NFL Picks and Predictions Straight Up: Week 16, 2024

At Dimers.com, we provide NFL picks straight up for Week 16 and every week, as part of our extensive NFL picks and NFL predictions coverage.

With Week 16 of the NFL season upon us, we've harnessed our cutting-edge predictive analytics model to deliver a list of NFL straight up picks for all 16 games this week.

Secure an advantage in your NFL pick 'em competitions by following our data-driven NFL Week 16 picks straight up, powered by thousands of game simulations.

Week 16 of the NFL season features 16 games, starting with the Denver Broncos facing the Los Angeles Chargers on Thursday night and ending with the New Orleans Saints taking on the Green Bay Packers on Monday night.

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For more NFL betting coverage, check out the best NFL week 16 odds and our NFL picks against the spread for Week 16.

NFL Picks This Week Straight Up: Week 16, 2024

Here are our Week 16 NFL picks, highlighting each team's chances of winning their game this week.

Denver Broncos vs. Los Angeles Chargers

The Broncos kick off Week 16 against the Chargers at SoFi Stadium on Thursday. According to our model, the Chargers have a 59% chance of winning, while the Broncos have a 41% chance.

For Week 16's opening game, our model highlights NFL player props with Courtland Sutton (WR) as the most likely player from the Broncos to score the first TD at 14.1%, while Ladd McConkey (WR) is the top candidate from the Chargers at 6.7%.

The Denver Broncos vs. Los Angeles Chargers game at SoFi Stadium is scheduled for Thursday, December 19 at 8:15pm. All times stated in this article are in Eastern Standard Time (EST).

Houston Texans vs. Kansas City Chiefs

For this week's game between the Texans and the Chiefs, Kansas City is more likely to win. Our prediction model gives the Chiefs a 63% chance of winning. On the other hand, there is a 37% chance that the Texans will pull off an upset win.

The Houston Texans vs. Kansas City Chiefs matchup at GEHA Field at Arrowhead Stadium will take place on Saturday, December 21 at 1:00pm.

As the playoffs apporoach, track the top teams with Dimers' updated NFL futures, highlighting top Super Bowl contenders.

Pittsburgh Steelers vs. Baltimore Ravens

We are picking the Ravens to win their game against the Steelers this week, with our trusted NFL model projecting a 74% win probability for the home team. The Steelers have a 26% chance of winning at M&T Bank Stadium.

For betting purposes, the Ravens are listed as -6.5 favorites, with the Steelers' moneyline at +240.

The Pittsburgh Steelers vs. Baltimore Ravens game at M&T Bank Stadium is slated for Saturday, December 21 at 4:30pm.

Cleveland Browns vs. Cincinnati Bengals

According to our predictive analytics model, the Bengals are the team to beat in this game, with their win probability at 77%. The Browns, on the other hand, have a 23% chance of winning.

The Cleveland Browns vs. Cincinnati Bengals game at Paycor Stadium is set for Sunday, December 22 at 1:00pm.

New York Giants vs. Atlanta Falcons

The Falcons have an 81% chance of winning on Sunday afternoon, compared to the Giants' 19% chance of victory. This makes the Atlanta Falcons our pick to win at Mercedes-Benz Stadium.

The New York Giants vs. Atlanta Falcons matchup at Mercedes-Benz Stadium is scheduled for Sunday, December 22 at 1:00pm.

Detroit Lions vs. Chicago Bears

The Lions are favored to win their game this week, with our model giving them a 70% chance, while the Bears enter the weekend with a 30% chance of causing an upset at Soldier Field.

When it comes to betting on this game, the Lions' moneyline odds are set at -295, with the home team Bears listed as +6.5 underdogs.

The Detroit Lions vs. Chicago Bears game at Soldier Field will take place on Sunday, December 22 at 1:00pm.

Tennessee Titans vs. Indianapolis Colts

After 10,000 simulations of Titans vs. Colts this Sunday, our model projects the Colts as the more likely winners with a probability of 61%. Their opponents, the Titans, have a 39% chance of getting the win on the road.

The Tennessee Titans vs. Indianapolis Colts matchup at Lucas Oil Stadium is slated for Sunday, December 22 at 1:00pm.

Arizona Cardinals vs. Carolina Panthers

We are picking the Cardinals, who have a 67% chance of winning the game, while the Panthers have a 33% chance of an upset win.

The Arizona Cardinals vs. Carolina Panthers game at Bank of America Stadium will take place on Sunday, December 22 at 1:00pm.

Philadelphia Eagles vs. Washington Commanders

The next game of Week 16 sees the Eagles take on the Commanders at Northwest Stadium.

We predict the Eagles to win with a probability of 59%, while the Commanders are projected to have a win chance of 41%.

As for the Vegas betting odds here, the Commanders are listed as +3.5 underdogs, with the Eagles' moneyline odds posted at -180.

The Philadelphia Eagles vs. Washington Commanders game at Northwest Stadium is scheduled for Sunday, December 22 at 1:00pm.

Los Angeles Rams vs. New York Jets

The likely winner of this matchup is the Rams, who have a projected win chance of 61%, according to DimersBOT. On the other side of this matchup, the Jets have a projected win probability of 39%.

The Los Angeles Rams vs. New York Jets matchup at MetLife Stadium is set for Sunday, December 22 at 1:00pm.

Minnesota Vikings vs. Seattle Seahawks

We have run our powerful NFL model over this week’s Vikings-Seahawks clash 10,000 times, with the Vikings coming out as the team to pick. Of those 10,000 simulations, the Vikings won 6,240 times, with the Seahawks winning on 3,760 occasions.

The Minnesota Vikings vs. Seattle Seahawks game at Lumen Field is scheduled for Sunday, December 22 at 4:05pm.

New England Patriots vs. Buffalo Bills

Next up is the game between the Patriots and Bills, with our model projecting the home team as the more likely victor, with the Bills rated as having a 88% chance of getting the W. The Patriots, on the other hand, are projected to have a 12% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Patriots' moneyline odds set at +750 for this road game, while the hosting Bills are listed as -14 favorites.

The New England Patriots vs. Buffalo Bills game at Highmark Stadium will take place on Sunday, December 22 at 4:25pm.

Jacksonville Jaguars vs. Las Vegas Raiders

Our next straight up pick this week is for the Raiders to get the win against the Jaguars. After running 10,000 simulations of this matchup, the Las Vegas have a win probability of 56%, with the Jaguars at 44%.

The Jacksonville Jaguars vs. Las Vegas Raiders game at Allegiant Stadium is slated for Sunday, December 22 at 4:25pm.

San Francisco 49ers vs. Miami Dolphins

With a win probability of 51% on Sunday afternoon, our straight up pick for this matchup is the 49ers, while their opponent, the Dolphins, have a projected win chance of 49%.

The San Francisco 49ers vs. Miami Dolphins game at Hard Rock Stadium will take place on Sunday, December 22 at 4:25pm.

For a different angle on this week's NFL action, explore Dimers' NFL trends to spot the latest player prop trends.

Tampa Bay Buccaneers vs. Dallas Cowboys

The team to pick here is the Buccaneers, who have a 62% chance of winning their matchup against the Cowboys this Sunday night.

Looking at the betting odds for this Sunday Night Football clash, the Cowboys are listed as +4 underdogs at home, with the Buccaneers' moneyline odds available at -198.

The Tampa Bay Buccaneers vs. Dallas Cowboys game at AT&T Stadium is scheduled for Sunday, December 22 at 8:20pm.

New Orleans Saints vs. Green Bay Packers

Our pick to win the final game of Week 16 is the Packers, who have a win probability of 90%. Their opponents are projected to have a 10% chance of getting the W.

The New Orleans Saints vs. Green Bay Packers game at Lambeau Field is set for Monday, December 23 at 8:15pm.

Full List of NFL Week 16 Picks Straight Up:

• Chargers (59% win probability)
• Chiefs (63%)
• Ravens (74%)
• Bengals (77%)
• Falcons (81%)
• Lions (70%)
• Colts (61%)
• Cardinals (67%)
• Eagles (59%)
• Rams (61%)
• Vikings (62%)
• Bills (88%)
• Raiders (56%)
• 49ers (51%)
• Buccaneers (62%)
• Packers (90%)

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NFL Straight Up Picks and Predictions for Week 16

The NFL Week 16 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.

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