NFL Picks Against the Spread for Week 18, 2025

As part of our extensive NFL betting coverage, Dimers.com provides a weekly list of NFL picks against the spread, and for Week 18, we've harnessed our sophisticated predictive analytics model to deliver NFL spread picks for all 16 games.

With professional NFL picks against spread for every game on the Week 18 NFL slate, our expert predictive model is here to guide you through another massive week of football.

Below, you'll find a detailed breakdown of each team's chances of covering the spread in Week 18 of the NFL, based on over 10K simulations of each game. These NFL predictions for Week 18 show the probability of each team covering the spread in their respective games.

While the picks in this article are based purely on probabilities, it's crucial for bettors to note that the best betting value may come from better odds available elsewhere.

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For more NFL betting coverage, check out the best NFL week 18 odds and our NFL Week 18 straight up picks.

NFL Spread Picks: Week 18, 2025

Cleveland Browns vs. Baltimore Ravens (-19.5)

The opening game of Week 18 features the Ravens hosting the Browns, with Baltimore listed as a 19.5-point favorite.

After 10,000 simulations of this matchup, our expertly tuned model projects the Browns as having a 51% chance of covering the spread, while the Ravens have a 49% chance.

• Pick ATS: Browns +19.5

Cincinnati Bengals vs. Pittsburgh Steelers (+1.5)

Simulations show a 52% chance of the Bengals (-1.5) covering the spread at Acrisure Stadium, while the Steelers have a 48% chance.

• Pick ATS: Bengals -1.5

New York Giants vs. Philadelphia Eagles (-3)

The Eagles are listed as -3 favorites against the Giants this week.

Our model projects both the Eagles and Giants to have a 50% chance of covering, with the Eagles slightly more likely when looking deep into the numbers.

• Pick ATS: Eagles -3

Chicago Bears vs. Green Bay Packers (-10.5)

Our simulations give the Bears a 56% chance of covering the -10.5 spread on the road against the Packers, who have a 44% chance.

• Pick ATS: Bears +10.5

For those interested in betting on the spread, the oddsmakers have listed the Bears at -115 to cover and the Packers at -105.

Carolina Panthers vs. Atlanta Falcons (-8.5)

At home against the Panthers, the Falcons are 8.5-point favorites.

Our model projects a 57% chance of the Panthers covering the spread, while the Falcons have a 43% chance.

• Pick ATS: Panthers +8.5

New Orleans Saints vs. Tampa Bay Buccaneers (-14)

Our model projects a 53% chance of the Saints covering the spread against the Buccaneers, who have a 47% chance.

The line is set with Tampa Bay as 14-point favorites at home.

• Pick ATS: Saints +14

Washington Commanders vs. Dallas Cowboys (+6.5)

In this game at AT&T Stadium, the Commanders are 6.5-point favorites at road.

According to our model, the Cowboys have a 53% chance of covering the spread, while the Commanders have a 47% chance.

• Pick ATS: Cowboys +6.5

Jacksonville Jaguars vs. Indianapolis Colts (-4.5)

Our model predicts the Colts to cover the spread in this game, giving them a 51% chance against the Jaguars.

• Pick ATS: Colts -4.5

For those looking to place a bet, the line is set at Colts -4.5, with the odds at -114 for the Colts to cover at home and -106 for the Jaguars to cover on the road.

Houston Texans vs. Tennessee Titans (-1.5)

Our simulations suggest a 50% chance for either of the Titans or Texans covering the spread.

Our model's slight lean goes to the Titans.

• Pick ATS: Titans -1.5

Buffalo Bills vs. New England Patriots (+2)

The Bills enter this matchup as 2-point favorites on the road against the Patriots.

According to our simulations, the Bills have a 56% chance of covering the spread, while the Patriots have a 44% chance.

• Pick ATS: Bills -2

For those interested in betting on this line, the Bills are listed at -125 to cover, with the Patriots at -105.

Kansas City Chiefs vs. Denver Broncos (-11)

With a probability of 56%, our pick to cover in this game is the Chiefs +11. The Broncos, their opponent, have a projected 44% chance of covering the spread.

• Pick ATS: Chiefs +11

San Francisco 49ers vs. Arizona Cardinals (-4.5)

The 49ers have a 52% chance of covering the spread on Sunday afternoon, compared to the Cardinals' 48% chance.

This makes the 49ers +4.5 our pick against the spread at Gillette Stadium.

• Pick ATS: 49ers +4.5

Miami Dolphins vs. New York Jets (+1)

We've run our powerful NFL model 10,000 times for this week’s Dolphins-Jets clash, with our model unable to split the two teams at the line.

With the sportsbooks nailing the 1-point gap between the teams, our pick is the Jets to cover, who have a slightly higher probability.

• Pick ATS: Jets +1

Seattle Seahawks vs. Los Angeles Rams (+6.5)

Our simulations indicate a 57% chance of the Rams covering the spread in this matchup, while the Seahawks have a 43% chance.

This makes the Rams a strong pick against the spread for the Week 18 game at SoFi Stadium.

• Pick ATS: Rams +6.5

Los Angeles Chargers vs. Las Vegas Raiders (+4.5)

We are picking the Raiders to cover the spread in their game against the Chargers this week.

According to our trusted NFL model, both teams are projected to have a 50% chance of covering, with the Raiders slightly more likely to do so on Sunday.

• Pick ATS: Raiders +4.5

Minnesota Vikings vs. Detroit Lions (-2.5)

The final game of Week 18 features the Vikings taking on the Lions at Ford Field.

We are picking the Lions to cover the spread, as this outcome occurred slightly more often in our 10,000 game simulations.

• Pick ATS: Lions -2.5

Complete List of NFL Week 18 Picks Against the Spread:

• Browns +19.5 (51%)
• Bengals -1.5 (52%)
• Eagles -3 (slight lean)
• Bears +10.5 (56%)
• Panthers +8.5 (57%)
• Saints +14 (53%)
• Cowboys +6.5 (53%)
• Colts -4.5 (51%)
• Titans -1.5 (slight lean)
• Bills -2 (56%)
• Chiefs +11 (56%)
• 49ers +4.5 (52%)
• Jets +1 (slight lean)
• Rams +6.5 (57%)
• Raiders +4.5 (slight lean)
• Lions -2.5 (slight lean)

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NFL Week 18 Slate and Game Times

Below is the schedule and start times for each Week 18 matchup, so you can catch every moment of the action.

• Browns vs. Ravens (Saturday, 4:30PM ET)
• Bengals vs. Steelers (Saturday, 8:00PM ET)
• Giants vs. Eagles (Sunday, 1:00PM ET)
• Bears vs. Packers (Sunday, 1:00PM ET)
• Panthers vs. Falcons (Sunday, 1:00PM ET)
• Saints vs. Buccaneers (Sunday, 1:00PM ET)
• Commanders vs. Cowboys (Sunday, 1:00PM ET)
• Jaguars vs. Colts (Sunday, 1:00PM ET)
• Texans vs. Titans (Sunday, 1:00PM ET)
• Bills vs. Patriots (Sunday, 1:00PM ET)
• Chiefs vs. Broncos (Sunday, 4:25PM ET)
• 49ers vs. Cardinals (Sunday, 4:25PM ET)
• Dolphins vs. Jets (Sunday, 4:25PM ET)
• Seahawks vs. Rams (Sunday, 4:25PM ET)
• Chargers vs. Raiders (Sunday, 4:25PM ET)
• Vikings vs. Lions (Sunday, 8:20PM ET)

Week 18 NFL Picks Against Spread

The NFL Week 18 picks against the spread in this article are accurate at the time of publication and may be subject to change.

Football fans across the country rely on our NFL expert picks against the spread because Dimers.com is the best website for NFL predictions.

If you decide to use our NFL spread picks for betting, it's important that you gamble responsibly and keep track of your money. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Please note that all NFL odds and probabilities on this page are subject to change.

Conclusion

Our Week 18 NFL picks against the spread start with the Browns +19.5 at a 51% probability on Saturday, with the week concluding as we pick the Lions -2.5 with a slight lean.

For more Week 18 betting tools, explore our NFL odds, NFL prop bets, NFL trends and NFL futures.