NFL Best Bets Today: Favorite Picks for the Week 6 Late Games on Sunday, October 16, 2022

Our NFL best bets are winning at a 78.3% clip this season, so check out what we have for the late afternoon Week 6 slate. This column will be specifically focusing on the games that start after 4:00PM ET, so buckle up and let's get some winners in before the Sunday Night Football game between the Dallas Cowboys vs. Philadelphia Eagles! 

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NFL Best Bets Today: Favorite Picks for the Week 6 Late Games on Sunday, October 16, 2022

Arizona Cardinals vs. Seattle Seahawks - 4:05PM ET

The Over has hit in each of the last three games that the Seahawks have played, with Seattle averaging 34.3 points per game in that span. This team isn't just playing high-scoring games because of its lousy defense, but the Seahawks now have one of the more explosive offenses in football. Geno Smith has been electric since filling in for Russell Wilson this year, throwing for 1,305 yards with nine touchdowns and only two interceptions. We don't see that slowing down too much in the near future, as he has a great group of weapons and an offensive system that suits his strengths well. 

On the other side of the ball, the Cardinals have a lot of firepower themselves. Their style of play doesn't always allow Kyler Murray to show off his full skill set, but you'd think that Arizona will find some success scoring on a Seattle defense that is giving up 30.8 points per game this year. Only the Detroit Lions are giving up more than the Seahawks do on a weekly basis, which is why we foresee this one turning into a shootout. 

The Over is actually 7-1 when Arizona is coming off a loss by six or less under Kliff Kingsbury, so we see him finding a way to get his offense going here. 

PICK: Over 50.5 (-106 at FanDuel Sportsbook)

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Buffalo Bills vs. Kansas City Chiefs - 4:25PM ET

This is a game in which everybody on the planet will be expecting a shootout, as these teams looked like Oklahoma State and Oklahoma in last year's postseason matchup. They combined to score 78 points in that 42-36 win for the Chiefs, and people will be expecting fireworks here. But the oddsmakers clearly aren't overthinking that one game, as they have this total set at less than last year's number. And overall, it looks like they're trying to trap bettors. 

While both of these teams are extremely explosive on the offensive side of the ball, Buffalo has the top defense in the entire league. That has to be considered here, especially with Kansas City no longer having the gamebreaking speed of Tyreek Hill to utilize. In that game last year, Hill had 11 catches for 150 yards and a touchdown. And his legs opened up all sorts of other opportunities for his teammates. And even the Bills could be slowed down a bit with this being an electric road atmosphere. 

In sports betting, the reality is that if something seems easy, it's probably the wrong way to go. That's why we're rolling with the Under. 

PICK: Under 53.5 (-105 at FanDuel Sportsbook)

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