New York Giants vs. Washington Commanders

According to our predictive analytics model, the Commanders are the team to beat in this game, with their win probability at 58%. The Giants, on the other hand, have a 42% chance of winning.

The New York Giants vs. Washington Commanders game at Northwest Stadium is set for Sunday, September 15 at 1:00pm.

Los Angeles Chargers vs. Carolina Panthers

The Chargers have a 72% chance of winning on Sunday afternoon, compared to the Panthers' 28% chance of victory. This makes the LA Chargers Chargers our pick to win at Bank of America Stadium.

The Los Angeles Chargers vs. Carolina Panthers matchup at Bank of America Stadium is scheduled for Sunday, September 15 at 1:00pm.

Indianapolis Colts vs. Green Bay Packers

The Colts are favored to win their Week 2 matchup, with our predictive analytics model giving them a 56% chance, while the Packers enter the weekend with a 44% chance of winning at Lambeau Field.

When it comes to betting on this game, the Colts' moneyline odds are set at -142, with the home team Packers listed as +2.5 underdogs.

The Indianapolis Colts vs. Green Bay Packers game at Lambeau Field will take place on Sunday, September 15 at 1:00pm.

San Francisco 49ers vs. Minnesota Vikings

After 10,000 simulations of 49ers vs. Vikings this Sunday, our model projects the 49ers as the more likely winners with a probability of 65%. Their opponents, the Vikings, have a 35% chance of getting the win at home.

The San Francisco 49ers vs. Minnesota Vikings matchup at U.S. Bank Stadium is slated for Sunday, September 15 at 1:00pm.

Cleveland Browns vs. Jacksonville Jaguars

Our model is picking the Jaguars, who have a 60% chance of winning the matchup, while the Browns have a 40% win probability.

The Cleveland Browns vs. Jacksonville Jaguars game at EverBank Stadium will take place on Sunday, September 15 at 1:00pm.

Seattle Seahawks vs. New England Patriots

The next game of Week 2 sees the Seahawks take on the Patriots at Gillette Stadium.

We predict the Seahawks to win with a probability of 66%, while the Patriots are projected to have a win chance of 34%.

As for the Vegas betting odds here, the Patriots are listed as +3.5 underdogs, with the Seahawks' moneyline odds posted at -185.

The Seattle Seahawks vs. New England Patriots game at Gillette Stadium is scheduled for Sunday, September 15 at 1:00pm.

New York Jets vs. Tennessee Titans

The likely winner of this matchup is the Jets, who have a projected win chance of 64%, according to DimersBOT. On the other side of this matchup, the Titans have a projected win probability of 36%.

The New York Jets vs. Tennessee Titans matchup at Nissan Stadium is set for Sunday, September 15 at 1:00pm.

Tampa Bay Buccaneers vs. Detroit Lions

We have run our powerful NFL model over this week’s Buccaneers-Lions clash 10,000 times, with the Lions coming out as the team to pick. Of those 10,000 simulations, the Lions won 7,299 times, with the Buccaneers winning on 2,701 occasions.

The Tampa Bay Buccaneers vs. Detroit Lions game at Ford Field is scheduled for Sunday, September 15 at 1:00pm.

Los Angeles Rams vs. Arizona Cardinals

Next up is the game between the Rams and Cardinals, with our model projecting the home team as the more likely victor, with the Cardinals rated as having a 54% chance of getting the W. The Rams, on the other hand, are projected to have a 46% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Rams' moneyline odds set at +104 for this road game, while the hosting Cardinals are listed as -1.5 favorites.

The Los Angeles Rams vs. Arizona Cardinals game at State Farm Stadium will take place on Sunday, September 15 at 4:05pm.

Pittsburgh Steelers vs. Denver Broncos

Our next straight up pick this week is for the Steelers to get the win against the Broncos. After running 10,000 simulations of this matchup, the Pittsburgh have a win probability of 60%, with the Broncos at 40%.

The Pittsburgh Steelers vs. Denver Broncos game at Empower Field at Mile High is slated for Sunday, September 15 at 4:25pm.

Cincinnati Bengals vs. Kansas City Chiefs

With a win probability of 68% on Sunday afternoon, our straight up pick for this matchup is the Chiefs, while their opponent, the Bengals, have a projected win chance of 32%.

The Cincinnati Bengals vs. Kansas City Chiefs game at GEHA Field at Arrowhead Stadium will take place on Sunday, September 15 at 4:25pm.

For a different angle on this week's NFL action, explore Dimers' NFL trends to spot the latest player prop trends.

Chicago Bears vs. Houston Texans

The team to pick here is the Texans, who have a 73% chance of winning their matchup against the Bears this Sunday night.

Looking at the betting odds for this Sunday Night Football clash, the Texans are listed as -6.5 favorites at home, with the Bears' moneyline odds available at +240.

The Chicago Bears vs. Houston Texans game at NRG Stadium is scheduled for Sunday, September 15 at 8:20pm.

Atlanta Falcons vs. Philadelphia Eagles

Our pick to win the final game of Week 2 is the Eagles, who have a win probability of 72%. Their opponents are projected to have a 28% chance of getting the W.

The Atlanta Falcons vs. Philadelphia Eagles game at Lincoln Financial Field is set for Monday, September 16 at 8:15pm.

NFL Week 2 Picks Straight Up:

• Dolphins (59% win probability)
• Cowboys (70%)
• Ravens (79%)
• Commanders (58%)
• Chargers (72%)
• Colts (56%)
• 49ers (65%)
• Jaguars (60%)
• Seahawks (66%)
• Jets (64%)
• Lions (73%)
• Cardinals (54%)
• Steelers (60%)
• Chiefs (68%)
• Texans (73%)
• Eagles (72%)

NFL Fantasy and Betting Promotions

Make the most of Dimers' NFL straight up picks and predictions this week by exploring the two exciting offers below.

DraftKings Pick6

Sign up for DraftKings Pick6 today! Play $5 and get $50 in Pick6 Credits, plus one month of NFL RedZone access.

FanDuel Sportsbook

Get ready for NFL Week 2 by joining FanDuel Sportsbook! Bet $5 and get $200 in bonus bets, plus 3 weeks of NFL Sunday Ticket.

NFL Straight Up Picks and Predictions for Week 2

The NFL Week 2 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

If you decide to use our NFL straight up picks for betting, it's crucial to gamble responsibly and know when to stop. For more resources and advice on responsible gambling, please call 1-800-GAMBLER.

Please note that all NFL odds and probabilities mentioned on this page are subject to change.

More on the NFL

In addition to being your best source for NFL pick'em predictions, we also offer the latest NFL news and NFL parlay picks.