NFL Picks and Predictions Straight Up: Week 10, 2024

At Dimers.com, we provide NFL picks straight up for Week 10 and beyond, as part of our comprehensive NFL picks and NFL predictions coverage.

With Week 10 of the NFL season here, we've leveraged our powerful predictive analytics model to deliver a list of NFL straight up picks for all 14 games this week.

Secure an advantage in your NFL pick 'em contests by following our data-driven NFL Week 10 picks straight up, powered by thousands of game simulations.

Week 10 of the NFL season features 14 games, starting with the Cincinnati Bengals facing the Baltimore Ravens on Thursday night and ending with the Miami Dolphins taking on the Los Angeles Rams on Monday.

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For more NFL betting coverage, check out the best NFL week 10 odds for a breakdown on the moneyline, spread and total for every game this week.

NFL Picks This Week Straight Up: Week 10, 2024

Here are our Week 10 NFL picks, highlighting how likely each team is to win their game this week.

Cincinnati Bengals vs. Baltimore Ravens

The Bengals kick off Week 10 against the Ravens at M&T Bank Stadium on Thursday night. According to our predictive analytics model, the Ravens have a 70% chance of winning, while the Bengals have a 30% chance.

For Week 10's opening game, our model highlights NFL player props with Chase Brown (RB) as the most likely player from the Bengals to score the first TD at 9.2%, while Derrick Henry (RB) is the top candidate from the Ravens at 17.8%.

The Cincinnati Bengals vs. Baltimore Ravens game at M&T Bank Stadium is scheduled for Thursday, November 7 at 8:15pm. All times mentioned in this article are in Eastern Standard Time (EST).

New York Giants vs. Carolina Panthers

For this week's game between the Giants and the Panthers, NY Giants is more likely to win. Our prediction model gives the Giants a 72% chance of winning. On the other hand, there is a 28% chance that the Panthers will pull off an upset win.

The New York Giants vs. Carolina Panthers matchup at Allianz Arena will take place on Sunday, November 10 at 9:30am.

As the regular season approaches its conclusion, track the top teams with Dimers' updated NFL futures, highlighting top Super Bowl contenders.

San Francisco 49ers vs. Tampa Bay Buccaneers

We are picking the 49ers to win their game against the Buccaneers this week, with our famous NFL model projecting a 64% win probability for the road team. The Buccaneers have a 36% chance of winning at Raymond James Stadium.

For betting purposes, the Buccaneers are listed as +5.5 underdogs, with the 49ers' moneyline at -230.

The San Francisco 49ers vs. Tampa Bay Buccaneers game at Raymond James Stadium is slated for Sunday, November 10 at 1:00pm.

Atlanta Falcons vs. New Orleans Saints

According to our predictive analytics model, the Falcons are the team to beat in this game, with their win probability at 63%. The Saints, on the other hand, have a 37% chance of winning.

The Atlanta Falcons vs. New Orleans Saints game at Caesars Superdome is set for Sunday, November 10 at 1:00pm.

Denver Broncos vs. Kansas City Chiefs

The Chiefs have a 78% chance of winning on Sunday afternoon, compared to the Broncos' 22% chance of victory. This makes the Kansas City Chiefs our pick to win at GEHA Field at Arrowhead Stadium.

The Denver Broncos vs. Kansas City Chiefs matchup at GEHA Field at Arrowhead Stadium is scheduled for Sunday, November 10 at 1:00pm.

Buffalo Bills vs. Indianapolis Colts

The Bills are favored to win here, with our predictive analytics model giving them a 62% chance, while the Colts enter the weekend with a 38% chance of causing an upset at Lucas Oil Stadium.

When it comes to betting on this game, the Bills' moneyline odds are set at -198, with the home team Colts listed as +4.5 underdogs.

The Buffalo Bills vs. Indianapolis Colts game at Lucas Oil Stadium will take place on Sunday, November 10 at 1:00pm.

Pittsburgh Steelers vs. Washington Commanders

After 10,000 simulations of Steelers vs. Commanders this Sunday, our model projects the Commanders as the more likely winners with a probability of 63%. Their opponents, the Steelers, have a 37% chance of getting the win on the road.

The Pittsburgh Steelers vs. Washington Commanders matchup at Northwest Stadium is slated for Sunday, November 10 at 1:00pm.

Minnesota Vikings vs. Jacksonville Jaguars

DimersBOT is picking the Vikings, who have a 63% chance of winning the matchup, while the Jaguars have a 37% chance of an upset win.

The Minnesota Vikings vs. Jacksonville Jaguars game at EverBank Stadium will take place on Sunday, November 10 at 1:00pm.

New England Patriots vs. Chicago Bears

The next game of Week 10 sees the Patriots take on the Bears at Soldier Field.

We predict the Bears to win with a probability of 72%, while the Patriots are projected to have a win chance of 28%.

As for the Vegas betting odds here, the Bears are listed as -6.5 favorites, with the Patriots' moneyline odds posted at +230.

The New England Patriots vs. Chicago Bears game at Soldier Field is scheduled for Sunday, November 10 at 1:00pm.

Tennessee Titans vs. Los Angeles Chargers

The likely winner of this matchup is the Chargers, who have a projected win chance of 79%, according to DimersBOT. On the other side of this matchup, the Titans have a projected win probability of 21%.

The Tennessee Titans vs. Los Angeles Chargers matchup at SoFi Stadium is set for Sunday, November 10 at 4:05pm.

Philadelphia Eagles vs. Dallas Cowboys

We have run our powerful NFL model over this week’s Eagles-Cowboys clash 10,000 times, with the Eagles coming out as the team to pick. Of those 10,000 simulations, the Eagles won 7,454 times, with the Cowboys winning on 2,546 occasions.

The Philadelphia Eagles vs. Dallas Cowboys game at AT&T Stadium is scheduled for Sunday, November 10 at 4:25pm.

New York Jets vs. Arizona Cardinals

Next up is the game between the Jets and Cardinals, with our model projecting the home team as the more likely victor, with the Cardinals rated as having a 52% chance of getting the W. The Jets, on the other hand, are projected to have a 48% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Jets' moneyline odds set at -100 for this road game, while the hosting Cardinals are listed as -1 favorites.

The New York Jets vs. Arizona Cardinals game at State Farm Stadium will take place on Sunday, November 10 at 4:25pm.

Detroit Lions vs. Houston Texans

Our next straight up pick this week is for the Lions to get the win against the Texans. After running 10,000 simulations of this matchup, the Detroit have a win probability of 62%, with the Texans at 38%.

The Detroit Lions vs. Houston Texans game at NRG Stadium is slated for Sunday, November 10 at 8:20pm.

Miami Dolphins vs. Los Angeles Rams

With a win probability of 59% on Monday night, our straight up pick for this matchup is the Rams, while their opponent, the Dolphins, have a projected win chance of 41%.

The Miami Dolphins vs. Los Angeles Rams game at SoFi Stadium will take place on Monday, November 11 at 8:15pm.

For a different angle on this week's NFL action, explore our NFL trends to find the latest player prop trends.

Full List of NFL Week 10 Picks Straight Up:

• Ravens (70% win probability)
• Giants (72%)
• 49ers (64%)
• Falcons (63%)
• Chiefs (78%)
• Bills (62%)
• Commanders (63%)
• Vikings (63%)
• Bears (72%)
• Chargers (79%)
• Eagles (75%)
• Cardinals (52%)
• Lions (62%)
• Rams (59%)

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NFL Straight Up Picks and Predictions for Week 10

The NFL Week 10 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.

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