NFL Picks and Predictions Straight Up: Week 18, 2025

At Dimers.com, we offer NFL picks straight up for Week 18 and beyond, as part of our extensive NFL picks and NFL predictions coverage.

With Week 18 of the NFL season upon us, we've harnessed our state-of-the-art predictive analytics model to deliver a list of NFL straight up picks for all 16 games this week.

Get an advantage in your NFL pick 'em competitions via our data-driven NFL Week 18 picks straight up, powered by thousands of game simulations.

Week 18 of the NFL season features 16 games, beginning with the Cleveland Browns facing the Baltimore Ravens on Saturday and concluding with the Minnesota Vikings taking on the Detroit Lions on Sunday night.

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For more NFL betting coverage, check out the best NFL week 18 odds and our NFL picks against the spread for Week 18.

NFL Picks This Week Straight Up: Week 18, 2025

Listed below are our Week 18 NFL picks, highlighting how likely each team is to win their game this week.

Cleveland Browns vs. Baltimore Ravens

The Browns kick off Week 18 against the Ravens at M&T Bank Stadium on Saturday. According to our model, the Ravens have a 97% chance of winning, while the Browns have a 3% chance.

For Week 18's opening game, our model highlights NFL player props with D'Onta Foreman (RB) as the most likely player from the Browns to score the first TD at 9.2%, while Derrick Henry (RB) is the top candidate from the Ravens at 23.2%.

The Cleveland Browns vs. Baltimore Ravens game at M&T Bank Stadium is scheduled for Saturday, January 4 at 4:30pm. All times stated in this article are in Eastern Standard Time (EST).

Cincinnati Bengals vs. Pittsburgh Steelers

For this week's game between the Bengals and the Steelers, Cincinnati is more likely to win. Our prediction model gives the Bengals a 57% chance of winning. On the other hand, there is a 43% chance that the Steelers will win.

The Cincinnati Bengals vs. Pittsburgh Steelers matchup at Acrisure Stadium will take place on Saturday, January 4 at 8:00pm.

As the playoffs apporoach, track the top teams with our updated NFL futures, highlighting top Super Bowl contenders.

New York Giants vs. Philadelphia Eagles

We are picking the Eagles to win their game against the Giants this week, with our trusted NFL model projecting a 63% win probability for the home team. The Giants have a 37% chance of winning.

For betting purposes, the Eagles are listed as -3 favorites, with the Giants' moneyline at +130.

The New York Giants vs. Philadelphia Eagles game at Lincoln Financial Field is slated for Sunday, January 5 at 1:00pm.

Chicago Bears vs. Green Bay Packers

According to our predictive analytics model, the Packers are the team to beat in this game, with their win probability at 83%. The Bears, on the other hand, have a 17% chance of winning.

The Chicago Bears vs. Green Bay Packers game at Lambeau Field is set for Sunday, January 5 at 1:00pm.

Carolina Panthers vs. Atlanta Falcons

The Falcons have a 75% chance of winning on Sunday afternoon, compared to the Panthers' 25% chance of victory. This makes the Atlanta Falcons our pick to win at Mercedes-Benz Stadium.

The Carolina Panthers vs. Atlanta Falcons matchup at Mercedes-Benz Stadium is scheduled for Sunday, January 5 at 1:00pm.

New Orleans Saints vs. Tampa Bay Buccaneers

The Buccaneers are favorites to win their Week 18 matchup, with our predictive analytics model giving them a 90% chance, while the Saints enter the weekend with a 10% chance of causing an upset at Raymond James Stadium.

When it comes to betting on this game, the Saints' moneyline odds are set at +610, with the home team Buccaneers listed as -14 favorites.

The New Orleans Saints vs. Tampa Bay Buccaneers game at Raymond James Stadium will take place on Sunday, January 5 at 1:00pm.

Washington Commanders vs. Dallas Cowboys

After 10,000 simulations of Commanders vs. Cowboys this Sunday, our model projects the Commanders as the more likely winners with a probability of 71%. Their opponents, the Cowboys, have a 29% chance of getting the win at home.

The Washington Commanders vs. Dallas Cowboys matchup at AT&T Stadium is slated for Sunday, January 5 at 1:00pm.

Jacksonville Jaguars vs. Indianapolis Colts

Our model is picking the Colts, who have a 67% chance of winning the game, while the Jaguars have a 33% win probability.

The Jacksonville Jaguars vs. Indianapolis Colts game at Lucas Oil Stadium will take place on Sunday, January 5 at 1:00pm.

Houston Texans vs. Tennessee Titans

The next game of Week 18 sees the Texans take on the Titans at Nissan Stadium.

We predict the Titans to win with a probability of 56%, while the Texans are projected to have a win chance of 44%.

As for the Vegas betting odds here, the Titans are listed as -1.5 favorites, with the Texans' moneyline odds posted at +105.

The Houston Texans vs. Tennessee Titans game at Nissan Stadium is scheduled for Sunday, January 5 at 1:00pm.

Buffalo Bills vs. New England Patriots

The likely winner of this matchup is the Bills, who have a projected win chance of 60%, according to DimersBOT. On the other side of this matchup, the Patriots have a projected win probability of 40%.

The Buffalo Bills vs. New England Patriots matchup at Gillette Stadium is set for Sunday, January 5 at 1:00pm.

Kansas City Chiefs vs. Denver Broncos

We have run our powerful NFL model over this week’s Chiefs-Broncos clash 10,000 times, with the Broncos coming out as the team to pick. Of those 10,000 simulations, the Broncos won 8,461 times, with the Chiefs winning on 1,539 occasions.

The Kansas City Chiefs vs. Denver Broncos game at Empower Field at Mile High is scheduled for Sunday, January 5 at 4:25pm.

San Francisco 49ers vs. Arizona Cardinals

Next up is the game between the 49ers and Cardinals, with our model projecting the home team as the more likely victor, with the Cardinals rated as having a 66% chance of getting the W. The 49ers, on the other hand, are projected to have a 34% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the 49ers' moneyline odds set at +180 for this road game, while the hosting Cardinals are listed as -4.5 favorites.

The San Francisco 49ers vs. Arizona Cardinals game at State Farm Stadium will take place on Sunday, January 5 at 4:25pm.

Miami Dolphins vs. New York Jets

Our next straight up pick this week is for the Dolphins to get the win against the Jets. After running 10,000 simulations of this matchup, the Miami have a win probability of 52%, with the Jets at 48%.

The Miami Dolphins vs. New York Jets game at MetLife Stadium is slated for Sunday, January 5 at 4:25pm.

Seattle Seahawks vs. Los Angeles Rams

With a win probability of 73% on Sunday afternoon, our straight up pick for this game is the Seahawks, while their opponent, the Rams, have a projected win chance of 27%.

The Seattle Seahawks vs. Los Angeles Rams game at SoFi Stadium will take place on Sunday, January 5 at 4:25pm.

For a different angle on this week's NFL action, explore Dimers' NFL trends to find the latest player prop trends.

Los Angeles Chargers vs. Las Vegas Raiders

The team to pick here is the Chargers, who have a 68% chance of winning their matchup against the Raiders this Sunday afternoon.

Looking at the betting odds for this Sunday afternoon clash, the Raiders are listed as +4.5 underdogs at home, with the Chargers' moneyline odds available at -192.

The Los Angeles Chargers vs. Las Vegas Raiders game at Allegiant Stadium is scheduled for Sunday, January 5 at 4:25pm.

Minnesota Vikings vs. Detroit Lions

Our pick to win the final game of Week 18 is the Lions, who have a win probability of 58%. Their opponents are projected to have a 42% chance of getting the W.

The Minnesota Vikings vs. Detroit Lions game at Ford Field is set for Sunday, January 5 at 8:20pm.

Full List of NFL Week 18 Picks Straight Up:

• Ravens (97% win probability)
• Bengals (57%)
• Eagles (63%)
• Packers (83%)
• Falcons (75%)
• Buccaneers (90%)
• Commanders (71%)
• Colts (67%)
• Titans (56%)
• Bills (60%)
• Broncos (85%)
• Cardinals (66%)
• Dolphins (52%)
• Seahawks (73%)
• Chargers (68%)
• Lions (58%)

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NFL Straight Up Picks and Predictions for Week 18

The NFL Week 18 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.

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