NFL Picks Against the Spread for Week 6, 2024

As part of our extensive NFL betting coverage, Dimers.com provides weekly NFL picks against the spread, and for Week 6, we've utilized our advanced predictive analytics model to deliver NFL spread picks for all 14 games.

With professional NFL picks against spread for every game on the Week 6 NFL slate, our expert predictive model is here to guide you through another massive week of football.

Below, you'll find a detailed breakdown of how likely each team is to cover the spread in Week 6 of the NFL, based on over 10K simulations of each game. These NFL predictions for Week 6 show the probability of each team covering the spread in their respective games.

While the picks in this article are based purely on probabilities, it's crucial for bettors to note that the best betting value may come from better odds available elsewhere.

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For more NFL betting coverage, check out the best NFL week 6 odds and our NFL Week 6 straight up picks.

NFL Spread Picks: Week 6, 2024

San Francisco 49ers vs. Seattle Seahawks (+3.5)

The opening game of Week 6 features the Seahawks hosting the 49ers, with Seattle listed as a 3.5-point underdog.

After 10,000 simulations of this matchup, our expertly tuned model projects the Seahawks as having a 59% chance of covering the spread, while the 49ers have a 41% chance.

• Pick ATS: Seahawks +3.5

Jacksonville Jaguars vs. Chicago Bears (-1.5)

Simulations show a 52% chance of the Bears (--1.5) covering the spread at Tottenham Hotspur Stadium, while the Jaguars have a 48% chance.

• Pick ATS: Bears -1.5

Tampa Bay Buccaneers vs. New Orleans Saints (+3.5)

The Saints are listed as +3.5 underdogs against the Buccaneers this week.

Our model projects the Saints as the more likely team to cover, with a probability of 59%, compared to 41% for the Buccaneers.

• Pick ATS: Saints +3.5

Arizona Cardinals vs. Green Bay Packers (-5)

Our simulations give the Packers and Cardinals each a 50% chance of covering the spread at Lambeau Field on Sunday. However, if you need to make a pick, the Packers get a slight edge.

• Pick ATS: Packers -5

For those interested in betting on the spread, the oddsmakers have listed the Cardinals at -108 to cover and the Packers at -110.

Indianapolis Colts vs. Tennessee Titans (-2.5)

At home against the Colts, the Titans are 2.5-point favorites.

Our model projects that the sportsbooks have nailed this one, with a 50-50 chance of either team covering the spread.

However, when searching for a pick, the Titans get a slight lean.

• Pick ATS: Titans -2.5

Cleveland Browns vs. Philadelphia Eagles (-9.5)

Our model projects a 53% chance of the Browns covering the spread against the Eagles, who have a 47% chance.

The line is set with Philadelphia as 9.5-point favorites at home.

• Pick ATS: Browns +9.5

Houston Texans vs. New England Patriots (+6.5)

In this game at Gillette Stadium, the Texans are 6.5-point favorites at road.

According to our model, the Texans have a 54% chance of covering the spread, while the Patriots have a 46% chance.

• Pick ATS: Texans -6.5

Washington Commanders vs. Baltimore Ravens (-6.5)

Our model predicts the Ravens to cover the spread in this game, giving them a slight edge in what is essentially a 50-50 projection against the Commanders.

• Pick ATS: Ravens -6.5

For those looking to place a bet, the line is set at Ravens -6.5, with the odds at -108 for the Ravens to cover at home and -108 for the Commanders to cover on the road.

Los Angeles Chargers vs. Denver Broncos (+2.5)

Our simulations suggest a 56% chance of LA Chargers covering the spread, while the Broncos have a 44% chance.

The traveling Chargers are slight favorites with a 2.5-point spread in Week 6 against the Broncos.

• Pick ATS: Chargers -2.5

Pittsburgh Steelers vs. Las Vegas Raiders (+3)

The Steelers enter this matchup as 3-point favorites on the road against the Raiders.

According to our simulations, both the Raiders and Steelers have a 50% chance of covering, with the Raiders slightly favored for those in against the spread pick contests.

• Pick ATS: Raiders -3

For those interested in betting on this line, the Steelers are listed at -105 to cover, with the Raiders also at -105.

Atlanta Falcons vs. Carolina Panthers (+6.5)

With a probability of 53%, our pick to cover in this game is the Panthers +6.5. The Falcons, their opponent, have a projected 47% chance of covering the spread.

• Pick ATS: Panthers +6.5

Detroit Lions vs. Dallas Cowboys (+3)

Both the Cowboys and Lions have a 50% chance of covering the spread on Sunday afternoon.

However, our pick is the Cowboys, who covered the spread in slightly more of the 10,000 simulations we ran for the game at Allegiant Stadium.

• Pick ATS: Cowboys +3

Cincinnati Bengals vs. New York Giants (+3.5)

We've run our powerful NFL model 10,000 times for this week’s Bengals-Giants clash, with our model unable to split the two teams at the line.

With the sportsbooks nailing the 3.5-point gap between the teams, our pick is the Giants to cover, who have a slightly higher probability.

• Pick ATS: Giants +3.5

Buffalo Bills vs. New York Jets (+2.5)

Our simulations indicate a 50-50 chance of both the Jets and Bills covering in this matchup.

However, the Jets emerged as the pick in slightly more simulations, making NY Jets our pick against the spread for the Week 6 game at MetLife Stadium.

• Pick ATS: Jets +2.5

NFL Week 6 Picks Against the Spread:

• Seahawks +3.5 (59%)
• Bears -1.5 (52%)
• Saints +3.5 (59%)
• Packers -5 (slight lean)
• Titans -2.5 (slight lean)
• Browns +9.5 (53%)
• Texans -6.5 (54%)
• Ravens -6.5 (slight lean)
• Chargers -2.5 (56%)
• Raiders -3 (slight lean)
• Panthers +6.5 (53%)
• Cowboys +6.5 (slight lean)
• Giants +3.5 (slight lean)
• Jets +2.5 (slight lean)

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NFL Week 6 Slate and Game Times

Below is the schedule and start times for each Week 6 matchup, so you can catch every moment of the action.

• 49ers vs. Seahawks (Thursday, 8:15PM ET)
• Jaguars vs. Bears (Sunday, 9:30AM ET)
• Buccaneers vs. Saints (Sunday, 1:00PM ET)
• Cardinals vs. Packers (Sunday, 1:00PM ET)
• Colts vs. Titans (Sunday, 1:00PM ET)
• Browns vs. Eagles (Sunday, 1:00PM ET)
• Texans vs. Patriots (Sunday, 1:00PM ET)
• Commanders vs. Ravens (Sunday, 1:00PM ET)
• Chargers vs. Broncos (Sunday, 4:05PM ET)
• Steelers vs. Raiders (Sunday, 4:05PM ET)
• Falcons vs. Panthers (Sunday, 4:25PM ET)
• Lions vs. Cowboys (Sunday, 4:25PM ET)
• Bengals vs. Giants (Sunday, 8:20PM ET)
• Bills vs. Jets (Monday, 8:15PM ET)

Week 6 NFL Picks Against Spread

The NFL Week 6 picks against the spread in this article are accurate at the time of publication and may be subject to change.

Football fans across the country rely on our NFL expert picks against the spread because Dimers.com is the best website for NFL predictions.

If you decide to use our NFL spread picks for betting, it's important that you gamble responsibly and manage your finances effectively. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Please note that all NFL odds and probabilities on this page are subject to change.

Conclusion

Our Week 6 NFL picks against the spread start with the Seahawks +3.5 at a 59% probability on Thursday Night Football, with the week concluding as we pick the Jets +2.5 with a slight lean.

For more Week 6 betting tools, explore our NFL odds, NFL prop bets, NFL trends and NFL futures.