NFL Picks and Predictions Straight Up: Week 16, 2023

Dimers.com provides weekly NFL picks straight up as part of our NFL Picks coverage.

Week 16 of the NFL season is upon us, and we've used our sophisticated predictive analytics model to give you straight up NFL picks for all 16 games this week.

Secure an edge in NFL pick 'em contests with our data-driven NFL picks for Week 16 of the 2023 NFL season. These picks are based on over 10,000 simulations of each NFL game.

There are 16 games scheduled for Week 16 of the 2023 NFL season, beginning with the New Orleans Saints playing the Los Angeles Rams on Thursday night and concluding with the Baltimore Ravens facing the San Francisco 49ers on Monday night.

These straight up picks for Week 16 are sponsored by Bet365, which has an outstanding Bet $5, Get $150 in Bonus Bets promo for new customers.

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See below for a full list of each team's chances of winning in Week 16 of the NFL.

Straight Up NFL Picks - Week 16

Here are our Week 16 NFL predictions, which show how likely it is that each NFL team will win its game this week.

New Orleans Saints vs. Los Angeles Rams

The Saints take on the Rams at SoFi Stadium on Thursday to start Week 16. According to our NFL model, the Rams have a 65% chance of winning, while the Saints have a 35% chance.

When looking at player props for the opening game of Week 16, our model projects Chris Olave (WR) as the most likely player from the Saints to score the first TD in the game with a probability of 10.1%, while Kyren Williams (RB) is the most likely from the Rams at 14.8%.

New Orleans Saints vs. Los Angeles Rams is at SoFi Stadium on Thursday, December 21 at 8:15pm EST.

All times stated in this article are in Eastern Standard Time (EST).

Cincinnati Bengals vs. Pittsburgh Steelers

In this week's game between the Bengals and the Steelers, Cincinnati is more likely to win. Our prediction model gives the Bengals a 65% chance of winning. On the other hand, there is a 35% chance that the Steelers will win.

Cincinnati Bengals vs. Pittsburgh Steelers is at Acrisure Stadium on Saturday, December 23 at 4:30pm.

MORE: Super Bowl Odds

Buffalo Bills vs. Los Angeles Chargers

We are picking the Bills to win their game against the Chargers this week, with our trusted NFL model projecting an 82% win probability for the road team. The Chargers have a 18% chance of winning.

If you're looking to bet on this clash, Bet365 has the Chargers listed as +12 underdogs, whilst the Bills' moneyline odds are at -625.

Buffalo Bills vs. Los Angeles Chargers is at SoFi Stadium on Saturday, December 23 at 8:00pm.

Seattle Seahawks vs. Tennessee Titans

According to our predictive analytics model, the Seahawks are the team to beat in this game, with their win probability at 64%. The Titans, on the other hand, have a 36% chance of winning.

Seattle Seahawks vs. Tennessee Titans is at Nissan Stadium on Sunday, December 24 at 1:00pm.

MORE: NFL Best Bets

Indianapolis Colts vs. Atlanta Falcons

The Colts have a 61% chance of winning on Sunday afternoon, compared to the Falcons' 39% chance of victory. This makes the Indianapolis Colts our pick to win at Mercedes-Benz Stadium.

Indianapolis Colts vs. Atlanta Falcons is at Mercedes-Benz Stadium on Sunday, December 24 at 1:00pm.

Cleveland Browns vs. Houston Texans

The Texans are favored to win here, with our model giving them a 60% chance, while the Browns enter the weekend with a 40% chance of securing a win at NRG Stadium.

When it comes to betting on this game, Bet365 has the Browns' moneyline odds set at +120, with the home team Texans listed as -2.5 favorites.

Cleveland Browns vs. Houston Texans is at NRG Stadium on Sunday, December 24 at 1:00pm.

Green Bay Packers vs. Carolina Panthers

After 10,000 simulations of Packers vs. Panthers this Sunday, our model projects the Packers as the more likely winners with a probability of 73%. Their opponents the Panthers have a 27% chance of getting the win at home.

Green Bay Packers vs. Carolina Panthers is at Bank of America Stadium on Green Bay, December 24 at 1:00pm.

MORE: NFL Player Props

Washington Commanders vs. New York Jets

We are picking the Jets in this matchup, with the Jets given a 60% chance of winning, while the Commanders have a 40% win probability.

Washington Commanders vs. New York Jets is at MetLife Stadium on Sunday, December 24 at 1:00pm.

Detroit Lions vs. Minnesota Vikings

The next game of Week 16 sees the Lions take on the Vikings at U.S. Bank Stadium.

We are predicting the Lions to win with probability of 64%, while the Vikings are projected to have a win chance of 36%.

As for the Vegas betting odds here, Bet365 has the Vikings listed as +3 underdogs, with the Lions' moneyline odds posted at -160.

Detroit Lions vs. Minnesota Vikings is at U.S. Bank Stadium on Sunday, December 24 at 1:00pm.

Jacksonville Jaguars vs. Tampa Bay Buccaneers

The likely winner of this matchup is the Jaguars who have a projected win chance of 53% according to DimersBOT. On the other side of this matchup, the Buccaneers have a projected win probability of 47%.

Jacksonville Jaguars vs. Tampa Bay Buccaneers is at Raymond James Stadium on Sunday, December 24 at 4:05pm.

MORE: Best NFL Bets Today

Arizona Cardinals vs. Chicago Bears

We have run our powerful NFL model over this week’s Cardinals-Bears clash 10,000 times, with the Bears coming out as the team to pick. Of those 10,000 simulations, the Bears won 6,504 times, with the Cardinals winning on 3,496 occasions.

Arizona Cardinals vs. Chicago Bears is at Soldier Field on Sunday, December 24 at 4:25pm.

Dallas Cowboys vs. Miami Dolphins

Next up is the game between the Cowboys and Dolphins, with our model projecting the home team as the more likely victor, with Dolphins rated as a 56% chance of getting the W. The Cowboys on the other hand are projected to have a 44% chance of winning.

For those interested in betting on this matchup, Bet365 has the Cowboys' moneyline odds set at +102 for this road game, whilst the hosting Dolphins are listed as -1.5 favorites.

Dallas Cowboys vs. Miami Dolphins is at Hard Rock Stadium on Sunday, December 24 at 4:25pm.

New England Patriots vs. Denver Broncos

Our next straight up pick this week is for the Broncos to get the win against the Patriots. After running 10,000 simulations of this matchup, the Denver have a win probability of 83%, with the Patriots at 17%.

New England Patriots vs. Denver Broncos is at Empower Field at Mile High on Sunday, December 24 at 8:15pm.

Las Vegas Raiders vs. Kansas City Chiefs

With a win probability of 83% on Monday afternoon, our straight up pick for this game is the Chiefs, while their opponent, the Raiders, have a projected win chance of 17%.

Las Vegas Raiders vs. Kansas City Chiefs is at GEHA Field at Arrowhead Stadium on Monday, December 25 at 1:00pm.

MORE: NFL Player Prop Picks for Week 16

New York Giants vs. Philadelphia Eagles

The team to pick here is the Eagles who have a 87% chance of winning their matchup against the Giants this Sunday afternoon.

Looking at the betting odds for this Monday afternoon clash, Bet365 has the Eagles listed as -10.5 favorites at home, with the Giants' moneyline odds available at +440.

New York Giants vs. Philadelphia Eagles is at Lincoln Financial Field on Monday, December 25 at 4:30pm.

Baltimore Ravens vs. San Francisco 49ers

Our pick to win the final game of Week 16 is 49ers, who have a win probability of 71%. Their opponents are projected to have a 29% chance of getting the W.

Baltimore Ravens vs. San Francisco 49ers is at Levi's Stadium on Monday, December 25 at 8:15pm.

NFL Picks This Week Straight Up [Week 16, 2023]

• Rams (65% win probability)
• Bengals (65%)
• Bills (82%)
• Seahawks (64%)
• Colts (61%)
• Texans (60%)
• Packers (73%)
• Jets (60%)
• Lions (64%)
• Jaguars (53%)
• Bears (65%)
• Dolphins (56%)
• Broncos (83%)
• Chiefs (83%)
• Eagles (87%)
• 49ers (71%)

NFL Week 16 Slate and Game Times

• Saints vs. Rams (Thursday, 8:15PM ET)
• Bengals vs. Steelers (Saturday, 4:30PM ET)
• Bills vs. Chargers (Saturday, 8:00PM ET)
• Seahawks vs. Titans (Sunday, 1:00PM ET)
• Colts vs. Falcons (Sunday, 1:00PM ET)
• Browns vs. Texans (Sunday, 1:00PM ET)
• Packers vs. Panthers (Sunday, 1:00PM ET)
• Commanders vs. Jets (Sunday, 1:00PM ET)
• Lions vs. Vikings (Sunday, 1:00PM ET)
• Jaguars vs. Buccaneers (Sunday, 4:05PM ET)
• Cardinals vs. Bears (Sunday, 4:25PM ET)
• Cowboys vs. Dolphins (Sunday, 4:25PM ET)
• Patriots vs. Broncos (Sunday, 8:15PM ET)
• Raiders vs. Chiefs (Monday, 1:00PM ET)
• Giants vs. Eagles (Monday, 4:30PM ET)
• Ravens vs. 49ers (Monday, 8:15PM ET)

All times mentioned in this article are in Eastern Standard Time (EST).

NFL Week 16 Bye Teams: Who Has a Bye This Week?

All 32 teams are set to play in Week 16 of the 2023 NFL season, which means no team has a bye this week.

NFL Straight Up Picks and Predictions - Week 16

The NFL Week 16 picks straight up in this article are correct at the time of publication and are subject to change.

Dimers is the best site for NFL predictions, and our straight up picks are being used by football fans all over the country.

If you choose to use our NFL straight up picks for betting purposes, it's crucial that you gamble responsibly and manage your finances effectively. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Please note that all of the NFL odds and probabilities on this page are subject to change.

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