NFL Picks Against the Spread for Wild Card Weekend, 2025

As part of our comprehensive NFL betting coverage, Dimers.com offers a weekly list of NFL picks against the spread, and for Wild Card Weekend, we've harnessed our advanced predictive analytics model to deliver NFL spread picks for all six games.

With professional NFL picks against spread for each game on the this week's NFL slate, our expert predictive model is here to guide you through another massive week of football.

Below, you'll find a detailed list of each team's chances of covering the spread on Wild Card Weekend, based on thousands of simulations of each game. These NFL predictions for Wild Card Weekend show the probability of each team covering the spread in their respective games.

While the picks in this article are based purely on probabilities, it's crucial for bettors to note that the best betting value may come from better odds available elsewhere.

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For more NFL betting coverage, check out the best NFL Wild Card Weekend odds and our NFL Wild Card Weekend straight up picks.

NFL Spread Picks: Wild Card Weekend, 2025

Los Angeles Chargers vs. Houston Texans (+2.5)

The opening game of Wild Card Weekend features the Texans hosting the Chargers, with Houston listed as a 2.5-point underdog.

After 10,000 simulations of this matchup, our expertly tuned model projects the Chargers as having a 56% chance of covering the spread, while the Texans have a 44% chance.

• Pick ATS: Chargers -2.5

Pittsburgh Steelers vs. Baltimore Ravens (-9.5)

Simulations show a 53% chance of the Steelers (+-9.5) covering the spread at M&T Bank Stadium, while the Ravens have a 47% chance.

• Pick ATS: Steelers +9.5

Denver Broncos vs. Buffalo Bills (-8.5)

The Bills are listed as -8.5 favorites against the Broncos this week.

Our model projects the Broncos as the more likely team to cover, with a probability of 57%, compared to 43% for the Bills.

• Pick ATS: Broncos +8.5

Green Bay Packers vs. Philadelphia Eagles (-5)

Our simulations give the Packers a 56% chance of covering the -5 spread on the road against the Eagles, who have a 44% chance.

• Pick ATS: Packers +5

For those interested in betting on the spread, the oddsmakers have listed the Packers and Eagles each at -110 to cover.

Washington Commanders vs. Tampa Bay Buccaneers (-3)

At home against the Commanders, the Buccaneers are 3-point favorites.

Our model projects that the sportsbooks have nailed this one, with a 50-50 chance of either team covering the spread.

However, when searching for a pick, the Buccaneers get a slight lean.

• Pick ATS: Buccaneers -3

Minnesota Vikings vs. Los Angeles Rams (+2.5)

Our model projects an even 50-50 chance for both the Rams and Vikings to cover in this matchup, with the Rams slightly favored.

The line is set with Minnesota as 2.5-point favorites on the road.

• Pick ATS: Rams +2.5

Complete List of NFL Wild Card Weekend Picks Against the Spread:

• Chargers -2.5 (56%)
• Steelers +9.5 (53%)
• Broncos +8.5 (57%)
• Packers +5 (56%)
• Buccaneers -3 (slight lean)
• Rams +2.5 (slight lean)

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NFL Wild Card Weekend Slate and Game Times

Below is the schedule and start times for each Wild Card Weekend matchup, so you can catch every moment of the action.

• Chargers vs. Texans (Saturday, 4:30PM ET)
• Steelers vs. Ravens (Saturday, 8:00PM ET)
• Broncos vs. Bills (Sunday, 1:00PM ET)
• Packers vs. Eagles (Sunday, 4:30PM ET)
• Commanders vs. Buccaneers (Sunday, 8:00PM ET)
• Vikings vs. Rams (Monday, 8:00PM ET)

Wild Card Weekend NFL Picks Against Spread

The NFL Wild Card Weekend picks against the spread in this article are accurate at the time of publication and may be subject to change.

Football fans across the country rely on our NFL expert picks against the spread because Dimers.com is the best website for NFL predictions.

If you choose to use our NFL spread picks for betting, it's important that you gamble responsibly and keep track of your money. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Please note that all NFL odds and probabilities on this page are subject to change.

Conclusion

Our NFL Wild Card Weekend picks against the spread start with the Chargers -2.5 at a 56% probability on Saturday, with the week concluding as we pick the Rams +2.5 with a slight lean.

For more Wild Card Weekend betting tools, explore our NFL odds, NFL prop bets, NFL trends and NFL futures.